Condylomata gigantea in anal and perianal region: surgical and CO2 laser treatment

Perisić, Z; Lazic, Jelena Popovic; Terzić, Branka; Perisić, S; Rasic, Rajko

doi:10.1007/s00404-002-0468-3

Cited by 24 publications

(5 citation statements)

References 6 publications

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“…This tumor presents as a slow-growing, large, cauliflower-like tumor with locally destructive behavior by compressing and displacing underlying tissues rather than infiltrating or invading [45]. This tumor is associated with HPV6 and HPV11 and immunosuppression is a strong risk factor [46]. BLTs have been found more often in patients with HIV infection, history of organ transplant, hematologic malignancy, prolonged steroid use, diabetes, during pregnancy, and in persons with alcohol abuse [47,48,49].…”

Section: Anogenital Lesions In Immunosuppressionmentioning

confidence: 99%

HPV Carcinomas in Immunocompromised Patients

Reusser

Downing

Guidry

et al. 2015

JCM

114

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Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide and can result in pre-malignancies or overt malignancies of the skin and mucosal surfaces. HPV-related illnesses are an important personal and public health problem causing physical, mental, sexual and financial detriments. Moreover, this set of malignancies severely affects the immunosuppressed population, particularly HIV-positive patients and organ-transplant recipients. There is growing incidence of HPV-associated anogenital malignancies as well as a decrease in the average age of affected patients, likely related to the rising number of high-risk individuals. Squamous cell carcinoma is the most common type of HPV-related malignancy. Current treatment options for HPV infection and subsequent disease manifestations include imiquimod, retinoids, intralesional bleomycin, and cidofovir; however, primary prevention with HPV vaccination remains the most effective strategy. This review will discuss anogenital lesions in immunocompromised patients, cutaneous warts at nongenital sites, the association of HPV with skin cancer in immunocompromised patients, warts and carcinomas in organ-transplant patients, HIV-positive patients with HPV infections, and the management of cutaneous disease in the immunocompromised patient.

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Section: Anogenital Lesions In Immunosuppressionmentioning

confidence: 99%

HPV Carcinomas in Immunocompromised Patients

Reusser

Downing

Guidry

et al. 2015

JCM

114

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“…27 Conversely, if warts are located in the urethra, the CO 2 laser and cryotherapy could often cause stenosis and oedema respectively. [38][39][40][41] Two/three weeks after the treatment, the patients could return to normal sexual activity, with a considerable degree of satisfaction due to fast functional recovery. According to the PGI-I questionnaire, all patients evaluated their post-operative condition as "very much better" or "much better" and only 2/60 (3.3%) referred to mild and transient burning according to DLQI.…”

Section: Discussionmentioning

confidence: 99%

Holmium:YAG Laser for the Treatment of Genital and urethral Warts: Multicentre Prospective Evaluation of Safety and Efficacy

et al. 2021

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Introduction: Genital condylomatosis is a highly contagious disease caused by the human papilloma virus (HPV). The aim of this prospective multicentre study was to evaluate the safety and efficacy of the Holmium:YAG (yttrium-aluminium-garnet) laser in the treatment of genital and intra-urethral warts; the secondary aim was to assess the patients’ postoperative satisfaction and cosmetic results. Methods: From December 2016 to March 2019, patients with genital warts were prospectively enrolled in three hospitals. The inclusion criteria were male gender, age over 18 years-old and treatment-naïve. External and urethral genitalia warts were treated by the Holmium YAG laser. The follow-up analysis consisted of physical examination, flexible urethro-cystoscopy in case of meatal lesions, and administration of Dermatology Quality of Life Index (DLQI) and Patient Global Impression of Improvement (PGI-I) questionnaires at 1, 3, 6 and 12 months after surgery and subsequently yearly. Results: Sixty patients were enrolled. The single treatment was effective in 57/60 patients (95%). At a mean follow-up of 26 months, recurrences occurred in 8 patients (13.3%). No peri- or post-operative complication occurred. An improvement in pre-operative condition was highlighted with PGI-I and DLQI questionnaires. Conclusion: Our prospective multicentre study showed that holmium laser surgery seems to be a safe and effective treatment for external genital and urethral warts. Good dermatological outcomes aid to further improve patient satisfaction.

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“…4, 16 Most authors prefer to excise larger lesions and to reserve laser beam, especially CO2, for minute yet visible lesions, or as an adjuvant procedure after the completion of surgical excision. 25 The combination of topical application of imiquimod 5% followed by CO2 laser ablation has been reported for the treatment of anal and perianal GCAs. 26 Oral retinoids acting as cellular modifying agents have been tried in a few cases.…”

Section: Discussionmentioning

confidence: 99%

Radical Excision and Mesh-Skin Grafting for Giant Anorectal Condyloma Acuminatum

Chaidemenos

KOGIA

Souparis

et al. 2006

Dermatologic Surgery

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BACKGROUND Giant Condyloma Acuminatum (GCA) presents difficulties in therapeutic management, mainly due to local invasion and recurrences. Treatment measures vary from topical agents to aggressive methods such as surgical excision, radiation, laser surgery, chemotherapy, immunotherapy or their combination. METHOD A 48-year-old heterosexual, HIV-negative male with a 20 year-year history of GCA, following an unsuccessful surgical operation, underwent radical excision with immediate mesh-skin grafting. CONCLUSION The absence of relapse and the excellent cosmetic results obtained one and a half years post-operative may put this treatment option in the first line of treatment choices for GCA

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Condylomata gigantea in anal and perianal region: surgical and CO2 laser treatment

Cited by 24 publications

References 6 publications

HPV Carcinomas in Immunocompromised Patients

HPV Carcinomas in Immunocompromised Patients

Holmium:YAG Laser for the Treatment of Genital and urethral Warts: Multicentre Prospective Evaluation of Safety and Efficacy

Radical Excision and Mesh-Skin Grafting for Giant Anorectal Condyloma Acuminatum

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