Confidential unit exclusion at the regional blood bank in Montes Claros

Maia, Caroline Nogueira; Ruas, Munic de Oliveira; Urias, Elaine Veloso Rocha

doi:10.5581/1516-8484.20120008

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…In our study, about one-third of the donors were first-time donors. Similar results were observed in several other studies in Iran and other countries [15,17,18].…”

Section: Discussionsupporting

confidence: 92%

“…Donor selection is an important step in blood safety and different studies have revealed that suitable and appropriate donor selection can significantly improve blood safety [15,16]. It was shown that blood components of repeated and regular blood donors have a lower risk of TTI transmission than those of first-time donors [10,17,18,19,20]. On the other hand, it has been shown that first-time donors are the most common donors in blood transfusion centers [10,18].…”

Section: Discussionmentioning

confidence: 99%

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First-Time Blood Donors are Double Edged Swords for Blood Transfusion Centers: a Retrospective Study in Southwest Iran

Niazkar¹,

Dorgalaleh²,

Rad³

2019

Tjh

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Objective: First-time blood donors are the most common group of blood donors. They usually have different motivations for blood donation, some of which provoke the donors to hide risk factors of transfusion-transmissible infections (TTIs). Therefore, detection of TTIs among first-time donors is crucial and can decrease the rate of TTIs among blood recipients. This study aimed to evaluate the prevalence of TTIs among first-time donors in the transfusion center of Kohgiluyeh and Boyer-Ahmad Province (KBTC), Iran. Materials and Methods:This retrospective study was conducted with volunteer blood donors in 2004-2014 in the KBTC. Various data, including sex, confidential unit exclusion (CUE), previous donation history, and the laboratory findings of confirmatory tests, were extracted from blood donor software. Data were analyzed by SPSS using the chi-square test.Results: Among 198,501 blood donors, 52,527 (26.46%) were firsttime donors, while 145,974 donors (73.54%) were repeat and regular donors. Most of the donors (94.5%) were male, while a minority (5.5%) were female. The CUE option was chosen by 2,237 (1.13%) donors. The incidence of hepatitis B surface antigen (HBsAg) and hepatitis C virus (HCV) was 247 (0.13%) and 134 (0.07%) among the entire study population, respectively. Three donors (0.002%) had confirmed human immunodeficiency virus (HIV), while none of the blood donors were positive for syphilis. Most of the donors with positive HBsAg (95.8%), HCV (86.6%), and HIV (100%) infection were first-time donors. Conclusion:Since TTIs are more common among first-time blood donors than regular and repeat donors, special considerations should be taken into account for this common group of blood donors.Amaç: Kan donörlerinin büyük çoğunluğunu ilk kez kan veren donörler oluşturmaktadır. Bu kişilerin genellikle kan vermek için farklı motivasyonları vardır ve bu da vericilerin transfüzyon ilişkili enfeksiyonları (TTI) saklaması açısından risk oluşturur. Bu nedenle ilk kez verici olanlarda TTI'ları tespit etmek çok önemlidir ve böylece kan alıcılarında TTI'lar azaltılabilir. Bu çalışmada amaç İran'da Kohgiluyeh ve Boyer-Ahmad Bölgesi (KBTC) transfüzyon merkezindeki ilk kez verici olan kan donörlerinde TTI prevelansının araştırılmasıdır. Gereç ve Yöntemler:Bu çalışma, KBTC'de 2004-2014 yılları arasında gönüllü kan vericilerinin dahil edildiği retrospektif bir çalışmadır. Cinsiyet, gizli ünite dışlaması (CUE), daha önceki kan bağışları, ve doğrulama testlerinin laboratuvar bulguları gibi veriler, kan vericileri yazılımından elde edilmiştir. Elde edilen veriler ki-kare testi kullanılarak SPSS ile değerlendirilmiştir. : 198,501 kan vericisinden 52,527'i (%26,46) ilk kez kan veren donörler, 145,974'i ise düzenli olarak kan verenler veya daha önce kan vermis olanlardı (%73,54). Vericilerin çoğu erkekti (%94,5), kadın verciler azınlıktaydı (5,5%). CUE seçeneği 2,237 (%1,13) verici tarafından kullanılmıştı. Bütün çalışma grubunda hepatit B yüzey antijeni (HBsAg) ve hepatit C virüsü (HCV) sıklığı sırasıyla 247 (%0,13) ve 134 (%0,0...

