Conditioned taste aversion and operant behaviour in rats: Effects of cocaine and a cocaine analogue (Win 35,428)

D'Mello, G.D.; Goldberg, D M; Goldberg, Steven R.; Stolerman, I. P.

doi:10.1016/0028-3908(79)90167-9

Cited by 23 publications

(10 citation statements)

References 5 publications

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“…Spealman et al (1977) reported that doses of cocaine and WIN 35428 in the range of those tested herein could disrupt ongoing schedulecontrolled responding in squirrel monkeys. Similar results were described with cocaine and WIN 35428 in rats responding for food presentation (D'Mello et al, 1981). The in vivo binding data, in fact, suggest that these cocaine analogs have long duration of action at the DAT relative to cocaine, consistent with previous reports (Spealman et al, 1977;Kimmel et al, 2001).…”

Section: Discussionsupporting

confidence: 90%

A Reduced Rate of In Vivo Dopamine Transporter Binding is Associated with Lower Relative Reinforcing Efficacy of Stimulants

Wee

2005

Neuropsychopharmacol

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A slow onset of action has been hypothesized to weaken the reinforcing effects of drugs. The present study evaluated this hypothesis with slow-onset cocaine analogs, WIN 35428, RTI 31, and RTI 51. When cocaine or a cocaine analog was made available to rhesus monkeys (n ¼ 4 or 5) for self-administration under a progressive-ratio (PR) schedule with a 1-h time-out between injections, all the drugs functioned as positive reinforcers. The maximum number of injections was in the order of cocaine4WIN 354284RTI 314RTI 51. In in vivo binding in rat striatum, equipotent doses of cocaine, WIN 35428, RTI 31, and RTI 51 were estimated to displace 25% of [ 3 H]WIN 35428 binding at the dopamine transporters (DAT), respectively, 5.8, 22.4, 30.8, and 44.1 min after the intravenous injection. Further, relative reinforcing efficacy was correlated with rate of DAT binding such that slower displacement of [ 3 H]WIN 35428 was associated with a weaker reinforcing effect. In in vitro binding in monkey brain tissue, the cocaine analogs had higher affinity for monoamine transporter sites, but similar affinity ratios of 5-HTT/DAT, compared to cocaine. Lastly, RTI 31 was shown to function as a positive reinforcer in drug-naïve rhesus monkeys under a fixed-ratio 1 schedule. Collectively, the data support the hypothesis that a slow onset at the DAT is associated with reduced reinforcing efficacy of DAT ligands. The data under both the PR and FR schedules, however, suggest that a slow onset at the DAT influence reinforcing effect only to a limited extent.

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Section: Discussionsupporting

confidence: 90%

A Reduced Rate of In Vivo Dopamine Transporter Binding is Associated with Lower Relative Reinforcing Efficacy of Stimulants

Wee

2005

Neuropsychopharmacol

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“…Reductions in saccharin intakes have been reported using each of these drugs (e.g. Cappell et al 1973;Goudie et al 1978;D'Mello et al 1979;Riley et al 1978). These results would be consistent with the development of CTA, in keeping with a more traditional interpretation of this response based on negative hedonic consequences (Riley and Tuck 1985).…”

Section: Discussionsupporting

confidence: 82%

Conditioning tastant and the acquisition of conditioned taste avoidance to drugs of abuse in DBA/2J mice

Risinger

Boyce

2002

Psychopharmacology

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“…Several studies have examined the effects of stimulants and related drugs on schedule-controlled behavior in mice (Wenger and Dews 1976;Harris et al 1978;McKim 1980;Glowa 1986;Miczek and Haney 1994;Elmer and George 1995). More specifically, cocaine has been shown to suppress operant behavior in mice (Glowa 1986) in a similar pattern to that reported in rats (D'Mello et al 1981;van Haaren and Anderson 1994). The study by Glowa (1986) was conducted in a heterogeneous stock of outbred mice (CD1) and the possibility for differential effects in other strains of mice has not been examined.…”

Section: Introductionmentioning

confidence: 92%

The effects of cocaine on operant responding for food in several strains of mice

et al. 1997

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The availability of numerous genetically homogenous mouse strains permits the analysis of genetic influences on behavior and also behavioral sensitivity (responsivity) to drugs of abuse. The current study was conducted to characterize discriminated operant responding for food in four inbred strains (Balb/cByJ, DBA/2J, C57BL/6J, SJL/J), an F1 Hybrid (C57BL/6xSJL), and one outbred strain (CD1) of mouse. The effect of cocaine on this operant behavior was also examined. Initially, all animals were trained to nosepoke for food on a continuous reinforcement schedule. The minimum response requirement for reinforcement was increased every 5 days until the animals were responding on an FR-15 schedule of reinforcement. All strains increased operant responding as the schedule of reinforcement was raised. However, significant differences in response rate and discrimination learning were observed among the various strains of mice. Cocaine administration reduced operant responding for food in Balb/cByJ, C57BL/6J, C57BL/6xSJL/J and CD1 mice at a dose of 15.0 mg/kg, whereas higher doses were required in DBA/2J mice (30.0 mg/kg) and SJL/J mice (56.0 mg/kg). These results suggest that operant performance and the effect of cocaine on this behavior is differentially influenced by genetic make-up.

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Conditioned taste aversion and operant behaviour in rats: Effects of cocaine and a cocaine analogue (Win 35,428)

Cited by 23 publications

References 5 publications

A Reduced Rate of In Vivo Dopamine Transporter Binding is Associated with Lower Relative Reinforcing Efficacy of Stimulants

A Reduced Rate of In Vivo Dopamine Transporter Binding is Associated with Lower Relative Reinforcing Efficacy of Stimulants

Conditioning tastant and the acquisition of conditioned taste avoidance to drugs of abuse in DBA/2J mice

The effects of cocaine on operant responding for food in several strains of mice

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