The use of mathematical models is widely established in various fields of application. To name but a few of their major applications, mathematical models can improve the controller design of complex technical systems or are able to facilitate the understanding of highly complex biochemical systems. No matter what mathematical models are used for, however, they fail to perform the intended task if they are badly parameterized. In general, during the process of parameterization one tries to make differences between simulation results and measurement data as small as possible. Under the assumption of a suitable model candidate this is done by choosing optimal model parameters. Unfortunately, the majority of used models cannot be solved analytically. For example, many dynamical processes are described by systems of ordinary differential equations (ODEs). Usually, analytical solutions do not exist. Although quite efficient numerical routines are available they usually slow down the parameterization process dramatically. The situation is even more demanding if one has to deal with processes that are described by delay differential equations (DDEs). Commonly, standard DDE solvers show a lack of efficiency as well as of robustness, i.e., they are likely to fail to solve the underlying DDE system. Consequently, it would be of great benefit to eliminate any need of numerical ODE/DDE solvers. Here, the concept of flat inputs comes into play. The key aspect is to transform the DDE system into an algebraic input/output representation, i.e., the inputs of the system are expressed analytically by the outputs and derivatives thereof. Now, the objective of parameterization is to minimize differences between these flat inputs and the physical inputs of the related process. As no numerical DDE solver is involved there is a significant speedup of the parameter identification step. In addition, the presented approach is closely linked to optimal experimental design for parameter identification. In particular, the reformulation of the cost function also affects parameter sensitivities. Using the same measurement data it is possible that previously insensitive model parameters become sensitive. To check this, global parameter sensitivities are determined by Sobol' Indices of first order. All results are demonstrated for the example of a mathematical model of the influenza A virus production.