Conessine as a larval growth inhibitor, sterilant, and antifeedant from Holarrhena antidysenterica Wall

Thappa, R. K.; Tikku, K.; Saxena, B. P.; Vaid, R. M.; Bhutani, K. K.

doi:10.1017/s1742758400010304

Cited by 8 publications

(9 citation statements)

References 16 publications

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“…described the growth inhibitor, sterilant, and antifeedant activity of conessine in Aedes aegypti , Dysdercus koenigii , Spodoptera litura , and Pieris brassicae . [ 26 ]…”

Section: Drug Characterizationmentioning

confidence: 99%

Review of Holarrhena antidysenterica (L.) Wall. ex A. DC.: Pharmacognostic, pharmacological, and toxicological perspective

Jamadagni¹,

Pawar²,

Jamadagni³

et al. 2017

Phcog Rev

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“…described the growth inhibitor, sterilant, and antifeedant activity of conessine in Aedes aegypti , Dysdercus koenigii , Spodoptera litura , and Pieris brassicae . [ 26 ]…”

Section: Drug Characterizationmentioning

confidence: 99%

Review of Holarrhena antidysenterica (L.) Wall. ex A. DC.: Pharmacognostic, pharmacological, and toxicological perspective

Jamadagni¹,

Pawar²,

Jamadagni³

et al. 2017

Phcog Rev

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“…The large number of phytoconstituents was found in various parts of HP such as conessine, conkurchine, kurchine, pyrrolizidine, holarrhemine, holarrhenine, kurchicine and conkurchinin. Consessine is reported to have sterilant, antifeedant and growth inhibitory effect 13,14 .The steroidal alkaloid of HP has also been found to decrease the acetylcholinesterase activity 15 . Another earlier study by Chaturvedi and Singh suggested that the HP bark powder induced numerous side effects such as nausea, nervousness, insomnia, flatulence, constipation, syncope, vertigo, fatigue, xerostomia, anxiety and body lightness 14 .…”

Section: Introductionmentioning

confidence: 99%

“…Consessine is reported to have sterilant, antifeedant and growth inhibitory effect 13,14 .The steroidal alkaloid of HP has also been found to decrease the acetylcholinesterase activity 15 . Another earlier study by Chaturvedi and Singh suggested that the HP bark powder induced numerous side effects such as nausea, nervousness, insomnia, flatulence, constipation, syncope, vertigo, fatigue, xerostomia, anxiety and body lightness 14 . HP bark isolated steroidal alkaloid conessine showed high activity against malaria 16 .…”

Section: Introductionmentioning

confidence: 99%

GC-MS Analysis of Bioactive Compounds and Safety Assessment of the Ethanol Extract of the Barks of Holarrhena pubescens Wall. ex.G.Don (Family Apocynaceae): Sub-Acute Toxicity Studies in Swiss Albino Mice

Namasudra¹,

Phukan²,

Bawari³

2021

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Background: Holarrhena pubescens Wall. ex G. Don belongs to the family Apocynaceae and has several therapeutic applications in traditional medicine. This plant has various pharmacological properties such as antihelmintic, antidiuretic and antidiabetic. One of the major concerns, as they are used, is the lack of adequate pharmacological and toxicological data to support their uses. Objective: The present investigation was carried out to evaluate the safety of an ethanolic extract of Holarrhena pubescens Wall.ex.G.Don (Apocynaceae) by determining its potential toxicity after oral administration for 28 days. Methods: In sub-acute toxicity, the extract at the doses of 250, 500 and 1000mg/kg, bw was administered orally for 28 days. After 28 days of treatment, the mice were decapitated; brain was homogenized for evaluating oxidative stress. The brain was fixed in 10 % formalin and processed for histopathological examinations. Phytochemical analysis of the plant extract was performed by (GC-MS). Result: In the sub-acute study in mice, daily oral administration of HP resulted in a significant increase in the lipid peroxidation of treated animals and a decrease in enzymes activity of CAT, SOD, GPX and GR in both, males and females mice. Histopathological analysis showed alterations in the mice brain cortex. From the GC-MS analysis of the plant extract, it was evident that major phytochemicals were present in the ethanol extract of HP. Some major phytochemicals namely, conessimine (17.81 %); lup-20(29)-en-3-one (16.50%); piperidine, 2-(tetrahydro-2-furanyl)-(6.44%); lup-20(29)-ene-3, 28-diol, (3.beta.) (4.82%) and 17-(1, 5-dimethyl-3-phenylsulfanyl-hex-4-enyl (4.37%) were found. Conclusion: H.pubsecne bark ethanol extract was found to be relatively safe in lower doses although at higher doses it can cause lipid peroxidation and damage to the neuronal cell of the brain and should therefore be used with caution.

