Condylomatous Lesions of the Cervix. Ii. Cytologic, Colposcopic and Histopathologic Study

Meisels, A; Fortin, R; Roy, Michel

doi:10.1097/00006254-197803000-00023

Cited by 96 publications

(131 citation statements)

References 0 publications

Supporting

Mentioning

117

Contrasting

Unclassified

Order By: Relevance

“…Though the p16 staining is a useful marker for dysplastic squamous cells and/or spinous carcinomas, it may be of reduced sensitivity for the detection of glandular dysplasias and/ or endocervical carcinomas originating from cylindrical epithelium cells [44]. Along with the discovery of vaginal HPV infection, the term condyloma acuminatum was introduced to describe the predominantly benign vaginal/cervical lesions characterized by viral cytopathic changes (koilocytes) and/or hyperplasia of the basal and parabasal epithelium cells [45][46][47]. Nevertheless, it has turned out that it is impossible to differentiate, using classical histology, between mild cervical lesions caused by LR-HPV types (such as HPV 6 or 11) and/or the early stages in the lesions caused by HR-HPV [48].…”

Section: Overexpression Of the P16/ink4a Polypeptide In Hpv Transformmentioning

confidence: 99%

Diagnostic role of p16/INK4A protein in Human Papillomavirus (HPV) induced cervical dysplasia

Rajčáni¹,

Adamkov²,

et al. 2010

Open Life Sciences

View full text Add to dashboard Cite

Abstract:The p16/INK4A protein is a cellular regulatory polypeptide over-expressed in the presence of high levels of the Human Papillomavirus (HPV) coded E7 protein. This review outlines the use of p16 antigen staining in cervical biopsies as well as in PAP smears summarizing the corresponding literature and commenting the authors' own experience. The p16 antigen is a reliable marker for dysplastic cells in CINII/CINIII (HSIL) lesions as viewed in cervical biopsies. When PAP smears were examined at large scale screening for p16 antigenreactive and atypical cells, considerable variations could be found especially in ASCUS graded lesions. Therefore, the presence of p16-reactive atypical cells in PAP smears should be interpreted together with the cytological signs of dysplasia, such as the altered N/C ratio. In addition, women revealing p16-positive ASCUS/LSIL specimens should be examined for the presence of HPV DNA. Detection of HPV DNA alone, i.e. in the absence of cytological screening has a low predictive value, since the clearance of HPV may occur even in the absence of morphological alterations. Combined cytological as well as molecular follow up contributes to the efficiency of diagnostic and increases the probability of correct interpretation of the pre-cancerous lesions by non-invasive techniques.

show abstract

Section: Overexpression Of the P16/ink4a Polypeptide In Hpv Transformmentioning

confidence: 99%

Diagnostic role of p16/INK4A protein in Human Papillomavirus (HPV) induced cervical dysplasia

Rajčáni¹,

Adamkov²,

et al. 2010

Open Life Sciences

View full text Add to dashboard Cite

show abstract

“…If it is accepted that some types of HPV infection can cause "koilocytotic atypia" (Koss, 1979;Meisels et al, 1977) then, since such lesions will often* be classified as "dysplastic", HPV can indeed cause at least one category of "dysplasia". But, is this category of dysplasia that is produced by HPV Although these uncertainties are substantial, they do not entirely eclipse our findings.…”

Section: Subsequent Cytological Findingsmentioning

confidence: 99%

“…papillomatous) warts (Meisels et al, 1977). However, although papillomatous warts provide specific evidence of HPV infection, it is not known to what extent koilocytotic atypia does likewise.…”

mentioning

confidence: 99%

“…* Difficulties in assessing HPV infection of the cervix When attention was restricted to clinical papillomatous warts, HPV infection of the cervix itself was thought to be very rare. If, however, all of its possible manifestations (including flat warts and/or koilocytotic atypia) are included, then among large series of asymptomatic women attending cervical screening clinics at least 1% appear to have cytological evidence suggestive of such infections (Reid et al, 1980;Meisels et al, 1977). Moreover among women with frank warts elsewhere in the genital tract, such cytological or histological changes in the cervix may be detected in 10-50% (Jagella & Stegner, 1974;Purola & Savia, 1977;Baggish, 1980).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Genital warts and cervical neoplasia: An epidemiological study

