Confirmation of early non-bulbar onset of amyotrophic lateral sclerosis in Spanish league soccer players.

Gamez, Josep; Carmona, Francesc

doi:10.1016/j.jns.2021.117586

Cited by 6 publications

(12 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1. A total of 17 articles were included in the qualitative summary [43,44,[72][73][74][75][76][77][78][79][80][81][82][83][84][85][86].…”

Section: Resultsmentioning

confidence: 99%

“…Overall, five cohort studies reported data on the frequency of all NDs/NCDs included in this review in former professional or varsity athletes [74,77,79,82,84]. Considering each single pathology, 10 cohort studies [82,84] and 1 case-control study [44] reported data on the frequency of dementia/MCI in former athletes, 8 cohort studies [43, 73-75, 77, 79, 82, 84], and 1 case-control study [44] reported data on the frequency of PD or Parkinsonism, 1 cohort study [80] reported data on CTE, and 7 new cohort studies [77,[82][83][84][85][86] and 1 new case-control study [81] reported data on the frequency of ALS or MND. The summary of the main characteristics, quality assessment and results from the included studies were reported according to each considered outcome in Tables 1, 2, 3, 4, and 5.…”

Section: Resultsmentioning

confidence: 99%

“…Most of the cohort studies used structured information from death certificates, clinical records, registries, or recordlinkage. Of the five remaining studies, 2 studies obtained data on the outcome by clinicians [72,78] 2 from questionnaires [73,77] and 2 only from databases or search engines (i.e., PubMed, Google) or books and magazines [83,85]. Using secure sources such as hospital records and certificates or using an independent validation of the diagnosis to confirm the outcome can minimize the potential for inaccurate information.…”

Section: Exposure/outcomementioning

confidence: 99%

“…The previous review [23] on the risk of ALS and MND in former professional and varsity athletes reported a significantly higher frequency of ALS and MND in professional soccer and American football players, and a slightly increased risk of ALS in varsity athletes. The update of the SR allowed to identify 6 new cohort studies [77,79,[82][83][84][85] and 1 new case-control study [81]. When considering professional athletes, 5 large cohort studies reported a significantly higher risk of ALS and MND in former soccer and American football players (MND: HR 3.52, p < 0.001; HR 4.33, p < 0.001; ALS: SIR 1.91; ALS: SIR 2.11; ALS: SIR 3.59) [82][83][84][85][86] compared to either general population [79][80][81][82] or matched controls [78].…”

Section: Als or Mndmentioning

confidence: 99%

“…The update of the SR allowed to identify 6 new cohort studies [77,79,[82][83][84][85] and 1 new case-control study [81]. When considering professional athletes, 5 large cohort studies reported a significantly higher risk of ALS and MND in former soccer and American football players (MND: HR 3.52, p < 0.001; HR 4.33, p < 0.001; ALS: SIR 1.91; ALS: SIR 2.11; ALS: SIR 3.59) [82][83][84][85][86] compared to either general population [79][80][81][82] or matched controls [78]. Two studies specifically reported a significantly higher risk in subjects aged < 45 (SIR: 4.66, 95% CI 2.66-7.57) years and in athletes playing in the top league (SIR 5.69, 95%CI 2.73-10.47) [83] and in athletes having longer careers (OR 1.2, 95% CI 1.1-1.3) [86].…”

Section: Als or Mndmentioning

confidence: 99%

See 4 more Smart Citations

A systematic review on the risk of neurodegenerative diseases and neurocognitive disorders in professional and varsity athletes

Bellomo

Corbo²,

Pupillo

et al. 2022

Neurol Sci

View full text Add to dashboard Cite

Objective The aim of this systematic review (SR) was to gather all available epidemiological evidence on former participation in any type of sport, at a professional and varsity level, as a potential risk factor for neurodegenerative diseases (NDs) and neurocognitive disorders (NCDs). Design Systematic searches were performed on PubMed, the Cochrane databases, and the ISI Web of Knowledge databases. Included studies were assessed using the NOS checklist. Eligibility criteria for selecting studies All epidemiological studies reporting data on the possible association between a clinical diagnosis of amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND), dementia or mild cognitive impairment (MCI), Parkinson’s disease (PD), chronic traumatic encephalopathy (CTE) at any stage and with any clinical pattern and the former participation in any types of sport at a varsity and professional level were included. Results Data from the 17 included studies showed a higher frequency of NDs and NCDs in former soccer and American football players. Updating the previous SR confirmed a higher frequency of ALS/MND in former soccer players. Data reported a significantly higher risk of dementia/AD in former soccer players, and of MCI in former American football players. Results also showed a significantly higher risk of PD in former soccer and American football players, and a significantly higher risk of CTE in former boxers and American football players. Summary/conclusions This SR confirmed a higher risk of NDs and NCDs in former professional/varsity athletes. However, the pathological mechanisms underlying this association remain unclear, and further high-quality studies should be performed to clarify whether the association could be sport specific.

show abstract