Conductivity of single-stranded and double-stranded deoxyribose nucleic acid under ambient conditions: The dominance of water

Kleine‐Ostmann, Thomas; Jördens, C.; Baaske, Kai; Weimann, Thomas; Angelis, Martin Hrabě de; Koch, Martin

doi:10.1063/1.2182027

Cited by 56 publications

(94 citation statements)

References 21 publications

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“…Exponential increases in conductance values with increases in relative humidity (RH) for poly(GC) and poly(AT) DNAs have been reported, with a ∼10 6 difference in conductance values observed between 5 and 90% RH. The humidity-dependent conductivity and negligible changes between ds-and singlestranded DNA were speculated to be due to ionic conduction in the water layer within the bulk film [47]. Our measurements are performed through well defined device structures with the electrode-electrode separation distances comparable with the length of the 15-bp ds-DNA.…”

Section: Resultsmentioning

confidence: 99%

“…The effect of humidity on DNA conductance has been previously studied by various groups [47][48][49][50], generally through measurements performed with relatively thick layers of much longer DNAs and using device structures that provide an electrode-electrode separation distance much larger than the length of a single oligonucleotide. In this regime, the overall conductance is dominated by molecule-to-molecule transfer (probably hopping or ion-mediated transport).…”

Section: Resultsmentioning

confidence: 99%

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Sequence specific electronic conduction through polyion-stabilized double-stranded DNA in nanoscale break junctions

Mahapatro¹,

Jeong²,

G³

et al. 2007

Nanotechnology

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This paper presents a study of sequence specific electronic conduction through short (15-base-pair) double-stranded (ds) DNA molecules, measured by immobilizing 3 -thiol-derivatized DNAs in nanometre scale gaps between gold electrodes. The polycation spermidine was used to stabilize the ds-DNA structure, allowing electrical measurements to be performed in a dry state. For specific sequences, the conductivity was observed to scale with the surface density of immobilized DNA, which can be controlled by the buffer concentration. A series of 15-base DNA oligonucleotide pairs, in which the centre sequence of five base pairs was changed from G:C to A:T pairs, has been studied. The conductivity per molecule is observed to decrease exponentially with the number of adjacent A:T pairs replacing G:C pairs, consistent with a barrier at the A:T sites. Conductance-based devices for short DNA sequences could provide sensing approaches with direct electrical readout, as well as label-free detection.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Sequence specific electronic conduction through polyion-stabilized double-stranded DNA in nanoscale break junctions

Mahapatro¹,

Jeong²,

G³

et al. 2007

Nanotechnology

View full text Add to dashboard Cite

show abstract

“…The result is a smaller self-energy and a larger resulting conductivity. Surprisingly, experiments on individual DNA molecules [9], DNA films [10,11,12,13], and DNA bundles [7,8] all show a similar exponential dependence of conductivity on humidity. The lack of a geometry-dependent difference remains a puzzle.…”

Section: Discussionmentioning

confidence: 99%

Ionic conductivity on a wetting surface

2009

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Recent experiments measuring the electrical conductivity of DNA molecules highlight the need for a theoretical model of ion transport along a charged surface. Here we present a simple theory based on the idea of unbinding of ion pairs. The strong humidity dependence of conductivity is explained by the decrease in the electrostatic self-energy of a separated pair when a layer of water (with high dielectric constant) is adsorbed to the surface. We compare our prediction for conductivity to experiment, and discuss the limits of its applicability.

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“…36,37 Hydrophilic phosphoric acid chains control the number of water molecules adsorbed on the DNA fragments, as suggested by Otsuka et al 36 and Ha et al 37 Also, the effect of environment on the DNA fragments after drying cannot be ignored. 38,39 Under high humidity levels, water molecules will further accumulate on the phosphate backbone of DNA fragments. 39 Electrical measurements in this paper are conducted in a laboratory facility with daily average humidity levels between 30% and 45%.…”

Section: Scheme 1 Schematic Diagram Of Template Growth Ofmentioning

confidence: 99%

“…38,39 Under high humidity levels, water molecules will further accumulate on the phosphate backbone of DNA fragments. 39 Electrical measurements in this paper are conducted in a laboratory facility with daily average humidity levels between 30% and 45%. Therefore, ssDNA(II) fragments bear negative charges with water molecules surrounding them.…”

Section: Scheme 1 Schematic Diagram Of Template Growth Ofmentioning

confidence: 99%

Multisegment Nanowire Sensors for the Detection of DNA Molecules

2008

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We describe a novel application for detecting specific single strand DNA sequences using multisegment nanowires via a straightforward surface functionalization method. Nanowires comprising CdTe−Au−CdTe segments are fabricated using electrochemical deposition, and electrical characterization indicates a p-type behavior for the multisegment nanostructures, in a back-to-back Schottky diode configuration. Such nanostructures modified with thiol-terminated probe DNA fragments could function as high fidelity sensors for biomolecules at very low concentration. The gold segment is utilized for functionalization and binding of single strand DNA (ssDNA) fragments while the CdTe segments at both ends serve to modulate the equilibrium Fermi level of the heterojunction device upon hybridization of the complementary DNA fragments (cDNA) to the ssDNA over the Au segment. Employing such multisegment nanowires could lead to the fabrication more sophisticated and high multispecificity biosensors via selective functionalization of individual segments for biowarfare sensing and medical diagnostics applications.Nanowire-based field-effect transistors (FET) have been widely used for detection of a variety of biological and chemical species, detection of PH value, detection of metal ions, viruses, proteins, etc. [1][2][3][4] In most of these applications, the mechanism of sensing is based on the functionalization of a homogeneous semiconducting nanowire, such as silicon 4 and In 2 O 3 nanowires. 5 There is a growing interest in fabricating heterojunction nanowires, which show great potential for applications in nanoelectronics, 6 energy conversion, 7 self-assembly, 8 and controlled positioning of nanowire arrays. 9 Generally, there are two basic morphologies in nanowire heterostructures: radial heterostructures, such as core-shell nanowires, and axial heterostructures, comprising multisegment nanowires. Core-shell nanowires have been used to fabricate coaxially gated nanowire transistors. 10,11 Multisegment nanowires comprise several different material compositions or phases along its length, and their synthesis have been demonstrated in a variety of configurations including the growth of nanowire superlattices via alternating laser ablation of different solid targets. The superlattices inside the nanowires make them engineered materials having a high thermoelectric coefficient, 12 possible uses in p-n junction diodes, 13 and with notable optical properties via photoluminescence characterization. 14 Electrochemical template synthesis is a versatile technique for producing multisegment nanowires, in which individual segments could be metallic, oxide, binary, or ternary alloys and semiconducting and conducting polymers. And specific functionality including optical, magnetic, or electrical properties could be introduced. Multisegment metallic nanowires synthesized by electrochemistry have been assembled endto-end by using different linkages, such as biomolecules [15][16][17][18] and polymers. 19 Nanowires capped with magnetic met...

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Conductivity of single-stranded and double-stranded deoxyribose nucleic acid under ambient conditions: The dominance of water

Cited by 56 publications

References 21 publications

Sequence specific electronic conduction through polyion-stabilized double-stranded DNA in nanoscale break junctions

Sequence specific electronic conduction through polyion-stabilized double-stranded DNA in nanoscale break junctions

Ionic conductivity on a wetting surface

Multisegment Nanowire Sensors for the Detection of DNA Molecules

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