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“…In our study, about one-third of the donors were first-time donors. Similar results were observed in several other studies in Iran and other countries [15,17,18].…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

First-Time Blood Donors are Double Edged Swords for Blood Transfusion Centers: a Retrospective Study in Southwest Iran

Niazkar¹,

Dorgalaleh²,

Rad³

2019

Tjh

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“…Previous Brazilian studies on CUE use have shown rates of CUE use ranging from 0.62% to 3.3% while in our study 0.75% donors used CUE. CUE usage rates vary according to different socio‐educational and cultural factors.…”

Section: Discussionmentioning

confidence: 47%

High rate of seromarkers for HIV, HBV and syphilis among blood donors using confidential unit exclusion, before and after HIV‐NAT implementation at a major public blood bank in the Brazilian Amazon

et al. 2018

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BACKGROUND: Confidential unit exclusion (CUE) was introduced in the 1980's as an additional layer to blood safety, before highly specific and sensitive nucleic acid tests (NAT) for HIV were implemented. The utility of CUE-use in settings that have implemented NAT should be evaluated over time. STUDY DESIGN, METHODS: Cross-sectionalretrospective study carried out from June 2010-November 2015, at Manaus Hemocenter (HEMOAM), Amazonas, Brazil that implemented HIV-NAT in 2012. The HIV, HCV, HBV, HTLV, Chagas disease, and syphilis rates were compared among CUE and non-CUE blood donors, before and after HIV-NAT implementation. RESULTS:Among 287,588 donations, 2,154 (0.75%) were associated with CUE, mainly voluntary donations (64.2%), by repeat donors (58.4%) from young (median age = 31 years), males (84.4%), unmarried (63.1%). CUE-users compared to non-CUE donors (n = 285,434) had higher seropositivity rates to HIV (OR = 6.09, 95% CI: 3.68-10.07, p < 0.001), HBV (anti-HBc OR = 1.81 95% CI: 1.24-2.64, p = 0.004; HBsAg OR = 5.68, 95% CI: 1.78-18.07, p = 0.017), and syphilis (OR = 1.78, 95% CI: 1.05-3.04, p = 0.030). Most (97.2%) discarded blood units associated to CUE was seronegative for all pathogens. Most donations (73.4%) were tested by HIV-NAT and showed four window period donations, positive by HIV-NAT only among non-CUE donors. CONCLUSION:A high rate of transfusion transmissible infections/TTIs was observed at HEMOAM especially in CUE-users. CUE-use offered an additional layer of blood safety by its association with anti-HBc/HBsAg and syphilis that are not covered by NAT. For blood banks in highly endemic areas for HIV and TTI, as HEMOAM, the identification of at risk donors, and the orientation to be tested at proper sites remain a great challenge. W orldwide safe blood transfusions have been continuously challenged by both emerging and known transfusion transmissible infections (TTIs). Brazil, the largest and most populous country in Latin America is also the most affected by HIV/AIDS. From 1980From -2017,810 AIDS cases were reported in the country. 1 In the recent decade, the Brazilian Amazon in the North region has shown an uncontrolled AIDS epidemic with growing prevalence and mortality rates. 1 This expansion sharply contrasts with a stable epidemic with decreased prevalence and mortality in its epicenter, located in Southeast Brazil. 1 A recent 21-year historical series from a major public blood bank from Amazonas State, the Hematology and Hemotherapy Foundation of Amazonas State (HEMOAM), described a significant rate of HIV infection in young male donors, suggesting high-risk, test-seeker behavior and potential risk of HIV transmission by blood transfusion. 2 In the isolated geographic context of Amazonas state where there is a high demand for blood transfusions, the control of an expanding AIDS epidemic and the implementation of safe transfusion procedures are both challenging and represent a critical component for the public health network.From the

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“…( 4 ) During the last few years, several studies have been performed in an attempt to analyze the epidemiologic profile of self-excluding donors in Brazil as in the case of the article of the Regional Blood bank in Montes Claros, Minas Gerais State, Southeast Brazil published in this issue. ( 5 )…”

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confidence: 99%

Comments on confidential unit exclusion at the Regional Blood bank in Montes Claros

Vogler

2012

Rev. Bras. Hematol. Hemoter.

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Confidential unit exclusion at the regional blood bank in Montes Claros

Cited by 5 publications

References 16 publications

First-Time Blood Donors are Double Edged Swords for Blood Transfusion Centers: a Retrospective Study in Southwest Iran

First-Time Blood Donors are Double Edged Swords for Blood Transfusion Centers: a Retrospective Study in Southwest Iran

High rate of seromarkers for HIV, HBV and syphilis among blood donors using confidential unit exclusion, before and after HIV‐NAT implementation at a major public blood bank in the Brazilian Amazon

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