Conducting Polymer Based Nanobiosensors

Park, Chul Soon; Lee, Changsoo; Kwon, Oh Seok

doi:10.3390/polym8070249

Cited by 112 publications

(56 citation statements)

References 70 publications

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“…Conducting polymers have also been applied towards the development of biosensing platforms taking advantage of their high surface area, small dimensions, inherent electrical conductivity and unique physical properties, while also having potential applicability in flexible/wearable electronics in which conducting polymers can display a flexible organic conductor or semiconductor behavior [35,104,105]. In this way, Qin et al [103] developed a biosensor for monitoring early diagnosis of AD through Aβ oligomers determination based on the electrically conducting poly(pyrrole-2-carboxylic acid) (PPy) and using PrP c as the biological recognition element.…”

Section: Polymer Nanomaterialsmentioning

confidence: 99%

Nanomaterials towards Biosensing of Alzheimer’s Disease Biomarkers

2019

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Alzheimer’s disease (AD) is an incurable and highly debilitating condition characterized by the progressive degeneration and/or death of nerve cells, which leads to manifestation of disabilities in cognitive functioning. In recent years, the development of biosensors for determination of AD’s main biomarkers has made remarkable progress, particularly based on the tremendous advances in nanoscience and nanotechnology. The unique and outstanding properties of nanomaterials (such as graphene, carbon nanotubes, gold, silver and magnetic nanoparticles, polymers and quantum dots) have been contributing to enhance the electrochemical and optical behavior of transducers while offering a suitable matrix for the immobilization of biological recognition elements. Therefore, optical and electrochemical immuno- and DNA-biosensors with higher sensitivity, selectivity and longer stability have been reported. Nevertheless, strategies based on the detection of multiple analytes still need to be improved, as they will play a crucial role in minimizing misdiagnosis. This review aims to provide insights into the conjugation of nanomaterials with different transducers highlighting their crucial role in the construction of biosensors for detection of AD main biomarkers.

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Section: Polymer Nanomaterialsmentioning

confidence: 99%

Nanomaterials towards Biosensing of Alzheimer’s Disease Biomarkers

2019

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“…PANI is electroconductive and electrochemically active polymer that has found increasing attention in biosensor assembly due to reversibility of redox response and effective electric wiring of the binding sites of biomolecules with electrode [30][31][32]. In DNA sensors, PANI is employed as an anchor for physical immobilization of negatively charged DNA oligonucleotides and as enhancer of redox label [33].…”

Section: Aptasensor Assemblingmentioning

confidence: 99%

Electrochemical Aptasensor with Layer‐by‐layer Deposited Polyaniline for Aflatoxin M1 Voltammetric Determination

et al. 2019

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Mycotoxins are highly toxic metabolites of some fungi that frequently contaminate water, food and feed and hence cause several human and animal diseases. In this work, a new approach to the fast and reliable determination of aflatoxin M1 (AFM1) in water and milk has been proposed with reagent free protocol of signal measurement. For this purpose, DNA aptamer selective to AFM1 was entrapped between two thin layers of polyaniline (PANI) electrodeposited on glassy carbon electrode. The incubation of the aptasensor in the AFM1 solution results in remarkable decrease of the PANI intrinsic activity monitored by direct current voltammetry or electrochemical impedance spectroscopy. Appropriate calibration curves were linear in the range from 3 to 90 ng/L with limit of detection (LOD) 1–5 ng/L depending on the measurement mode. Mechanism of signal generation involves shielding electrostatic interactions between the PANI and aptamer in the surface layer and variation of its redox activity attributed to the emeraldine form of PANI. Selectivity of the response was proved by similar experiments with aflatoxin B1 and ochratoxin A and by comparison of the results with those obtained with non‐specific aptamer in the sensing layer. Simple protocol for milk pretreatment has been proposed for reliable detection of AFM1 on the level of its threshold limited values (20 ng/L).

