Configuration of molecular imprinted polymer for electrochemical atrazine detection

Ahmad, Abdul Latif; Lah, Nuur Fahanis Che; Low, Siew Chun

doi:10.1007/s10965-018-1595-2

Cited by 20 publications

(11 citation statements)

References 38 publications

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“…In this complex binding site formation, dual hydrogen bonds were formed between atrazine and MAA (Ahmad, Lah and Low, 2018). The carboxylic group (-COOH) of the MAA acts as both hydrogen bond receptor and donor which interacts with the hydrogen atom of an amino group from atrazine and the nitrogen atom of the atrazine (Ahmad, Lah and Low, 2018). Based on the study, it can be observed that the molarity of the monomer can affect the binding affinity of the MIP.…”

Section: Synthesis Of Molecularly Imprintedmentioning

confidence: 92%

“…Figure 1 shows a comparison of the mechanism between covalent and non-covalent molecular imprinting. In recent studies, researchers have implemented the non-covalent bonding between the functional monomer being methacrylic acid (MAA) and template molecule being atrazine (Ahmad, Lah and Low, 2018). In this complex binding site formation, dual hydrogen bonds were formed between atrazine and MAA (Ahmad, Lah and Low, 2018).…”

Section: Synthesis Of Molecularly Imprintedmentioning

confidence: 99%

“…In recent studies, researchers have implemented the non-covalent bonding between the functional monomer being methacrylic acid (MAA) and template molecule being atrazine (Ahmad, Lah and Low, 2018). In this complex binding site formation, dual hydrogen bonds were formed between atrazine and MAA (Ahmad, Lah and Low, 2018). The carboxylic group (-COOH) of the MAA acts as both hydrogen bond receptor and donor which interacts with the hydrogen atom of an amino group from atrazine and the nitrogen atom of the atrazine (Ahmad, Lah and Low, 2018).…”

Section: Synthesis Of Molecularly Imprintedmentioning

confidence: 99%

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Review on Molecularly Imprinted Polymer (MIP) for Electrochemical Sensor Development

Rosslan

Shakhih

Amirrudin

et al. 2022

Mal. J. Fund. Appl. Sci.

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Molecularly imprinted polymers (MIPs) technology has been studied extensively for multiple applications including analyte detection and chemical separation in the field of medical, pharmaceutical, food safety, and environment. Electrochemical sensors were benefitted from MIPs technology due to their chemical and physical robustness, high sensitivity, selectivity and stability, simple fabrication process, and low-cost of production. The incorporation of MIPs has allowed the development of sensors without biological elements. However, the optimization of the imprinted products requires optimal synergistic effect of multiple factors including materials selection and synthesis techniques. This optimization will form specific recognition cavities for template molecules in the polymeric matrix. This manuscript presents a summary of various MIPs synthesis techniques and performance analysis based on recent studies. The challenges faced in MIPs technology were also discussed to help future researchers in improving technology and boosting commercialization potential against the conventional electrochemical sensor.

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Section: Synthesis Of Molecularly Imprintedmentioning

confidence: 92%

Section: Synthesis Of Molecularly Imprintedmentioning

confidence: 99%

Section: Synthesis Of Molecularly Imprintedmentioning

confidence: 99%

See 1 more Smart Citation

Review on Molecularly Imprinted Polymer (MIP) for Electrochemical Sensor Development

Rosslan

Shakhih

Amirrudin

et al. 2022

Mal. J. Fund. Appl. Sci.

View full text Add to dashboard Cite

show abstract

“…The atrazine MIP was prepared in a 7 mL glass tube by dissolving the atrazine (Atr) template in the porogen (with varying ratios of DMSO and toluene as shown in Table 1 ) [ 10 , 22 ]. The mixture was then added to a functional monomer Methacrylic acid (MAA), crosslinker Ethylene Glycol Dimethacrylate (EGDMA), and initiator (Azobisisobutyronitrile (AIBN)).…”

