Confirmation of an old adage: You find what you seek

Sherman, Philip M.; Tarr, Phillip I.

doi:10.1016/j.jpeds.2004.10.056

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…; Clostridium difficile following antibiotic administration in non-infants; Giardia lamblia ; Entamoeba histolytica , Cryptosporidium parvum , Microsporidia , Cyclospora , Isospora ; rotavirus caliciviruses, astroviruses and adenoviruses. Diverse factors underlie our ignorance about the causes of specific cases of diarrhea (Sherman and Tarr, 2005) including expense (thorough evaluations cost hundreds of dollars) and futility (diagnosis rarely leads to treatment or when pathogens are detected late in illness the offending agent is often already cleared or the patient is already improved). Importantly the currently available methods for the detection of many of these pathogens lack sensitivity and in some cases specificity.…”

Section: The Undetermined Cause Of Many Cases Of Enteric Infectionsmentioning

confidence: 99%

Explaining unexplained diarrhea and associating risks and infections

Denno

Klein

Young

et al. 2007

Anim. Health. Res. Rev.

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Gastrointestinal illnesses are common afflictions. However, knowledge of their etiology is often lacking. Moreover, most cases of infections with reportable enteric pathogens (Campylobacter jejuni, Escherichia coli O157:H7, Salmonella, Shigella, Yersinia, Cryptosporidia and Giardia) have sporadic modes of acquisition, yet control measures are often biased towards mitigation of risks discerned by outbreak analysis. To determine the etiology of unexplained diarrhea it is important to study populations that can be matched to appropriate controls and to couple thorough classic microbiologic evaluation on receipt of specimens with archiving and outgrowth capabilities. Research evaluations should address the potential roles of a broad panel of candidate bacterial pathogens including diarrheagenic E. coli, Listeria monocytogenes, Helicobacters and jejuni Campylobacters, and also apply novel massively parallel sequencing and nucleic acid detection technologies that allow the detection of viral pathogens. To fill voids in our knowledge regarding sources of known enteric pathogens it will be critical to extend case-control studies to assess risk factors and exposures to patients with non-epidemic illnesses and to appropriate controls. By filling these gaps in our knowledge it should be possible to formulate rational prevention mechanisms for human gastrointestinal illnesses.

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Section: The Undetermined Cause Of Many Cases Of Enteric Infectionsmentioning

confidence: 99%