Conductive Tough Hydrogel for Bioapplications

Javadi, Mohammad Sadegh; Gu, Qi; Naficy, Sina; Farajikhah, Syamak; Crook, Jeremy Micah; Wallace, Gordon G.; Beirne, Stephen; Moulton, Simon E.

doi:10.1002/mabi.201700270

Cited by 55 publications

(48 citation statements)

References 51 publications

(59 reference statements)

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“…Expanding beyond rat models to human neuronal stem cells, Javadi et al produced a highly conductive polyurethane hydrogel doped with 1:1 PEDOT:PSS/liquid‐crystal graphene oxide thus named polyurethane hybrid composite (PUHC). At 8 wt% doping, conductivity reaches an astounding 12 S cm −1 ; higher doping percentages were accompanied by unfavorable increases in stiffness.…”

Section: Conductive Scaffolds For Neuronal Tissue Engineeringmentioning

confidence: 99%

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Burnstine‐Townley

Eshel

Amdursky

2019

Adv Funct Materials

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Tissue engineering is a promising therapeutic approach in medicine, targeting the replacement of a diseased tissue with a healthy one grown within an artificial scaffold. Due to the high prevalence of cardiac and brain‐related ailments that involve some necrosis of tissue, cardiac and neuronal tissue engineering are intensely studied fields in regenerative medicine. A growing trend in the use of conductive scaffolds for the growth of these tissues has been witnessed recently. While the results are irrefutable, the mechanism of how an electrically conducting scaffold interacts with an electroactive tissue remains has remained elusive. An up‐to‐date summary of all work done in the field is reported, with a special focus on the specific contribution of the conductive scaffold on the performance of the formed tissue. The cell–scaffold electronic interface is then explored from an electrical engineering perspective. The electronic configuration of the system and the mechanisms and governing factors controlling the ability of a conductive scaffold to support cardiac and neuronal tissues are discussed. Using several simulations, the required conductivity of the scaffold in order for it to be suitable for tissue engineering—which also depends on the nature of the charge carriers—is also discussed.

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Section: Conductive Scaffolds For Neuronal Tissue Engineeringmentioning

confidence: 99%

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Burnstine‐Townley

Eshel

Amdursky

2019

Adv Funct Materials

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“…Recently, a conductive and biocompatible hydrogel combined with a polyurethane matrix, PEDOT:PSS, and liquid crystal graphene oxide was fabricated to facilitate electrical stimulation during 3D culture of human neural stem cells. Not only was high viability achieved with this type of hybrid scaffold, but electrical stimulation during culture was shown to enhance neuritogenesis [64]. An intimate mix of a conducting polymer with a hydrogel can be achieved as follows.…”

Section: Organic Semiconductors For Bioelectronic Applicationmentioning

confidence: 99%

Organic Bioelectronics: Materials and Biocompatibility

Feron

Lim

Sherwood

et al. 2018

IJMS

113

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Organic electronic materials have been considered for a wide-range of technological applications. More recently these organic (semi)conductors (encompassing both conducting and semi-conducting organic electronic materials) have received increasing attention as materials for bioelectronic applications. Biological tissues typically comprise soft, elastic, carbon-based macromolecules and polymers, and communication in these biological systems is usually mediated via mixed electronic and ionic conduction. In contrast to hard inorganic semiconductors, whose primary charge carriers are electrons and holes, organic (semi)conductors uniquely match the mechanical and conduction properties of biotic tissue. Here, we review the biocompatibility of organic electronic materials and their implementation in bioelectronic applications.

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“…In neural tissue engineering, research has shown the necessity of producing conductive hydrogels that can easily change conductivity corresponding to the different electrical environments of nerve tissues. Xu et al synthesized a conducting complex nerve conduit with PPy and poly (d, l-lactic acid) and evaluated its capability to carry the differentiation of rat pheochromocytoma 12 (PC 12) cells in vitro, which determined the ability to encourage nerve regeneration in vivo [170]. Depending on the PPy content of the produced nerve conduit, the conductivity was in the range of 15.56 ms·cm -1 to 5.65 ms·cm -1 .…”

Section: Nerve Tissue Engineeringmentioning

confidence: 99%

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

Min¹,

Koh²

2018

Preprint

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In the field of tissue engineering, conductive hydrogels have been the most effective biomaterials to mimic the biological and electrical properties of tissues in the human body. The main advantages of conductive hydrogel include not only its physical properties, but also its adequate electrical properties, thus providing electrical signals to cells efficiently. However, when introducing a conductive material into a non-conductive hydrogel, a conflicting relationship between the electrical and mechanical properties may develop. This review examines the strengths and weaknesses of the generation of conductive hydrogels using various conductive materials and introduces the use of these conductive hydrogels in tissue engineering applications.

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Conductive Tough Hydrogel for Bioapplications

Cited by 55 publications

References 51 publications

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Organic Bioelectronics: Materials and Biocompatibility

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

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