Configuration control on the shape memory stiffness of molecularly imprinted polymer for specific uptake of creatinine

Ang, Qian Yee; Zolkeflay, Muhammad Helmi; Low, Siew Chun

doi:10.1016/j.apsusc.2016.02.076

Cited by 15 publications

(8 citation statements)

References 41 publications

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“…The flexibility and low density properties are advantageous since the thin film is fabricated using mild polymerization conditions without decomposition problems and guarantying excellent selectivity [55]. Other studies include the optimization of sol-gel based MIPs to recognize molecules like metabolites, proteins, cells, pesticides [61,63,64,65]. …”

Section: Polymeric Materialsmentioning

confidence: 99%

Imprinting Technology in Electrochemical Biomimetic Sensors

Frasco

Truta

Sales

et al. 2017

Sensors

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Biosensors are a promising tool offering the possibility of low cost and fast analytical screening in point-of-care diagnostics and for on-site detection in the field. Most biosensors in routine use ensure their selectivity/specificity by including natural receptors as biorecognition element. These materials are however too expensive and hard to obtain for every biochemical molecule of interest in environmental and clinical practice. Molecularly imprinted polymers have emerged through time as an alternative to natural antibodies in biosensors. In theory, these materials are stable and robust, presenting much higher capacity to resist to harsher conditions of pH, temperature, pressure or organic solvents. In addition, these synthetic materials are much cheaper than their natural counterparts while offering equivalent affinity and sensitivity in the molecular recognition of the target analyte. Imprinting technology and biosensors have met quite recently, relying mostly on electrochemical detection and enabling a direct reading of different analytes, while promoting significant advances in various fields of use. Thus, this review encompasses such developments and describes a general overview for building promising biomimetic materials as biorecognition elements in electrochemical sensors. It includes different molecular imprinting strategies such as the choice of polymer material, imprinting methodology and assembly on the transduction platform. Their interface with the most recent nanostructured supports acting as standard conductive materials within electrochemical biomimetic sensors is pointed out.

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Section: Polymeric Materialsmentioning

confidence: 99%

Imprinting Technology in Electrochemical Biomimetic Sensors

Frasco

Truta

Sales

et al. 2017

Sensors

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“…Owing to the absence of template during the preparation of NIPs, the entire binding of NIPs is presumably random. Therefore, it is expected to observe a linear increment of binding capacity when a higher concentration of template is introduced (Figure 2) because of the binding process is concentration gradient driven (Ang et al , 2016). As aforementioned, there are three factors, which give rise to the adsorption of MIPs and any porous materials (MIPs or NIPs) will contribute to some extent of binding affinity.…”

Section: Molecularly Imprinted Polymer In Diagnosticmentioning

confidence: 99%

Feasibility study on molecularly imprinted assays for biomedical diagnostics

Ang

Low

2019

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Purpose Molecularly imprinted polymers (MIPs) have aroused focus in medicinal chemistry in recent decades, especially for biomedical applications. Considering the exceptional abilities to immobilize any guest of medical interest (antibodies, enzymes, etc.), MIPs is attractive to substantial research efforts in complementing the quest of biomimetic recognition systems. This study aims to review the key-concepts of molecular imprinting, particularly emphasizes on the conformational adaptability of MIPs beyond the usual description of molecular recognition. The optimal morphological integrity was also outlined in this review to acknowledge the successful sensing activities by MIPs. Design/methodology/approach This review highlighted the fundamental mechanisms and underlying challenges of MIPs from the preparation stage to sensor applications. The progress of electrochemical and optical sensing using molecularly imprinted assays has also been furnished, with the evolvement of molecular imprinting as a research hotspot. Findings The lack of standard synthesis protocol has brought about an intriguing open question in the selection of building blocks that are biocompatible to the imprint species of medical interest. Thus, in this paper, the shortcomings associated with the applications of MIPs in electrochemical and optical sensing were addressed using the existing literature besides pointing out possible solutions. Future perspectives in the vast development of MIPs also been postulated in this paper. Originality/value The present review intends to furnish the underlying mechanisms of MIPs in biomedical diagnostics, with the aim in electrochemical and optical sensing while hypothesizing on future possibilities.

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“…Nowadays, organic materials are receiving great attention in the development of organic electronic devices like transistors, sensors, memories, diodes, and solar cells [1][2][3][4][5]. This is mainly because of their unique feature offering towards the realization of light weight, flexible, easily processable and cost effective devices for the real life applications [6,7].…”

Section: Introductionmentioning

confidence: 99%