Conduction Dysfunction and Near Expunction: Giant Cell Myocarditis

Gleber, Conrad; Yoruk, Ayhan; Eastburg, Luke; Goldman, Bruce; Cameron, Scott J.

doi:10.1016/j.amjmed.2018.04.011

Cited by 2 publications

(2 citation statements)

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“…Classic reports of GCM include patients with acute onset heart failure rapidly progressing to cardiogenic shock and death within weeks to months of initial presentation. 4,[6][7][8] GCM is often associated with refractory ventricular arrhythmias or other conduction abnormalities. 4,7,9,10 Only 14-29% of patients initially present with VT compared with more than 75% of patients presenting with acutely decompensated heart failure.…”

Section: Discussionmentioning

confidence: 99%

“…4,[6][7][8] GCM is often associated with refractory ventricular arrhythmias or other conduction abnormalities. 4,7,9,10 Only 14-29% of patients initially present with VT compared with more than 75% of patients presenting with acutely decompensated heart failure. 1 These figures are likely a reflection of historical findings when GCM was only identified at the time of autopsy.…”

Section: Discussionmentioning

confidence: 99%

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A giant mystery in giant cell myocarditis: navigating diagnosis, immunosuppression, and mechanical circulatory support

et al. 2019

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Giant cell myocarditis is a rare but often devastating diagnosis. Advances in cardiac imaging and mechanical circulatory support have led to earlier and more frequent diagnoses and successful management. This disease state has wide variation in acuity of presentation, and consequently, optimal treatment ranging from intensity and type of immunosuppression to mechanical circulatory support is not well defined. The following case describes the management of a patient with an unusual presentation of giant cell myocarditis over a 10 year course of advanced heart failure therapies and immunomodulatory support. This case highlights emerging concepts in the management of giant cell myocarditis including sub‐acute presentations, challenges in diagnosis, and treatment modalities in the modern era.

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