Section: Methodsmentioning

confidence: 99%

“…Thus, a pseudo functional material for specific recognition of target compounds by imprinting the functional groups and conformation of template molecules, known as Molecular Imprinted Polymer (MIP), has received outstanding research and application in various fields such as separation process [ 7 ], pharmaceuticals [ 8 ], sensors [ 9 , 10 , 11 ], and drug delivery [ 12 , 13 , 14 , 15 , 16 ]. This is due to its characteristics; MIPs are robust, stable, relatively inexpensive, resistant to a wide range of pH, humidity, and temperature and can be synthesized for analytes for which no natural antibody exists.…”

Section: Introductionmentioning

confidence: 99%

Isotherm and Electrochemical Properties of Atrazine Sensing Using PVC/MIP: Effect of Porogenic Solvent Concentration Ratio

et al. 2021

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Widespread atrazine use is associated with an increasing incidence of contamination of drinking water. Thus, a biosensor using molecularly imprinted polymers (MIPs) was developed to detect the amount of atrazine in water to ensure prevention of exposure levels that could lead to reproductive effects in living organisms. In this study, the influence of the porogen on the selectivity of MIPs was investigated. The porogen plays a pivotal role in molecular imprinting as it affects the physical properties and governs the prepolymerization complex of the resulting polymer, which in turn firmly defines the recognition properties of the resulting molecularly imprinted polymer (MIP). Therefore, bulk MIPs against atrazine (Atr) were synthesized based on methacrylic acid (MAA) as a functional monomer and ethyleneglycol dimethacrylate (EGDMA) as a crosslinker; they were prepared in toluene and dimethyl sulfoxide (DMSO). The imprinting factor, binding capacity, and structural stability were evaluated using the respective porogenic solvents. Along with the characterization of the morphology of the obtained polymers via SEM and BET analysis, the kinetic and adsorption analyses were demonstrated and verified. The highest imprinting factor, binding capacity, and the highest structural stability were found to be on polymer synthesized in a medium of MAA and EGDMA, which contained 90% toluene and 10% DMSO as porogen. Moreover, the response for Atr concentrations by the PVC-based electrochemical sensor was found to be at a detection limit of 0.0049 μM (S/N = 3). The sensor proved to be an effective sensor with high sensitivity and low Limit of Detection (LOD) for Atr detection. The construction of the sensor will act as a baseline for a fully functionalized membrane sensor.

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Synthesis and characterization of molecularly imprinted polymers for detection of the local anesthetic lidocaine in urine

Takahashi

Matsuda

Nakazawa

et al. 2022

Separation Science Plus

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Molecularly imprinted polymers are materials that can capture target analytes using molecular recognition. These polymers can efficiently detect trace target chemical species in biological samples, such as urine and blood, containing various matrix components. We aimed to analyze the interaction of molecularly imprinted polymers with the target molecule lidocaine, which is an amino amide pharmaceutical. Lidocaine‐templated molecularly imprinted polymers were synthesized by bulk polymerization. Gas chromatography‐mass spectrometry showed there was a strong interaction between lidocaine and the recognition site in the molecularly imprinted polymers. Non‐selective adsorption of lidocaine on the molecularly imprinted polymers was confirmed and characterized by Scatchard analysis. The washing solution was optimized for the separation of lidocaine from the structurally similar anesthetics procaine and tetracaine by taking advantage of differences in binding strength. The molecularly imprinted polymers could adsorb lidocaine in urine samples and were not affected by interfering compounds. Consequently, they could be applied to the analysis of biological materials. These results suggest that the molecularly imprinted polymers can be used for separation and detection with high selectivity and could be applied in forensic and clinical analysis.

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Configuration of molecular imprinted polymer for electrochemical atrazine detection

Cited by 20 publications

References 38 publications

Review on Molecularly Imprinted Polymer (MIP) for Electrochemical Sensor Development

Review on Molecularly Imprinted Polymer (MIP) for Electrochemical Sensor Development

Isotherm and Electrochemical Properties of Atrazine Sensing Using PVC/MIP: Effect of Porogenic Solvent Concentration Ratio

Synthesis and characterization of molecularly imprinted polymers for detection of the local anesthetic lidocaine in urine

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