Conductive Nanofiber Scaffold for Bone Tissue Engineering

Boroojeni, Fatemeh Rasti; Mashayekhan, Shohreh; Abbaszadeh, Hojjat-Allah; Ansarizadeh, Mohamadhasan

doi:10.1109/icbme.2017.8430283

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…This is partly due to the ease of scaffold creation and the ECM like mat structure that is formed through this process [ 184 ]. Studies have shown that nanofiber scaffolds containing conductive nanoparticles made of PANI and graphene were able to increase cell viability with increased amounts (up to 2% in PCL) [ 185 ]. Suggesting that different cellular functions could be improved through conductive nanomaterial incorporation, although there are limitations.…”

Section: Conductive Materials and Strategies For Induced Bone Regenerationmentioning

confidence: 99%

Conductive Scaffolds for Bone Tissue Engineering: Current State and Future Outlook

Dixon

Gomillion

2021

JFB

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Bone tissue engineering strategies attempt to regenerate bone tissue lost due to injury or disease. Three-dimensional (3D) scaffolds maintain structural integrity and provide support, while improving tissue regeneration through amplified cellular responses between implanted materials and native tissues. Through this, scaffolds that show great osteoinductive abilities as well as desirable mechanical properties have been studied. Recently, scaffolding for engineered bone-like tissues have evolved with the use of conductive materials for increased scaffold bioactivity. These materials make use of several characteristics that have been shown to be useful in tissue engineering applications and combine them in the hope of improved cellular responses through stimulation (i.e., mechanical or electrical). With the addition of conductive materials, these bioactive synthetic bone substitutes could result in improved regeneration outcomes by reducing current factors limiting the effectiveness of existing scaffolding materials. This review seeks to overview the challenges associated with the current state of bone tissue engineering, the need to produce new grafting substitutes, and the promising future that conductive materials present towards alleviating the issues associated with bone repair and regeneration.

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Section: Conductive Materials and Strategies For Induced Bone Regenerationmentioning

confidence: 99%

Conductive Scaffolds for Bone Tissue Engineering: Current State and Future Outlook

Dixon

Gomillion

2021

JFB

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“…Graphene showed an important versatility since it was employed as filler in different base materials like chitosan/gelatin matrices, hydrogels and Poly(trimethylene carbonate) (PTMC). Biological properties like better adhesion, spreading and proliferation of cells on the conductive graphene make it a suitable material for scaffold based applications in tissue engineering [85][86][87][88][89][90][91].…”

mentioning

confidence: 99%

A Review on Biomaterials for 3D Conductive Scaffolds for Stimulating and Monitoring Cellular Activities

et al. 2019

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During the last years, scientific research in biotechnology has been reporting a considerable boost forward due to many advances marked in different technological areas. Researchers working in the field of regenerative medicine, mechanobiology and pharmacology have been constantly looking for non-invasive methods able to track tissue development, monitor biological processes and check effectiveness in treatments. The possibility to control cell cultures and quantify their products represents indeed one of the most promising and exciting hurdles. In this perspective, the use of conductive materials able to map cell activity in a three-dimensional environment represents the most interesting approach. The greatest potential of this strategy relies on the possibility to correlate measurable changes in electrical parameters with specific cell cycle events, without affecting their maturation process and considering a physiological-like setting. Up to now, several conductive materials has been identified and validated as possible solutions in scaffold development, but still few works have stressed the possibility to use conductive scaffolds for non-invasive electrical cell monitoring. In this picture, the main objective of this review was to define the state-of-the-art concerning conductive biomaterials to provide researchers with practical guidelines for developing specific applications addressing cell growth and differentiation monitoring. Therefore, a comprehensive review of all the available conductive biomaterials (polymers, carbon-based, and metals) was given in terms of their main electric characteristics and range of applications.

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Conductive Nanofiber Scaffold for Bone Tissue Engineering

Cited by 2 publications

References 18 publications

Conductive Scaffolds for Bone Tissue Engineering: Current State and Future Outlook

Conductive Scaffolds for Bone Tissue Engineering: Current State and Future Outlook

A Review on Biomaterials for 3D Conductive Scaffolds for Stimulating and Monitoring Cellular Activities

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