Franceschi¹,

Doll²,

Gallwey³

et al. 1983

Br J Cancer

View full text Add to dashboard Cite

Summary Cervical carcinoma and cervical intra-epithelial neoplasia (CIN) are likely to be associated with all sexually transmitted diseases (STDs). To help discover which (if any) of the recognised STDs might actually cause these conditions, a key question is whether one particular such association is much stronger than the others. The present study is therefore only of women newly attending an STD clinic, and compares the prevalences of cytological abnormalities of the cervix among 415 women attending with genital warts, 135 with genital herpes, and 458 with trichomoniasis or gonorrhoea. Significantly more genital wart patients (8.1%) than trichomoniasis or gonorrhoea patients (1.9%) showed dyskaryotic changes (adjusted relative risk (RR)=5.8 with 95% limits 2.5-13.5) at, or a few months before, first attendance, while no excess whatever was seen in women with genital herpes. Moreover, half the women had a subsequent smear (at an average of 3-4 years after first attendance) and, although the diagnosis at first attendance was not related to the onset rate of dyskaryotic changes observed in these subsequent smears, it was related to the onset rate of grade III cervical intra-epithelial neoplasia (CIN III), which was found in 7 previous genital wart patients, in 2 previous trichomonas patients, but in 0 previous genital herpes patients. Thus, our findings suggest that herpes is not directly relevant to dyskaryotic change, but that one or more of the human papilloma viruses that cause genital warts may be.

show abstract

“…Human papilloma virus (HPV), which is the most common viral sexually transmitted disease in the United States (Hoskins et al, 1992), has since 1977 been considered an aetiologic agent for cervical cancer (Meisels et al, 1977) and is currently unequivocally linked with the development of precancerous lesions of the cervix. High-risk HPV subtypes are associated with the presence of highgrade squamous intraepithelial lesion (HSIL) or CIN2 -3 (Baron and Richart, 1970).…”

mentioning

confidence: 99%

Clinical and economic benefit of HPV-load testing in follow-up and management of women postcone biopsy for CIN2–3

et al. 2003

View full text Add to dashboard Cite

This study aimed to evaluate the clinical and economic implications of integrating human papilloma virus (HPV) load testing into the follow-up and management protocol of women postconisation for high-grade cervical intraepithelial neoplasia (CIN2 -3). We evaluated 130 suitable women: 63 were screened biannually by Pap smears ('conventional approach') and 67 also had HPV-load testing ('HPV approach'). More stringent criteria for undergoing colposcopy or reconisation were observed by the former group compared to the latter. Both approaches were analysed for cost effectiveness. There were 33 out of 67 (49.2%) colposcopic referrals and 24 out of 67 (35.8%) reconisation/hysterectomies with the 'conventional approach' compared to 9 out of 63 (14.2%) and 7 out of 63 (11.1%) with the 'HPV approach'. Cervical intraepithelial neoplasia 2 -3 residual disease was detected in 7 out of 67 (10.5%) and 7 out of 63 (11.1%) women. The 'conventional approach' had more negative colposcopic biopsies and more negative reconisation/hysterectomy histologies than the 'HPV approach'. The respective cost per detection of one case of residual disease was US$3573 and US$3485. The 'HPV approach' required fewer colposcopic and reconisation procedures to detect one case of residual CIN2 -3. Its higher positive predictive value than that of cytology provided a significant decrease in false positive rates and a reduction of US$88 per detected case.

show abstract

Condylomatous Lesions of the Cervix. Ii. Cytologic, Colposcopic and Histopathologic Study

Cited by 96 publications

References 0 publications

Diagnostic role of p16/INK4A protein in Human Papillomavirus (HPV) induced cervical dysplasia

Diagnostic role of p16/INK4A protein in Human Papillomavirus (HPV) induced cervical dysplasia

Genital warts and cervical neoplasia: An epidemiological study

Clinical and economic benefit of HPV-load testing in follow-up and management of women postcone biopsy for CIN2–3

Contact Info

Product

Resources

About