Confirmation of clorsulon residues in cattle kidney by capillary gas chromatography—negative-ion chemical-ionization mass spectrometry

Wehner, Teresa A.; Wood, James S.; Walker, Robert; Downing, George V.; Vandenheuvel, W.J.A.

doi:10.1016/s0021-9673(00)96127-2

Cited by 2 publications

(2 citation statements)

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“…The following solvents were used to prepare stock solutions of interfering agents (1.0 mmol L À 1 ): triple distilled water (sulfamethazine), ethanol (monensin, flumequine), and 10 mmol L À 1 HCl (enrofloxacin, ofloxacin, and ciprofloxacin). Potassium ferrocyanide (K 4 Britton-Robinson (B-R) buffer solutions were prepared by mixing buffer matrix (0.04 mol L À 1 mixture of H 3 BO 3 , H 3 PO 4 , and CH 3 COOH) with an appropriate volume of 0.20 mol L À 1 NaOH to gain the required pH values. Phosphate buffer (PB) solutions were composed of 0.20 mol L À 1 NaH 2 PO 4 adjusted to the required pH values using 0.20 mol L À 1 Na 2 HPO 4 × 7H 2 O.…”

Section: Materials Reagents and Standard Solutionsmentioning

confidence: 99%

“…So far, only a few analytical methods have been developed for the quantitative determination of Clo, mainly using chromatographic techniques, such as reversed phase high-performance liquid chromatography with UV detection (RPÀ HPLCÀ UV) [2], high-performance liquid chromatography with UV detection (HPLCÀ UV) [1], ultra-high-performance liquid chromatography with tandem mass spectrometry (UHPLCÀ MS/ MS) [3], gas chromatography-negative-ion chemical-ionization mass spectrometry (GCÀ NICIÀ MS) [4], liquid chromatography with matrix solid phase dispersion (MSPDÀ LC) [5], and liquid chromatography with reversed phase solid phase extraction (RPÀ SPEÀ LC) [6] in the following samples: beef [1], milk [1,3,5,6], egg [3], honey [3], muscle [3], cattle kidney [4], and commercial formulation [2]. However, electrochemical techniques can be successfully applied as a reliable tool in the quantitative analysis of pesticides [7][8][9], antibiotics [7,[10][11][12], drugs [13][14][15], and other substances requiring constant controlling [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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A Sensitive Sensor Based on Single‐walled Carbon Nanotubes: Its Preparation, Characterization and Application in the Electrochemical Determination of Drug Clorsulon in Milk Samples

et al. 2019

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Within this paper, a glassy carbon electrode modified with single‐walled carbon nanotubes (SWCNTs−GCE) was prepared, and employed for the determination of clorsulon (Clo), which is a frequently used veterinary drug against common liver fluke. The comprehensive topographical and electrochemical characterizations of bare GCE and SWCNTs−GCE were performed by atomic force microscopy, electrochemical impedance spectroscopy, and cyclic voltammetry. Significantly enhanced electrochemical characteristics of SWCNTs−GCE toward a ferrocyanide/ferricyanide redox couple was observed when compared to bare GCE. Further, the prepared sensor was applied for the voltammetric determination of Clo, which was electrochemically investigated for the first time in this work. Voltammetric experiments were performed using square‐wave voltammetry with optimized parameters in phosphate buffer solution, pH 6.8, which was selected as the most suitable medium for the determination of Clo. The corresponding current at approx. +1.1 V increased linearly with Clo concentration within two linear dynamic ranges of 0.75–4.00 μmol L−1 (R2=0.9934) and 4.00–15.00 μmol L−1 (R2=0.9942) with a sensitivity for the first calibration range of 0.76 μA L μmol−1, a limit of detection of 0.19 μmol L−1, and a limit of quantification of 0.64 μmol L−1. The developed method was subsequently applied for quantitative analysis of Clo in milk samples with results proving high repeatability and recovery.

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Section: Materials Reagents and Standard Solutionsmentioning

confidence: 99%