Conductive nanostructured materials based on poly-(3,4-ethylenedioxythiophene) (PEDOT) and starch/κ-carrageenan for biomedical applications

Zamora‐Sequeira, Roy; Ardao, Inés; Starbird, Ricardo; García‐González, Carlos A.

doi:10.1016/j.carbpol.2018.02.040

Cited by 54 publications

(43 citation statements)

References 50 publications

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“…All the tested starch aerogel formulations had a volume reduction (shrinkage) after the serial water-to-ethanol solvent exchanges and the supercritical drying steps with respect to the initial volume of the gel dispersions (ΔV in Table 1). The volume reduction observed for the starch aerogel formulation [Z0] (39.1% in Table 1) was a similar value to those reported by other authors [33,35,36]. The gel shrinkage was reported to mainly occur during the solvent exchange step and to decrease with the starch content of the formulation [33].…”

Section: Resultssupporting

confidence: 85%

Sterile and Dual-Porous Aerogels Scaffolds Obtained through a Multistep Supercritical CO2-Based Approach

et al. 2019

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Aerogels from natural polymers are endowed with attractive textural and biological properties for biomedical applications due to their high open mesoporosity, low density, and reduced toxicity. Nevertheless, the lack of macroporosity in the aerogel structure and of a sterilization method suitable for these materials restrict their use for regenerative medicine purposes and prompt the research on getting ready-to-implant dual (macro + meso)porous aerogels. In this work, zein, a family of proteins present in materials for tissue engineering, was evaluated as a sacrificial porogen to obtain macroporous starch aerogels. This approach was particularly advantageous since it could be integrated in the conventional aerogel processing method without extra leaching steps. Physicochemical, morphological, and mechanical characterization were performed to study the effect of porogen zein at various proportions (0:1, 1:2, and 1:1 zein:starch weight ratio) on the properties of the obtained starch-based aerogels. From a forward-looking perspective for its clinical application, a supercritical CO2 sterilization treatment was implemented for these aerogels. The sterilization efficacy and the influence of the treatment on the aerogel final properties were evaluated mainly in terms of absence of microbial growth, cytocompatibility, as well as physicochemical, structural, and mechanical modifications.

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Section: Resultssupporting

confidence: 85%

Sterile and Dual-Porous Aerogels Scaffolds Obtained through a Multistep Supercritical CO2-Based Approach

et al. 2019

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“…By adjusting the processing methods, starch aerogels can be made in the shape of monoliths [36] or as particles, the latter usually via emulsion-gelation techniques [44,365]. Composite starch aerogels can be prepared by mixing starch solution with other components [366].…”

Section: Aerogels From Starchmentioning

confidence: 99%

“…After heating at 500 °C in air for 5 h, starch was burned, and the remaining TiO2 network was a fine replica of the structures of the starch-based aerogels [380]. Starch based aerogels can also be used as a template to form conductive porous materials, such as poly(3,4-ethylenedioxythiophene) (PEDOT) networks for biomedical applications [366,381].…”

Section: Aerogels From Starchmentioning

confidence: 99%

Biorefinery Approach for Aerogels

et al. 2020

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According to the International Energy Agency, biorefinery is “the sustainable processing of biomass into a spectrum of marketable bio-based products (chemicals, materials) and bioenergy (fuels, power, heat)”. In this review, we survey how the biorefinery approach can be applied to highly porous and nanostructured materials, namely aerogels. Historically, aerogels were first developed using inorganic matter. Subsequently, synthetic polymers were also employed. At the beginning of the 21st century, new aerogels were created based on biomass. Which sources of biomass can be used to make aerogels and how? This review answers these questions, paying special attention to bio-aerogels’ environmental and biomedical applications. The article is a result of fruitful exchanges in the frame of the European project COST Action “CA 18125 AERoGELS: Advanced Engineering and Research of aeroGels for Environment and Life Sciences”.

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“…According to the previous work, the electrochemical properties of PEDOT are retained when κC is used as a doping agent [29,30], avoiding a potential delamination during the reduction-oxidation process needed during the active delivering process. Biocompatibility of PEDOT:κC composite has been demonstrated in previous studies [2,29].…”

Section: Introductionmentioning

confidence: 98%

“…κ-Carrageenan (κC) is a sulfonated polysaccharide recently used in aqueous micellar dispersions for the polymerization of EDOT, since it provides an appropriate environment for the monomer dispersion while acting as a doping agent in the conductive layer [29][30][31]. According to the previous work, the electrochemical properties of PEDOT are retained when κC is used as a doping agent [29,30], avoiding a potential delamination during the reduction-oxidation process needed during the active delivering process. Biocompatibility of PEDOT:κC composite has been demonstrated in previous studies [2,29].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide κ-Carrageenan as Doping Agent in Conductive Coatings for Electrochemical Controlled Release of Dexamethasone at Therapeutic Doses

et al. 2020

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Smart conductive materials are developed in regenerative medicine to promote a controlled release profile of charged bioactive agents in the vicinity of implants. The incorporation and the active electrochemical release of the charged compounds into the organic conductive coating is achieved due to its intrinsic electrical properties. The anti-inflammatory drug dexamethasone was added during the polymerization, and its subsequent release at therapeutic doses was reached by electrical stimulation. In this work, a Poly (3,4-ethylenedioxythiophene): κ-carrageenan: dexamethasone film was prepared, and κ-carrageenan was incorporated to keep the electrochemical and physical stability of the electroactive matrix. The presence of κ-carrageenan and dexamethasone in the conductive film was confirmed by µ-Raman spectroscopy and their effect in the topographic was studied using profilometry. The dexamethasone release process was evaluated by cyclic voltammetry and High-Resolution mass spectrometry. In conclusion, κ-carrageenan as a doping agent improves the electrical properties of the conductive layer allowing the release of dexamethasone at therapeutic levels by electrochemical stimulation, providing a stable system to be used in organic bioelectronics systems.

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Conductive nanostructured materials based on poly-(3,4-ethylenedioxythiophene) (PEDOT) and starch/κ-carrageenan for biomedical applications

Cited by 54 publications

References 50 publications

Sterile and Dual-Porous Aerogels Scaffolds Obtained through a Multistep Supercritical CO2-Based Approach

Sterile and Dual-Porous Aerogels Scaffolds Obtained through a Multistep Supercritical CO2-Based Approach

Biorefinery Approach for Aerogels

Polysaccharide κ-Carrageenan as Doping Agent in Conductive Coatings for Electrochemical Controlled Release of Dexamethasone at Therapeutic Doses

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