Confertin and scopoletin from leaf and root extracts of Hypochaeris radicata have anti-inflammatory and antioxidant activities

Senguttuvan, Jamuna; Krishnamoorthy, Karthika; Paulsamy, S.; Krishnaswamy, Thenmozhi; S, Kathiravan .; Venkatesh, R.

doi:10.1016/j.indcrop.2015.03.039

Cited by 55 publications

(34 citation statements)

References 37 publications

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“…Corroborating our findings, the reduction of TNF-α and IL-1β by scopoletin was recently demonstrated in a carrageenan-induced paw oedema model in rats [40].…”

Section: Discussionsupporting

confidence: 90%

Inhibition of the NF-κB and p38 MAPK pathways by scopoletin reduce the inflammation caused by carrageenan in the mouse model of pleurisy

Nascimento

Arruda‐Silva

Luz

et al. 2016

Immunopharmacology and Immunotoxicology

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Natural products have long been used worldwide as therapeutic agents, but it is only recently, in response to the new challenges posed by global population aging, that interest in research into potentially therapeutic natural products has reemerged. In this context, coumarins, chemical compounds found in plants that have known anti-inflammatory activity, are promising candidates for the development of new drugs. In this study we test the effect of scopoletin, a coumarin found in several plant species, on carrageenan-induced inflammation in the mouse model of pleurisy. Initially, the effects of scopoletin on leukocyte migration and exudate concentrations were evaluated at three different doses (0.1, 1 and 5 mg/kg) and time (0.5-4 h before pleurisy). In the next step, we chose the lowest dose capable of inhibiting the inflammatory parameters (1 mg/kg), in order to analyze the myeloperoxidase and adenosine deaminase activities, the nitric oxide, tumor necrosis factor-α, and interleukin 1β levels in the fluid leakage, and the p65 subunit of NF-κB and p38 MAPK phosphorylation. Scopoletin at a dose of 1 mg/kg was able to significantly reduce cell migration and exudation to the pleural fluid (p < 0.01). Scopoletin at the same dose also decreased the myeloperoxidase and adenosine-deaminase activities and nitric oxide, tumor necrosis factor-α, and interleukin-1β levels (p < 0.01). In addition, it significantly reduced p65 and p38 phosphorylation in the mouse lungs (p < 0.01). Our results reinforce that scopoletin has important anti-inflammatory activity, and shows, that this effect can be attributed to the ability of this compound to inhibit the phosphorylation of NF-κB and p38 MAPK.

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“…Corroborating our findings, the reduction of TNF-α and IL-1β by scopoletin was recently demonstrated in a carrageenan-induced paw oedema model in rats [40].…”

Section: Discussionsupporting

confidence: 90%

Inhibition of the NF-κB and p38 MAPK pathways by scopoletin reduce the inflammation caused by carrageenan in the mouse model of pleurisy

Nascimento

Arruda‐Silva

Luz

et al. 2016

Immunopharmacology and Immunotoxicology

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“…It may be due to the presence of suitable physical and chemical conditions of respective potting media for the survivability of these study species. The same hardening medium compositions were used by Jamuna and Paulsamy (25,26) for the growth of the medicinal plant, Hypochaeris radicata. These specific hardening media was also recommended for the micropropagation of epicotyl explants of the study species, Coscinium fenestratum for better survival in the field and they were morphologically similar to the mother plants (19).…”

Section: Discussionmentioning

confidence: 99%

Direct Organogenesis of a Critically Endangered Medicinal Liana, Coscinium Fenestratum (Gaertn.) Colebr. (Menispermaceae)

Karthika¹

2019

krj

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An efficient and reproducible regeneration protocol via direct organogenesis has been established using nodal explants of Coscinium fenestratum. Nodal explants were inoculated on MS medium supplemented with BAP and TDZ at 2.0 and 1.0mg/L respectively were produced high frequency of shoots (91.01%). The elongated shoots subcultured on half strength MS medium supplemented with IBA alone at 0.6mg/L produced high frequency of roots (97.42%). Rooted plantlets were acclimatized and established in garden soil, sand and vermicompost in the ratio 1:1:1 with good survival rate under greenhouse conditions. This protocol can be efficiently used for mass multiplication and conservation of this critically endangered medicinal liana in its native habitat.

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“…In contrast to the limitations of NSAIDs, natural products have a more favorable pharmacological profile accompanied by lower toxicities. Additionally, natural products are biocompatible and cost effective alternatives for the treatment of various inflammatory diseases 14, 15, 16. Anti-inflammatory drug discovery from plants is the most productive and rational strategy for the identification of novel drug candidates 9 .…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory activity of bartogenic acid containing fraction of fruits of Barringtonia racemosa Roxb. in acute and chronic animal models of inflammation

Patil

2017

Journal of Traditional and Complementary Medicine

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The fruits of Barringtonia racemosa are traditionally used in Indian medicine for the treatment of pain and inflammatory conditions. In this study, a fraction of ethyl acetate extract of fruits of B. racemosa (BREAF) was investigated for anti-inflammatory activity in experimental models of acute and chronic inflammation. Activity against acute inflammation was evaluated in inflammogens induced rat paw edema models. Whereas, effect in chronic inflammation was evaluated in cotton pellet granuloma and oxazolone induced delayed type hypersensitivity (DTH) model in mice. The BREAF exhibited dose dependent anti-inflammatory activity in both acute and chronic models at oral doses of 5, 10 and 20 mg/kg. BREAF inhibited both phases of carrageenan induced rat paw inflammation. The reduction in paw inflammation by BREAF was also evident in histamine and serotonin induced inflammation in rats. Effect of BREAF on DTH indicates inhibition of immune mediated inflammation. The reduction in cotton pellet granuloma by BREAF treatment shows inhibition of proliferative changes associated with chronic inflammation. Analysis of BREAF after chromatographic separations showed presence of bartogenic acid as a major constituent. Hence, it is proposed that anti-inflammatory effects of BREAF can be partially attributed to its bartogenic acid content. The minute doses at which this fraction shows anti-inflammatory effects emphasizes the need for further investigations on its efficacy in the immuno-inflammatory conditions.

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Confertin and scopoletin from leaf and root extracts of Hypochaeris radicata have anti-inflammatory and antioxidant activities

Cited by 55 publications

References 37 publications

Inhibition of the NF-κB and p38 MAPK pathways by scopoletin reduce the inflammation caused by carrageenan in the mouse model of pleurisy

Inhibition of the NF-κB and p38 MAPK pathways by scopoletin reduce the inflammation caused by carrageenan in the mouse model of pleurisy

Direct Organogenesis of a Critically Endangered Medicinal Liana, Coscinium Fenestratum (Gaertn.) Colebr. (Menispermaceae)

Anti-inflammatory activity of bartogenic acid containing fraction of fruits of Barringtonia racemosa Roxb. in acute and chronic animal models of inflammation

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