Cone milling of compacted flakes: Process parameter selection by adopting the minimal fines approach

Samanta, Asim Kumar; Ng, Kwun Kei; Heng, Paul Wan Sia

doi:10.1016/j.ijpharm.2011.10.015

Cited by 27 publications

(10 citation statements)

References 8 publications

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“…Also, oscillating mode (clockwise/counter-clockwise) produces higher throughput than rotation (clockwise). Regarding the milling speed, it was reported in the literature [20] that, in general, when the milling speed is increased, the percentage of fines is increased as well. Nevertheless, the determination of the optimal milling parameters for both excipients is difficult, because there is not a clear tendency in the results and the performance depends not only on the milling conditions but also on the roll-compaction conditions.…”

Section: Granules Size Distributionmentioning

confidence: 99%

“…During die filling, particle size distribution has a direct effect on the segregation of particles inside the die and this can create afterwards a gradient of tablet density and a heterogeneity of the API content. It was reported in the literature that different milling systems and impellers can drive to different milling mechanisms [20]. But, is there any effect of the milling system on the mechanical properties of granules under compression?…”

Section: How Do Milling-conditions Affect the Compactability Of Tablets?mentioning

confidence: 99%

“…Some authors have reported research work on the effect of the milling on granules properties. Samanta et al [20] evaluated the effect of conical mill process parameters and concluded that the type of impeller and the screen are the settings with the highest influence on the granule size distribution. On the other hand, Vendola and Hancock [21] compared four types of milling systems for two dry-granulated placebo formulations; the evaluation was done based on the compactability, resulting that the mill type and the granulation size distribution did not greatly influence the compactability of tablets.…”

Section: Introductionmentioning

confidence: 99%

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Effect of roll-compaction and milling conditions on granules and tablet properties

Pérez-Gandarillas

Perez-Gago

Mazor

et al. 2016

European Journal of Pharmaceutics and Biopharmaceutics

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Dry granulation is an agglomeration process used to produce size-enlarged particles (granules), improving the handling properties of powders such as flowability. In this process, powders are compacted using a roll press to produce ribbons, which are milled in granules used further in the tableting process. The granule and tablet properties are influenced by the existence of different designs of the roll compactors, milling systems and the interaction between process parameters and raw material properties. The main objective of this work was to investigate how different roll-compaction conditions and milling process parameters impact on ribbons, granules and tablet properties, highlighting the role of the sealing system (cheek plates and rimmed roll). In this context, two common excipients differing in their mechanical behaviour (MCC and mannitol) are used. The study is based on the analysis of granule size distribution together with the characterization of loss of compactability during die compaction. Results show that the tensile strength of tablets is lower when using granules than when the raw materials are compressed. Moreover, the plastic material (MCC) is more sensitive than the brittle one (mannitol). Regarding the roll-force, it is observed that the higher the roll force, the lower the tensile strength of tablets from granulated material is. These findings are in agreement with the literature. The comparison of sealing systems shows that the rimmed-roll system leads to slightly stronger tablets than the use of cheek plates. In addition, the use of the rimmed-roll system reduces the amount of fines, in particular when high roll force is applied. Overall, it can be concluded that roll-compaction effect is predominant over the milling effect on the production of fines but less significant on the tablet properties. This study points out that the balance between a good flowability by reducing the amount of fines and appropriate tablet strength is achieved with rimmed-roll and the highest roll-force used.

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Section: Granules Size Distributionmentioning

confidence: 99%

Section: How Do Milling-conditions Affect the Compactability Of Tablets?mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of roll-compaction and milling conditions on granules and tablet properties

Pérez-Gandarillas

Perez-Gago

Mazor

et al. 2016

European Journal of Pharmaceutics and Biopharmaceutics

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“…Experimental studies have shown that screen size, impeller speed and impeller shape can be varied to affect granule size distribution [66,69]. It has also been demonstrated that decreasing screen size coupled with increased impeller speed results in smaller granule size [70].…”

Section: Millingmentioning

confidence: 99%

Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms

2013

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Abstract:The objective of this work is to present a review of computational tools and models for pharmaceutical processes, specifically those for the continuous manufacture of solid dosage forms. Relevant mathematical methods and simulation techniques are discussed, as is the development of process models for solids-handling unit operations. Continuous processing is of particular interest in the current study because it has the potential to improve the efficiency and robustness of pharmaceutical manufacturing processes.

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“…The effect of roll compaction process parameters such as roll force, sealing system design (which limits the loss of powder during the compaction) and milling conditions on ribbon, granules and tablets properties had been widely reported in the literature [2][3][4][5][6][7]. These process parameters are considered as the important parameters affecting the mechanical properties of the granules which ultimately affect their compressibility and compactibility [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Analysis of densification mechanisms of dry granulated materials

Uniyal

Gandarillas

Michrafy

et al. 2020

Advanced Powder Technology

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Dry granulation by roll compaction is a continuum manufacturing process to produce granules with improved flowability which can further be easily used in tableting process. However, the granules are non-homogeneous in density and have non-spherical shapes which impact their densification behaviour during die-compaction. The aim of this study was to investigate both the densification mechanism and the failure strength of granules of microcrystalline cellulose (MCC) and mannitol using Cooper-Eaton and Adams models. For both materials, the Cooper-Eaton approach led to the quantification of fractional volume compaction by particle rearrangement and by plastic deformation respectively to explain the difference in densification behaviour of raw material and granules. Moreover, the model showed its ability to capture the effect of granule density and granule sizes and to differentiate the densification mechanisms of MCC as a plastic material and mannitol as a brittle material. The Adams model was used to compute the failure strength of single granule from in-die compression data. The obtained results of the granules were in the range [0.6-1.43 MPa]. However, regarding the effect of granule density, the model showed mixed results indicating that the model is not representative of the studied granules which are not spherical and have a relatively wide range of sizes, nevertheless, the model was derived for near spherical particles with a narrow size distribution.

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Cone milling of compacted flakes: Process parameter selection by adopting the minimal fines approach

Cited by 27 publications

References 8 publications

Effect of roll-compaction and milling conditions on granules and tablet properties

Effect of roll-compaction and milling conditions on granules and tablet properties

Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms

Analysis of densification mechanisms of dry granulated materials

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