Cone-driven, geniculo-cortical responses in canine models of outer retinal disease
Huseyin O. Taskin,
Jacqueline Wivel,
Gustavo D. Aguirre
et al.
Abstract:PurposeCanine models of inherited retinal degeneration are used for proof-of-concept of emerging gene and cell-based therapies that aim to produce functional restoration of cone-mediated vision. We examined functional MRI measures of the post-retinal response to cone-directed stimulation in wild type (WT) dogs, and in three different retinal disease models.MethodsTemporal spectral modulation of a uniform field of light around a photopic background was used to target the canine L/M (hereafter “L”) and S cones a… Show more
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