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“…The stem bark of the H. antidysenterica plant, commercially known as kurchi and kutaz in the Indian subcontinent has been investigated due to its traditional use in the treatment of amoebic dysentery, diarrhoea, asthma, bronchopneumonia [ 9 , 10 ]. In addition the plant has been reported to possess anti-helminthic, appetizing, anti-diarrhoeal, astringent properties [ 11 ], used as an immunomodulating agent [ 12 ], larval growth inhibitor [ 13 ] and against vaginitis [ 14 ]. Gaur [ 15 ] reported that the bark of the H. antidysenterica is used against malaria in the Garhwal region of north-west Himalaya.…”

Section: Introductionmentioning

confidence: 99%

Anti-malarial activity of Holarrhena antidysenterica and Viola canescens, plants traditionally used against malaria in the Garhwal region of north-west Himalaya

Verma

Dua

Agarwal

et al. 2011

Malar J

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BackgroundThe increasing number of multidrug-resistant Plasmodium strains warrants exploration of new anti-malarials. Medicinal plant research has become more important, particularly after the development of Chinese anti-malarial drug artemisnin from Artemisia annua. The present study shows evaluation of anti-malarial effects of two plants commonly used against malaria in the Garhwal region of north-west Himalaya, in order to discover the herbal-based medicine.MethodsIn vitro anti-plasmodial sensitivity of plant extracts was assessed using schizont maturation and parasite lactate dehydrogenase (pLDH) assay. Cytotoxic activities of the examined extracts were determined on L-6 cells of rat skeletal muscle myoblast. The 4-day test for anti-malarial activity against a chloroquine sensitive Plasmodium berghei NK65 strain in Swiss albino mice was used for monitoring in vivo activity of plant extracts.ResultsChloroform extract of H. antidysenterica (HA-2) and petroleum ether extract of V. canescens (VC-1) plants significantly reduced parasitaemia in P. berghei infected mice. The extract HA-2 showed in vitro anti-plasmodial activity with its IC50 value 5.5 μg/ml using pLDH assay and ED50 value 18.29 mg/kg in P. berghei infected Swiss albino mice. Similarly petroleum ether extract of V. canescens (VC-1) showed in vitro anti-plasmodial activity with its IC50 value 2.76 μg/ml using pLDH assay and ED50 15.8 mg/kg in P. berghei infected mice. The extracts coded as HA-2 at 30 mg/kg and VC-1 at 20 mg/kg exhibited parasite inhibition in mice: 73.2% and 63.0% respectively. Of these two plant extracts, petroleum ether extract of V. canescens was found slightly cytotoxic.ConclusionThe present investigation reflects the use of these traditional medicinal plants against malaria and these plants may work as potential source in the development of variety of herbal formulations for the treatment of malaria.

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Conessine as a larval growth inhibitor, sterilant, and antifeedant from Holarrhena antidysenterica Wall

Cited by 8 publications

References 16 publications

Review of Holarrhena antidysenterica (L.) Wall. ex A. DC.: Pharmacognostic, pharmacological, and toxicological perspective

Review of Holarrhena antidysenterica (L.) Wall. ex A. DC.: Pharmacognostic, pharmacological, and toxicological perspective

GC-MS Analysis of Bioactive Compounds and Safety Assessment of the Ethanol Extract of the Barks of Holarrhena pubescens Wall. ex.G.Don (Family Apocynaceae): Sub-Acute Toxicity Studies in Swiss Albino Mice

Anti-malarial activity of Holarrhena antidysenterica and Viola canescens, plants traditionally used against malaria in the Garhwal region of north-west Himalaya

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