Confirmation of a proarrhythmic risk underlying the clinical use of common Chinese herbal intravenous injections

Safety profile of traditional Chinese herbal injection: An analysis of a spontaneous reporting system in China

“…Anaphylactic shock and anaphylactoid reaction are dangerous ADRs of high risk for both TCM injections and conventional injections. The results are consistent with literature …”

“…Adverse drug reactions (ADRs) are one of the main causes of death and a critical public health problem worldwide . In the past decades, a number of serious adverse events have continually raised concerns about the safety and potential toxicity of TCM injections . Most TCM products based the safety and efficacy on the long‐time clinical use in the history.…”

“…12,13 In the past decades, a number of serious adverse events have continually raised concerns about the safety and potential toxicity of TCM injections. [14][15][16] Most TCM products based the safety and efficacy on the long-time clinical use in the history. For many TCM injections, especially for those approved many years before, the registration requirements for evidence on safety and efficacy were much lower than conventional injections.…”

Supervisory Control of Adverse Reaction of Traditional Chinese Medicine Injection

“…Irrational use mainly includes incompatibility of drugs, repeated drug use, improper use, drug overdose, contraindications and improper selection solvent, et al The particularity of solvent also adds the incidence of adverse reactions. Intravenous drug directly into the body can stimulate the body to produce a variety of adverse reactions, especially allergic reactions [5]. Traditional Chinese medicine injection in combination with other drugs, especially multidrug share is often linked to an increased incidence of adverse reactions.…”

Detecting drug–herbal interaction using a spontaneous reporting system database: an example with benzylpenicillin and qingkailing injection

“…Literatures have given descriptions on many aspects of QI such as formulation, origin, indication, efficacy, mechanism, quality control, and safety surveillance [35][36][37][38][39][40][41][42][43]. It is made from eight kinds of herbal materials which include concha margaritifera, fructus gardenia, cornu bubali, radix isatidis, flos lonicerae, cholalic acid, hyodeoxycholic acid, and baicalin [15,38].…”