Confined nanoparticles growth within hollow mesoporous nanoreactors for highly efficient MRI-guided photodynamic therapy

Du, Wenxian; Liu, Tianzhi; Xue, Fengfeng; Chen, Yu; Qian, Chen; Luo, Yu; Cai, Xiaojun; Ma, Ming; Chen, Hangrong

doi:10.1016/j.cej.2019.122251

Cited by 23 publications

(17 citation statements)

References 38 publications

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“…The anchored photosensitizers (PS), e.g. zinc phthalocyanine (ZnPc) and Chlorin e6 (Ce6), generate reactive oxygen species (ROS) to execute PDT in which the nanomaterials are played as light transducers [6,[16][17][18]. Although PDT assisted by these nanophotosensitiers exhibits unique advantages compared to traditional sensitizers, such as minimum invasive treatment, low side effects, no cumulative radiation dose and real-time visible diagnosis [19][20][21], the demand of external excitation light source makes it difficult for imaging and treating cancers in deep tissue.…”

Section: Introductionmentioning

confidence: 99%

Irradiation-free photodynamic therapy in vivo induced by enhanced deep red afterglow within NIR-I bio-window

Yang

Zhao

Meng

et al. 2020

Chemical Engineering Journal

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Section: Introductionmentioning

confidence: 99%

Irradiation-free photodynamic therapy in vivo induced by enhanced deep red afterglow within NIR-I bio-window

Yang

Zhao

Meng

et al. 2020

Chemical Engineering Journal

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“…In recent years, numerous nanomaterials were developed to conduct imaging-guided PDT. Various nanocarriers containing the MnO x component showed the capability of T 1 -weighted contrast imaging through Mn 2+ release, which was obtained by MnO x dissociation under the GHS or H 2 O 2 -mediated catalysis reaction in the TME [ 122 , 123 ]. Wang et al (2020) designed fibronectin-targeting iron oxide nanocarriers to carry PSs, showing an excellent homing feature in triple-negative breast cancer (TNBC) treatment and an intrinsic ability in T 2 -weighted MRI [ 124 ].…”

Section: Innovative Nanotechnologies To Improve Pdt Treatmentsmentioning

confidence: 99%

Recent Advances in Photodynamic Therapy for Deep-Seated Tumors with the Aid of Nanomedicine

Yen

et al. 2021

Biomedicines

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Photodynamic therapy (PDT) works through photoactivation of a specific photosensitizer (PS) in a tumor in the presence of oxygen. PDT is widely applied in oncology to treat various cancers as it has a minimally invasive procedure and high selectivity, does not interfere with other treatments, and can be repeated as needed. A large amount of reactive oxygen species (ROS) and singlet oxygen is generated in a cancer cell during PDT, which destroys the tumor effectively. However, the efficacy of PDT in treating a deep-seated tumor is limited due to three main reasons: Limited light penetration depth, low oxygen concentration in the hypoxic core, and poor PS accumulation inside a tumor. Thus, PDT treatments are only approved for superficial and thin tumors. With the advancement of nanotechnology, PDT to treat deep-seated or thick tumors is becoming a reachable goal. In this review, we provide an update on the strategies for improving PDT with nanomedicine using different sophisticated-design nanoparticles, including two-photon excitation, X-ray activation, targeting tumor cells with surface modification, alteration of tumor cell metabolism pathways, release of therapeutic gases, improvement of tumor hypoxia, and stimulation of host immunity. We focus on the difficult-to-treat pancreatic cancer as a model to demonstrate the influence of advanced nanomedicine in PDT. A bright future of PDT application in the treatment of deep-seated tumors is expected.

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“…The facile interconversion between Mn 2+ and Mn 4+ via Mn 3+ ensures that the process of Mn-catalyzed Fenton-like activation of H 2 O 2 is rapid and efficient. Usually, all Mn ions occur as oxide polymorphs (MnO, Mn 3 O 4 , MnOOH, and MnO 2 ), and when they are “doped” or incorporated into NPs they react efficiently with H 2 O 2 [ 49 , 50 , 51 , 52 ]. However, there are caveats associated with the different oxidation states for Mn in that physical form, since chemical composition and concentration can generate different ROS, including HO

and superoxide (O 2 − ) which are highly cytotoxic.…”

Section: Nanozyme Classification and Their Catalytic Mechanismsmentioning

confidence: 99%

Nanozymes—Hitting the Biosensing “Target”

Darland

Zhao

2021

Sensors

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Nanozymes are a class of artificial enzymes that have dimensions in the nanometer range and can be composed of simple metal and metal oxide nanoparticles, metal nanoclusters, dots (both quantum and carbon), nanotubes, nanowires, or multiple metal-organic frameworks (MOFs). They exhibit excellent catalytic activities with low cost, high operational robustness, and a stable shelf-life. More importantly, they are amenable to modifications that can change their surface structures and increase the range of their applications. There are three main classes of nanozymes including the peroxidase-like, the oxidase-like, and the antioxidant nanozymes. Each of these classes catalyzes a specific group of reactions. With the development of nanoscience and nanotechnology, the variety of applications for nanozymes in diverse fields has expanded dramatically, with the most popular applications in biosensing. Nanozyme-based novel biosensors have been designed to detect ions, small molecules, nucleic acids, proteins, and cancer cells. The current review focuses on the catalytic mechanism of nanozymes, their application in biosensing, and the identification of future directions for the field.

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Confined nanoparticles growth within hollow mesoporous nanoreactors for highly efficient MRI-guided photodynamic therapy

Cited by 23 publications

References 38 publications

Irradiation-free photodynamic therapy in vivo induced by enhanced deep red afterglow within NIR-I bio-window

Irradiation-free photodynamic therapy in vivo induced by enhanced deep red afterglow within NIR-I bio-window

Recent Advances in Photodynamic Therapy for Deep-Seated Tumors with the Aid of Nanomedicine

Nanozymes—Hitting the Biosensing “Target”

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