Conductometric Determination of Losartan Potassium Using Phosphotungstic Acid, Bromocresol Purple, Mercury (Ii) Chloride, and Cupric Chloride as Reagents

Abstract

Objectives: In the current study a simple and precise four conductometric methods were introduced for determination of Losartan Potassium (LK) in pure form and tablets.
 Methods: Method A is based on titration of LK using phosphotungstic acid, method B is based on titration of LK using bromocresol purple dye, method C is based on titration of LK using mercury (II) chloride, and method D is based on titration of LK using cupric chloride.
 Results: LK was found to be linear in the concentration range of 3–20 mg/mL for all methods except for method C, the concentration range was 1–12 mg/mL. The obtained percentage recoveries for the four methods ranged from 99.69% to 100.53%; the relative standard deviation values were not exceeding two for all methods.
 Conclusion: The suggested methods were successfully applied for the determination of LK in tablets, with results in close agreement at 95% confidence level with those obtained using the reference spectrophotometric method.