Conductimetric and potentiometric detection in conventional and microchip capillary electrophoresis

Abstract

Potentiometric detection is rarely used in separation methods but is promising for certain classes of analytes which can only with difficulty be quantified by more standard methods. Conductimetric detection of ions is very versatile and has recently received renewed interest spurned by the introduction of the capacitively coupled contactless configuration. Both are useful and complementary alternatives to the established optical detection methods, and to the more widely known electrochemical method of amperometry. The simplicity of the electrochemical methods makes them particularly attractive for microfabricated devices, but relatively little work has to date been carried out with regard to potentiometric and conductimetric detection.

Potential of Capillary Electrophoresis (CE) and Chip-CE with Dual Detection (Capacitively-Coupled Contactless Conductivity Detection (C4D) and Fluorescence Detection) for Monitoring of Nicotine and Cotinine Derivatization

“…2.5 and 3.0) were investigated. [33][34][35] Further optimization for monitoring of fluorescent product formation was carried out by MEKC-dual detectors (C 4 D and FD). C 4 D could be utilized for determination of EOF marker or non-fluorescent products, which possibly occurred in the reaction mixtures.…”

Bioanalytical profile of the l-arginine/nitric oxide pathway and its evaluation by capillary electrophoresis

“…In addition to the rapid progress of CZE/CCD technology for fused silica capillaries, several on-chip platforms have been proposed (for recent reviews see refs. [294,[308][309][310]323]). In summary, CCD is a very potent and promising technique for both fused silica capillary-and micro-chip-based CZE platforms; however, applications focusing on profiling of L-arginine/NO pathway in biological samples have yet to be developed.…”

A continuous wavelet transform algorithm for peak detection

“…Contactless conductivity detection (CCD), one of the electrochemical techniques, has attracted much attention in recent years (e.g. [9][10][11][12][13][14][15][16][17][18][19][20]). For miniaturized analytical system applications, this type of sensor has the unique advantage of lower chip fabrication costs, easier system integration and reduction of interference of high CE voltage with sensor signals.…”