Configuration and frequency gradient of electric slow wave over canine small bowel

Szurszewski, JH; Lr, Elveback; Cf, Code

doi:10.1152/ajplegacy.1970.218.5.1468

Cited by 84 publications

(46 citation statements)

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“…In 1899, Bayliss & Starling noticed myogenic waves of contractions with associated transit of content, in addition to their discovery of the law of the intestine, describing neural control (Bayliss & Starling, 1899). The characteristics of myogenic control have been further elucidated by many others, notably Diamant & Bortoff (1969) and Szurszewski, Elveback & Code (1970). A synthesis of myogenic and neural control mechanisms was given by Costa & Furness (1982) and Weisbrodt (1987).…”

Section: Discussionmentioning

confidence: 99%

Co‐operation between neural and myogenic mechanisms in the control of distension‐induced peristalsis in the mouse small intestine

Huizinga

Ambrous

Der–Silaphet

1998

The Journal of Physiology

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Myogenic and neural control of intestinal transit were investigated in a model of distension‐induced peristalsis. A comparison was made between the electrical and mechanical activities and outflow of contents observed in control mice and in W/W v mice, which lack the interstitial cells of Cajal associated with Auerbach's plexus. Distension caused a periodic appearance of increased motor activity due to stimulation of enteric nerves in both control and W/W v mice. Excitation was primarily delivered by cholinergic nerves, whereas periodic inhibition was mediated by neuronal nitric oxide. In control mice, outflow was driven by propagating slow‐wave activity and was only in the aboral direction. Outflow only occurred when slow waves carried sufficient action potentials to cause phasic intraluminal pressure increases of ≥ 1 cmH2O through direct stimulation of the musculature or by distension‐induced neurally mediated activation. In W/W v mice, outflow was associated with propagating action potentials that occurred due to either neural stimulation or direct muscle stimulation. Action potential propagation and outflow occurred in both oral and aboral directions. In summary, in both control and W/W v mice, distension induced periodic motor activity through stimulation of the enteric nervous system. Intraluminal contents were not moved in front of such motor activity. Rather, within such periods of activity that occurred concurrently throughout an entire segment, pulsatile outflow was directed by individual propagating slow waves with superimposed action potentials in control tissue, and by propagating action potentials in W/W v mice, which lack interstitial cells of Cajal.

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Section: Discussionmentioning

confidence: 99%

Co‐operation between neural and myogenic mechanisms in the control of distension‐induced peristalsis in the mouse small intestine

Huizinga

Ambrous

Der–Silaphet

1998

The Journal of Physiology

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“…[2][3][4] In the late 1960s and early 1970s, experiments, primarily in the canine model, began to elucidate the nature of GI myoelectrical activity and its relation to contractile activity. [5][6][7][8][9] These results and the development of techniques of myoelectrical recording were critical to further research in GI pacing. Since that time and before 1990s, there have been more reports on the applications of electrical stimulation to affect GI motility both acutely and chronically.…”

Section: Introductionmentioning

confidence: 99%

Systematic review: applications and future of gastric electrical stimulation

Zhang

Chen

2006

Aliment Pharmacol Ther

105

114

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“…However, the anatomical supports for electrical coupling between smooth muscle cells [20] provide no evidence for such an unidirectional coupling; Sarna et al [18] found that it lacked several properties of intes tinal electrical activity. They obtained a better fit to experimental data with two more sophisticated models including bilateral coupling.…”

Section: Discussionmentioning

confidence: 99%

“…D iamant and Bortoff [6] have shown that the frequency gradient varies in situ in a stepwise fashion. Sarna et al [18] and Szurszewski et al [20] described only one frequency plateau which takes place in the duodenum and proximal jejunum.…”

mentioning

confidence: 99%

The Effects of Transections on the Basic Electrical Rhythm in the Canine Jejunum

Mendel¹,

Pousse²,

Dauchel³

et al. 1976

Eur Surg Res

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The basic electrical rhythm (BER) was studied in situ in the jejunum in 14 anaesthetized mongrel dogs by the mean of six monopolar electrodes. The BER frequency was measured in the intact intestine and after proximal and distal transections of the gut 5 cm apart from the electrodes. No significant differences were found between the BER frequencies recorded by each electrode, demonstrating the existence of a frequency plateau which remained after each transection. In the intact intestine the frequency in the plateau was 13.2+0.3 cpm². After the proximal transection, this frequency dropped to 12.0+0.4 cpm (p < 0.05) and, after the distal transection, it dropped to 10.9+0.4 cpm (p < 0.05). This last frequency change shows the influence of the distal intestine on the electrical behaviour of the jejunum.

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Configuration and frequency gradient of electric slow wave over canine small bowel

Cited by 84 publications

References 0 publications

Co‐operation between neural and myogenic mechanisms in the control of distension‐induced peristalsis in the mouse small intestine

Co‐operation between neural and myogenic mechanisms in the control of distension‐induced peristalsis in the mouse small intestine

Systematic review: applications and future of gastric electrical stimulation

The Effects of Transections on the Basic Electrical Rhythm in the Canine Jejunum

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