Confirmation of paranitrophenol as a human urinary metabolite at the nanogram level

Kirby, Kenneth W.; Keiser, Jeffrey E.; Groene, J. B.; Slach, Edwin F.

doi:10.1021/jf60224a004

Cited by 16 publications

(4 citation statements)

References 5 publications

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“…All the methods presented in Table 6-l are for determining 4-nitrophenol in plasma or urine. Since 4-nitrophenol is a well known urinary metabolite in parathion-exposed subjects (Kirby et al 1979), it is not surprising that the methods attempt to quantify 4-nitrophenol. However, there is no reason to believe that the methods applicable to 4-nitrophenol will not be applicable to 2-nitrophenol.…”

Section: Biological Materialsmentioning

confidence: 99%

“…Among the commonly used methods, GC with electron capture detection of fluorinated derivates using heptafluorobutyric anhydride is probably the most sensitive method (Kirby et al 1979). Other less commonly used methods, such as the Hall electroconductivity detector (HECD), dropping-mercury electrode, pulse polarography, and an enzymatic procedure are given by Fatiadi (1984) and Kirby et al (1979). 4-Nitrophenol is excreted in urine entirely as glucuronide and sulfate conjugates (Fatiadi 1984).…”

Section: Biological Materialsmentioning

confidence: 99%

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Glauconite as a sorbent of 4-nitrophenol

Makhova¹,

Doronin²

2021

CBE

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The sorption properties of glauconite from Beloozersk deposits (Saratov region) for 4-nitrophenol (4-NF) have been investigated. The effect of glauconite on pH and 4-nitrophenol structure in solution is estimated. It is shown that glauconite increases pH of aqueous environment to 8 and shifts the equilibrium towards the formation of aci-form 4-NF. The conditions of sorption 4-NF by glauconite are established: the sorption time 20 min, the mass of the sorbent (0.50–1.0) g. The isotherm of sorption by 4-NF glauconite has been obtained; its interpretation is given using the Langmuir and Freundlich equations. The main quantitative sorption characteristics of glauconite such as recovery (R = 64%), distribution coefficient (D = 88) and the Langmuir and Freundlich constants for 4-nitrophenol are calculated. These experiments indicate the potential use of the glauconite from Beloozersk deposits (Saratov region) for 4-NP from various waters.

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Section: Biological Materialsmentioning

confidence: 99%

Section: Biological Materialsmentioning

confidence: 99%

Glauconite as a sorbent of 4-nitrophenol

Makhova¹,

Doronin²

2021

CBE

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“…Das Vorliegen von p-Nitrophenol in Kontrollproben ist jedoch nicht grunds~itzlich auszuschliegen [14].…”

Section: Grundlagenunclassified

“…sowie der Nachweis des Metaboliten p -N i t r o p h e n o l im Urin (nach Hydrolyse von Konjugaten) [4][5][6][7][8][9][10][11][12][13][14] zugrunde liegen.…”

unclassified

Empfindlicher Nachweis von p-Nitrophenol in Blut und Urin mit HPLC nach E 605-Intoxikation

Michalke

1982

Z Rechtsmed

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p-Nitrophenol, the main metabolite of parathion metabolism can be quantified by high performance liquid chromatography (HPLC) following very simple preparation of small quantities of blood the urine. Determination is carried out by UV detection at 315 nm following separation on a RP 18 column. Detection limits are 5-10 ng/ml serum and 50-100 ng/ml urine. levels of p-nitrophenol in blood and urine after survival from parathion intoxication are demonstrated.

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Parathion [BAT Value Documentation in German language, 1986]

Lewalter¹

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Biologische Arbeitsstoff‐Toleranz‐Werte (BAT‐Werte) und Expositionsäquivalente für krebserzeugende Arbeitsstoffe (EKA) , 3. Lieferung, Ausgabe 1986 Der Artikel enthält folgende Kapitel: Metabolismus und Kinetik Kritische Toxizität Belastung und Beanspruchung Auswahl der Indikatoren Untersuchungsmethoden Evaluierung des BAT‐Wertes Interpretation von Untersuchungsdaten

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Confirmation of paranitrophenol as a human urinary metabolite at the nanogram level

Cited by 16 publications

References 5 publications

Glauconite as a sorbent of 4-nitrophenol

Glauconite as a sorbent of 4-nitrophenol

Empfindlicher Nachweis von p-Nitrophenol in Blut und Urin mit HPLC nach E 605-Intoxikation

Parathion [BAT Value Documentation in German language, 1986]

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