Abstract:eighteen patients tested reactive with the INSTI TM POCT. Of these 91 stored serum samples were available, 12 of these were false-reactive results (as identified by the initial BIORAD test). When tested with the Determine TM POCT all 12 were non reactive. Of the 79 true reactive INSTI tests, all were reactive when tested with the Determine TM POCT.As a result of this study our clinic policy changed. All patients requesting an instant HIV test are tested using the INSTI TM POCT; all individuals with a reactive … Show more
“…CT images were reconstructed with a filtered back projection algorithm onto a 256 · 256-matrix size. After SPECT acquisition, images were reconstructed using the OSEM algorithm 26 and fused using the General Electric eNTEGRA workstation, software version 1.04 (GE Medical Systems, Waukesha, WI) into a 128 · 128 · 128 matrix size with each voxel representing 3.45 mm 3 . In images showing activity in the bladder or on the perianal or intergluteal skin, the signal was subtracted using in-house software.…”
Section: Spect/ct Imaging Distributionmentioning
confidence: 99%
“…1 Condom use, while prevalent, is inconsistent, and recent data suggest an increase in the incidence of sexually transmitted infections among MSM. [2][3][4][5] Several preexposure prophylaxis (PrEP) strategies are being developed to address rectal HIV acquisition. In iPrEx, daily oral tenofovir/emtricitabine (Truvada) demonstrated modest 42% efficacy in MSM based on a modified intent-to-treat analysis.…”
Rectally applied antiretroviral microbicides for preexposure prophylaxis (PrEP) of HIV infection are currently in development. Since enemas (rectal douches) are commonly used by men who have sex with men prior to receptive anal intercourse, a microbicide enema could enhance PrEP adherence by fitting seamlessly within the usual sexual practices. We assessed the distribution, safety, and acceptability of three enema types-hyperosmolar (Fleet), hypoosmolar (distilled water), and isoosmolar (Normosol-R)-in a crossover design. Nine men received each enema type in random order. Enemas were radiolabeled [ 99m Tc-diethylene triamine pentaacetic acid (DTPA)] to assess enema distribution in the colon using single photon emission computed tomography/ computed tomography (SPECT/CT) imaging. Plasma 99m Tc-DTPA indicated mucosal permeability. Sigmoidoscopic colon tissue biopsies were taken to assess injury as well as tissue penetration of the 99m Tc-DTPA. Acceptability was assessed after each product use and at the end of the study. SPECT/CT imaging showed that the isoosmolar enema had greater proximal colonic distribution (up to the splenic flexure) and greater luminal and colon tissue concentrations of 99m Tc-DTPA when compared to the other enemas ( p < 0.01). Colon biopsies also showed that only the hyperosmolar enema caused sloughing of the colonic epithelium ( p < 0.05). In permeability testing, the hypoosmolar enema had higher plasma 99m Tc-DTPA 24-h area under the concentration-time curve and peak concentration compared to the hyperosmolar and isoosmolar enemas, respectively. Acceptability was generally good with no clear preferences among the three enema types. The isoosmolar enema was superior or similar to the other enemas in all categories and is a good candidate for further development as a rectal microbicide vehicle.
“…CT images were reconstructed with a filtered back projection algorithm onto a 256 · 256-matrix size. After SPECT acquisition, images were reconstructed using the OSEM algorithm 26 and fused using the General Electric eNTEGRA workstation, software version 1.04 (GE Medical Systems, Waukesha, WI) into a 128 · 128 · 128 matrix size with each voxel representing 3.45 mm 3 . In images showing activity in the bladder or on the perianal or intergluteal skin, the signal was subtracted using in-house software.…”
Section: Spect/ct Imaging Distributionmentioning
confidence: 99%
“…1 Condom use, while prevalent, is inconsistent, and recent data suggest an increase in the incidence of sexually transmitted infections among MSM. [2][3][4][5] Several preexposure prophylaxis (PrEP) strategies are being developed to address rectal HIV acquisition. In iPrEx, daily oral tenofovir/emtricitabine (Truvada) demonstrated modest 42% efficacy in MSM based on a modified intent-to-treat analysis.…”
Rectally applied antiretroviral microbicides for preexposure prophylaxis (PrEP) of HIV infection are currently in development. Since enemas (rectal douches) are commonly used by men who have sex with men prior to receptive anal intercourse, a microbicide enema could enhance PrEP adherence by fitting seamlessly within the usual sexual practices. We assessed the distribution, safety, and acceptability of three enema types-hyperosmolar (Fleet), hypoosmolar (distilled water), and isoosmolar (Normosol-R)-in a crossover design. Nine men received each enema type in random order. Enemas were radiolabeled [ 99m Tc-diethylene triamine pentaacetic acid (DTPA)] to assess enema distribution in the colon using single photon emission computed tomography/ computed tomography (SPECT/CT) imaging. Plasma 99m Tc-DTPA indicated mucosal permeability. Sigmoidoscopic colon tissue biopsies were taken to assess injury as well as tissue penetration of the 99m Tc-DTPA. Acceptability was assessed after each product use and at the end of the study. SPECT/CT imaging showed that the isoosmolar enema had greater proximal colonic distribution (up to the splenic flexure) and greater luminal and colon tissue concentrations of 99m Tc-DTPA when compared to the other enemas ( p < 0.01). Colon biopsies also showed that only the hyperosmolar enema caused sloughing of the colonic epithelium ( p < 0.05). In permeability testing, the hypoosmolar enema had higher plasma 99m Tc-DTPA 24-h area under the concentration-time curve and peak concentration compared to the hyperosmolar and isoosmolar enemas, respectively. Acceptability was generally good with no clear preferences among the three enema types. The isoosmolar enema was superior or similar to the other enemas in all categories and is a good candidate for further development as a rectal microbicide vehicle.
