Confinement of a hydrophilic polymer in membrane lyotropic phases

López-Esparza, R.; Guedeau-Boudeville, Marie-Alice; Larios-Rodríguez, Eduardo; Maldonado, Amir; Ober, R.; Urbach, W.

doi:10.1016/j.jcis.2008.11.020

Cited by 3 publications

(3 citation statements)

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“…At such mesoscopic scale, numerous studies have shown that the structure and the physical properties of confined liquids in cavities differ strikingly from the bulk system [5][6][7][8][9][10][11][12][13][14][15][16][17][18]. The experiments on the confinement of water or associated liquid such as alcohol in mesoporous materials (aerogels, controlled pore glass, MCM-41.…”

Section: Resultsmentioning

confidence: 99%

“…Numerous investigations have been devoted on the understanding of confined water and other liquids into mesoporous materials such as MCM-41, Vycor, clay and porous silicon [5][6][7][8][9][10][11][12][13][14][15][16][17][18]. These studies have revealed effects of confinement which affect both the structure and dynamics of the confined system of which properties differ strictly from these-ones of bulk liquid [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Surfactant systems self assemble into a variety of structures which present particular organizations of the membranes and provide model system to host small or significant amounts of water for mimic confinement in biological objects [1,[19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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Confinement effects on water structure in membrane lyotropic phases

Guégan

2011

Journal of Colloid and Interface Science

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The change of the water structure in aqueous solutions of the tri-ethyleneglycol mono n-decyl ether (C(10)E(3)) was studied by micro Raman scattering. The results obtained on the O-H stretching band show that the behavior of the hydrogen bonding (H-bonds) water network can be used as a probe to follow the lamellar (L(α)) to sponge (L(3)) phase transition. In the lamellar phase, the stack of the surfactant molecules aggregated into a two-dimensional structure (membrane) acts as a soft confinement system for the H-bond water network of which the regular tetrahedral structure is perturbed. The change of the planar organization of the membranes to a highly disordered and infinite array of bilayers in the sponge phase amplifies the surface of contact between amphiphilic surfactant and water molecules which drives a strong disruption of the regular tetrahedral H-bonding water network.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Confinement effects on water structure in membrane lyotropic phases

Guégan

2011

Journal of Colloid and Interface Science

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“…Owing to this, the resulting nanostructure was strongly influenced by self-assembling properties of F127. Pure F127 in water generally forms normal micelles ( L 1 ) at room temperature, but when mixed with lipids, it competes for the curvature of the resulting phases. , Pluronic F127 and closely related poly(ethylene glycol)s generally induce sponge phase formation in cubic phase forming lipids. ,, The sponge phases containing electroformed lipid particles are called spongisomes or spongosomes. , …”

Section: Results and Discussionmentioning

confidence: 99%

Electroformation of Particulate Emulsions Using Lamellar and Nonlamellar Lipid Self-Assemblies

Bailey¹,

Prabhakaran²,

Vishwapathi³

et al. 2021

Langmuir

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We report on the development of an electroformation technique for the preparation of particulate (particle-based) emulsions. These oil-in-water (here, lipid phase acts as an "oil") emulsions were prepared using nonlamellar lipid phases. Such emulsion particles offer high hydrophobic volumes compared to conventional lipid particles based on lamellar phases (vesicles/liposomes). In addition, the tortuous internal nanostructure contributes through greater surface area per volume of lipid particles allowing an enhanced loading of payloads. The electroformation method makes use of a capacitor formed from two indium tin oxide coated conductive glass surfaces separated by a dielectric aqueous medium. This capacitor setup is enclosed in a custom-designed 3Dprinted unit. Lipid molecules, deposited on conductive surfaces, self-assemble into a nanostructure in the presence of an aqueous medium, which when subjected to an alternating current electric field forms nano-and/or microparticles. Optical microscopy, dynamic light scattering, and small-angle X-ray scattering techniques were employed for micro-and nanostructural analyses of electroformed particles. With this method, it is possible to produce particulate emulsions at a very low (e.g., 0.0005 wt % or 0.5 mg/mL) lipid concentration. We demonstrate an applicability of the electroformation method for drug delivery by preparing lipid particles with curcumin, which is a highly important but water-insoluble medicinal compound. As the method employs gentle conditions, it is potentially noninvasive for the delivery of delicate biomolecules and certain drugs, which are prone to decomposition or denaturation due to the high thermomechanical energy input and/or nonaqueous solvents required for existing methods.

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