The difficulties of the grid electricity supplying to certain locations like far, high lands, or countryside leads to concentrate on the solutions of the renewable photovoltaic stand-alone system supported by an efficient maximum power point tracker. In addition, the difficulties of the alternating current system which are represented by a complicated controller, system size, and high cost due to the necessity of involving an inverter, a high order filter and a step up or an insulation transformer. From this point of view, this paper presents a new solution of 10.8 kW PV system which combines between the high performance of the MPPT controller and the avoiding of the alternating parts by considering direct current home appliances. A study of loads' power requirements, PV matrix design of an isolated dwelling, a full electronic design of a DC-DC boost converter with a fast response MPPT controller based on an Artificial Neural Network (ANN) which is followed by Proportional Integral (PI) controller all are presented in this paper. The simulation results are collected through MATLAB/Simulink, and the system performance is evaluated and indicated the high effectiveness in terms of harvested power.