Conditioning intensity and probability of live birth after blood or marrow transplantation, a BMTSS report

Abstract

We examine the impact of conditioning intensity (low intensity: non-myeloablative/reduced intensity vs. high intensity: myeloablative) and total body irradiation (TBI) on the probability of live birth after blood or marrow transplantation (BMT). Study participants were drawn from the BMT Survivor Study (BMTSS), and included 1,607 survivors transplanted 1974-2014 at age ≤45, with survival ≥2y post-BMT and age at study ≥18. Closest-age, same-sex biologic siblings (n=172) were 1:1 matched with 172 survivors. Survivors and siblings self-reported information on sociodemographic, chronic health conditions, and pregnancies. Within survivor analysis: The association between the primary exposure variable (No TBI/low-intensity conditioning; 200-800cGy TBI/low-intensity conditioning; No TBI/ high-intensity conditioning; >800cGy TBI/ high-intensity conditioning) and the odds of no post-BMT live birth was examined using multivariable logistic regression, adjusting for clinical and demographic variables. Median age at BMT was 31y (IQR=0-45), and median length of follow-up was 14.3y (IQR=2.4-41.4); 39.3% were autologous BMT recipients and 46.6% were female. Overall, 120 (8.7%) survivors reported post-BMT live births. Receipt of >800cGy TBI/ high-intensity conditioning (OR=3.7, 95%CI=1.9-7.0; ref: no TBI/low-intensity conditioning) was associated with higher odds of reporting no live birth post-BMT. In contrast, 200-800cGy TBI/low-intensity conditioning (OR=1.3, 95%CI=0.5-3.3), and no TBI/high-intensity conditioning (OR=0.9, 95%CI=0.5-1.7) were at similar risk of reporting post-BMT live birth as no TBI/low-intensity conditioning. Comparison with biologic siblings: Using conditional logistic regression, we found that BMT survivors were more likely to report no live birth (OR=2.0, 95%CI: 1.2-3.3) compared with siblings. These findings could inform conditioning intensity options for patients wishing to preserve fertility post-BMT.

Women’s Sexual Dysfunctions Following Stem Cell Transplant and the Impact on Couple Relationship

“…The genital tract is commonly negatively impaired due to aggressive chemotherapeutical drugs and TBI. The ovarian tissue is highly sensitive to alkylating agents, widely used in hematological malignancies, and to pelvic irradiation, which causes significant damage [3,17,18]. With non-renewable characteristics and, in the case of continuous and prolonged chemotherapy administration, associated or not with TBI, the destruction of ovarian tissue may be permanent, with no ovarian reserve left intact, determining POF.…”

Successful testicular sperm extraction after hematopoietic stem cell transplantation

“… 1 Improved transplant strategies and therapeutic efficacy have made HSCT a curative option for various indications, mostly comprising malignant blood cell pathologies but also including solid tumors or benign conditions. 2 The conditioning regimen for transplantation often includes alkylating agents and/or total body irradiation (TBI). 2 These treatments usually lead to permanent infertility.…”

“… 2 The conditioning regimen for transplantation often includes alkylating agents and/or total body irradiation (TBI). 2 These treatments usually lead to permanent infertility. 3 In men, the consequences include the impairment and reduction of Sertoli and Leydig cells, leading to the suppression of the spermatogonia pool and increased release of gonadotrophin.…”