Conductive Hearing Loss in Patients with Active Acromegaly

Babić, Borivoj; Petakov, Мilan; Djukić, Vojko; Ognjanović, Sanja; Arsović, Nenad; Isailovic, Tatjana; Milovanovic, Jovica D.; Macut, Djuro; Damjanović, Svetozar

doi:10.1097/01.mao.0000201429.57746.1b

Cited by 10 publications

(9 citation statements)

References 5 publications

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“…In contrast to a recent report by Babic et al. , 5 we did not observe a relationship between disease duration and hearing loss.…”

Section: Discussioncontrasting

confidence: 99%

“…The mean PTA in patients with acromegaly was higher than that in controls; however, PTA did not differ significantly between the three patient groups, indicating that acromegaly might cause hearing loss and that disease activity has no effect. In contrast to a recent report by Babic et al, 5 we did not observe a relationship between disease duration and hearing loss. Previous studies have primarily investigated conductive-type hearing loss in patients with acromegaly.…”

Section: Discussioncontrasting

confidence: 99%

“…More recently, Babic et al. 5 analysed conductive hearing loss in patients with active acromegaly and reported that the incidence of abnormal middle ear ventilation was higher in patients than in the control population.…”

Section: Introductionmentioning

confidence: 99%

“…3 Doig and Gatehouse performed pure tone audiometry (PTA) in patients with acromegaly to assess air and bone conduction and reported no changes in hearing function. 4 More recently, Babic et al 5 analysed conductive hearing loss in patients with active acromegaly and reported that the incidence of abnormal middle ear ventilation was higher in patients than in the control population.…”

Section: Introductionmentioning

confidence: 99%

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Functional and structural evaluation of hearing in acromegaly

Aydín

Öztürk²,

Türkyılmaz³

et al. 2012

Clinical Endocrinology

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Summary Context The impact of acromegaly on the auditory system remains unknown. Objective This study aimed to examine audiological symptoms and the structure and function of the auditory system in patients with acromegaly. Design/Setting and Patients The study included 44 patients with acromegaly. Pure tone audiometry, speech audiometry, tympanometry, otoacoustic emissions testing, computerized tomography of the temporal bone and magnetic resonance imaging of the ear were performed in all patients. The study also included 36 age‐ and sex‐matched healthy controls. The patients with acromegaly were divided into three subgroups, as follows: controlled disease (n = 13); partially controlled disease (n = 16); uncontrolled disease (n = 15). Results In all, 43% of the patients with acromegaly had hearing loss, and 20% had had an episode of otitis in at least one ear. Median pure tone average (PTA) in the patients with acromegaly was 12.5 dB (range: 2–72 dB), vs 8.3 dB (range: 0–20 dB) in the control group (P < 0.001). PTA did not differ significantly between the three patient subgroups. Audiometric tests showed various degrees of hearing loss in at least one ear in 21 patients (48%). Conductive, sensorineural and mixed type hearing loss in at least one ear was noted in 9%, 30% and 18% of the patients, respectively. Auditory imaging showed that 50% of the patients had temporomandibular joint degeneration (TMJD). Conclusions Hearing loss is quite common in patients with acromegaly. Contrary to common belief, in this study, conductive hearing loss did not occur more frequently than other types. Based on PTA findings in the controls and patients with acromegaly, acromegaly caused hearing loss, but the level of disease activity had no effect on hearing. Middle ear pressure problems might be caused by increased perilymph because of growth hormone (GH)‐related volume overload.

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“…In contrast to a recent report by Babic et al. , 5 we did not observe a relationship between disease duration and hearing loss.…”

Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Functional and structural evaluation of hearing in acromegaly

Aydín

Öztürk²,

Türkyılmaz³

et al. 2012

Clinical Endocrinology

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show abstract

“…Babic et al 12 assessed a group of 30 untreated acromegalic patients, compared to a group of 20 patients in searching for evidence of conductive hearing loss. There was a higher prevalence of middle ear ventilation problems in acromegalic patients, seven (23%), compared to none in the control group, p = 0.033.…”

Section: Introductionmentioning

confidence: 99%

Perda auditiva sensorioneural em pacientes com acromegalia em tratamento

Carvalho

Júnior

Freitas

et al. 2012

Braz. j. otorhinolaryngol.

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Acromegal y is a rare endocrine disease. Few studies have evaluated its association with hearing loss (HL) and the results are conflicting. Aim:To evaluate the prevalence and features of HL in a group of patients being treated for acromegaly. To analyze peripheral and central auditory transmission.Methods: Cross-sectional study. A group of 34 patients with acromegaly were submitted to metabolic evaluation, tonal audiometry and brainstem auditory evoked potentials. HL was considered when pure tone average was > 25 DBHL for low frequencies (250, 500, 1000 and 2000 Hz) or high frequencies (3000, 4000, 6000 and 8000 Hz). The patients were divided in group A (with HL) and B (without HL).Results: Twelve patients (35.3%) had sensorineural HL (Group A), being 8 bilateral and 4 unilateral. No one had mixed or conductive HL. The prevalence of diabetes/impaired glucose tolerance was similar between the groups. The frequencies 3000, 4000, 6000 and 8000 Hz were the most affected and with a similar pattern in both ears. Conclusion:sensorineural HL was found in 38.9% of cases. Neither clinical nor metabolic differences were noted between the groups, as well as in regards to peripheral and central auditory transmission. Braz J Otorhinolaryngol. 2012;78(4):98-102. ORIGINAL ARTICLE BJORL

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Challenges in the diagnosis and management of acromegaly: a focus on comorbidities

et al. 2016

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IntroductionAcromegaly is a rare, insidious disease resulting from the overproduction of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), and is associated with a range of comorbidities. The extent of associated complications and mortality risk is related to length of exposure to the excess GH and IGF-1, thus early diagnosis and treatment is imperative. Unfortunately, acromegaly is often diagnosed late, when patients already have a wide range of comorbidities. The presence of comorbid conditions contributes significantly to patient morbidity/mortality and impaired quality of life.MethodsWe conducted a retrospective literature review for information relating to the diagnosis of acromegaly, and its associated comorbidities using PubMed. The main aim of this review is to highlight the issues of comorbidities in acromegaly, and to reinforce the importance of early diagnosis and treatment.Findings and conclusionsSuccessful management of acromegaly goes beyond treating the disease itself, since many patients are diagnosed late in disease evolution, they present with a range of comorbid conditions, such as cardiovascular disease, diabetes, hypertension, and sleep apnea. It is important that patients are screened carefully at diagnosis (and thereafter), for common associated complications, and that biochemical control does not become the only treatment goal. Mortality and morbidities in acromegaly can be reduced successfully if patients are treated using a multimodal approach with comprehensive comorbidity management.

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Conductive Hearing Loss in Patients with Active Acromegaly

Abstract: Patients with active acromegaly have more frequent middle ear ventilation problem than normal population, especially those with longer duration of the disease. Possible causes are discussed.

Cited by 10 publications

References 5 publications

Functional and structural evaluation of hearing in acromegaly

Functional and structural evaluation of hearing in acromegaly

Perda auditiva sensorioneural em pacientes com acromegalia em tratamento

Challenges in the diagnosis and management of acromegaly: a focus on comorbidities

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