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“…8 In hyperthermia treatment, biocompatible conductive polymers have photothermal convertible efficiencies and photostability that would be higher than commercially available inorganic-based photothermal ablation agents. 9 Polypyrrole (Ppy) functions as one potential organic conductive polymeric material and is extensively applied for organic electronic use due to its excellent stability, conductivity, and great absorbance in the near-infrared (NIR) range. 10 Ppy is tremendously useful for various biological applications.…”

Section: Introductionmentioning

confidence: 99%

<p>Biofunctional core-shell polypyrrole–polyethylenimine nanocomplex for a locally sustained photothermal with reactive oxygen species enhanced therapeutic effect against lung cancer</p>

Chiang¹,

Chuang²

2019

IJN

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Background: Polymeric delivery systems have been elucidated over the last few years as an approach of achieving high therapeutic effect to the local site of malignant disease patients who have cancer. Polypyrrole (Ppy) is a potential organic conducting polymer which has long been recognized as a versatile material due to its excellent stability, conductive properties, and great absorbance in the range of near-infrared (NIR). It is tremendously versatile for use in various biomedical fields such as cancer therapy. NIR irradiation-activated treatment platform technologies are now being considered to be novel and exciting options in potential nanomedicine. However, the realistic photothermal use of Ppy-applied nanomaterials is yet in its early phase, and there are a few disadvantages of Ppy, such as its water insolubility. In the clinic, the common approach for treatment of lung cancer is the delivery of therapeutic active substances through intratumoral administration. Nevertheless, the tumor uptake, regional retention, mechanism of treatment, and tissue organ penetration regarding the developed strategy of this nanomaterial with photothermal hyperthermia are important issues for exerting effective cancer therapy. Materials and methods: In this study, we developed a cationic Ppy-polyethylenimine nanocomplex (NC) with photothermal hyperthermia to study its physicochemical characteristics, including size distribution, zeta potential, and transmission electron microscopy, scanning electron microscopy, and Fourier transform infrared morphology. We also examined the cellular uptake effect on lung cancer cells, the photothermal properties, intracellularly generated reactive oxygen species (ROS), and cytotoxicity. Results: The results suggested that this nanocarrier system was able to effectively attach onto lung cancer cells for subsequent endocytosis. The NCs taken up were able to absorb NIR and then converted the NIR light into local hyperthermia with its intracellular photothermal performance to provide local hyperthermic treatment. This regionally generated hyperthermia also induced ROS formation and improved the killing of lung cancer cells as a promising local photothermal therapy. Conclusion: This development of a nanocarrier would bring a novel therapeutic strategy for lung cancer in the future.

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Conducting Polymer Based Nanobiosensors

Cited by 112 publications

References 70 publications

Nanomaterials towards Biosensing of Alzheimer’s Disease Biomarkers

Nanomaterials towards Biosensing of Alzheimer’s Disease Biomarkers

Electrochemical Aptasensor with Layer‐by‐layer Deposited Polyaniline for Aflatoxin M1 Voltammetric Determination

<p>Biofunctional core-shell polypyrrole–polyethylenimine nanocomplex for a locally sustained photothermal with reactive oxygen species enhanced therapeutic effect against lung cancer</p>

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Conducting Polymer Based Nanobiosensors

Cited by 112 publications

References 70 publications

Nanomaterials towards Biosensing of Alzheimer’s Disease Biomarkers

Nanomaterials towards Biosensing of Alzheimer’s Disease Biomarkers

Electrochemical Aptasensor with Layer‐by‐layer Deposited Polyaniline for Aflatoxin M1 Voltammetric Determination

<p>Biofunctional core-shell polypyrrole&ndash;polyethylenimine nanocomplex for a locally sustained photothermal with reactive oxygen species enhanced therapeutic effect against lung cancer</p>

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<p>Biofunctional core-shell polypyrrole–polyethylenimine nanocomplex for a locally sustained photothermal with reactive oxygen species enhanced therapeutic effect against lung cancer</p>