“…ex., âge, ethnicité; Griffith, Mitchell, et al, 2012, 2013). Sept études quantitatives sans groupe de comparaison ont aussi été réalisées (Coyne et al, 2009; Garcia, 2013; Goldstein et al, 2011; Hill et al, 2009; Javanbakht et al, 2017; King et Evans, 2020; Rodriguez-Hart et al, 2012). Finalement, cinq études qualitatives ont été réalisées (Dennis, 2007; Griffith, Adams, Hart, & Mitchell, 2012; Griffith, Adams, Hart, Mitchell, Kruger, et al, 2012; Grudzen et al, 2009; Role, 2017).…”
Section: Résultatsunclassified
“…Un total de 13 populations différentes ont été utilisées pour documenter le profil des acteur.trices pornographiques. Au sein de ces 13 populations différentes, six populations ont été recrutées dans une clinique médicale (Coyne et al, 2009; Goldstein et al, 2011; Hill et al, 2009; Javanbakht et al, 2017; King et Evans, 2020; Rodriguez-Hart et al, 2012) et deux populations, dans un organisme communautaire (Griffith, Adams, Hart, & Mitchell, 2012; Griffith, Adams, Hart, Mitchell, Kruger, et al, 2012). Trois populations ont été recrutées par la technique boule de neige (Dennis, 2007; Grudzen et al, 2009; Role, 2017), une population a été recrutée à partir de sites web présentant des films pornographiques ou offrant des emplois dans l’industrie pornographique (Grudzen et al, 2011) et une population d’acteur.trices a été constituée à partir d’observations de scènes de films pornographiques (Garcia, 2013).…”
Cet examen de la portée visait à synthétiser les connaissances sur le profil sociodémographique et psychosexuel des acteur.trices dans les films pornographiques. L’étude a été effectuée selon les lignes directrices PRISMA adaptées pour la rédaction d’un examen de la portée (scoping review). Une recherche de la littérature a été effectuée dans cinq bases de données électroniques et des recherches manuelles ont été effectuées. Les critères étaient les suivants : (1) les données doivent provenir de sources primaires; (2) les participant.es doivent avoir été payé.es pour travailler en tant qu’acteur.trices dans un film pornographique et avoir participé à une activité sexuelle dans ce film; (3) les données doivent inclure des informations sur le profil de ces participant.es. Les études anecdotiques ont été exclues. Au total, 18 études ont rencontré ces critères. Les résultats montrent que la majorité des acteur.trices étaient caucasien.nes et hétérosexuel.les. La majorité avait au moins un diplôme d’études secondaires et un salaire annuel de 25 000 $. Les résultats montrent que ces acteur.trices vivent des difficultés et ont des besoins dans plusieurs sphères de leur vie personnelle et professionnelle (p. ex., antécédents de traumas, risque élevé de contracter des ITSS, problèmes de consommation et de santé mentale), mais qu’ils et elles démontrent certaines forces (p. ex., bonne estime de soi, bonne qualité de vie perçue). L’argent est leur principale motivation à jouer dans des films pornographiques. Ces résultats montrent l’importance de développer des programmes de prévention et d’intervention adaptés à leur réalité et qui répondent à leurs besoins.
“…human immunodeficiency virus (HIV), syphilis, gonorrhoea and chlamydia. Research in USA and UK on AFPs report that sexual intercourse is condomless 80%-90% of the time, [2][3][4][5][6][7] and the prevalence of STI is between 8% and 35%.…”
We report the frequency of sexually transmitted infections (STIs) diagnosed in UK adult film industry performers. A total of 100 adult film performers regularly screened for STIs on an average of every three weeks. High rates of condomless sex were reported and there were STIs recorded during the 19-year period covered by this study (1996 –2015). STIs recorded included gonorrhoea, chlamydia, non-gonococcal urethritis, genital warts, syphilis and Trichomonas vaginalis.
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