Conditioned taste aversion and drugs of abuse: History and interpretation

Verendeev, Andrey; Riley, Anthony L.

doi:10.1016/j.neubiorev.2012.08.004

Cited by 95 publications

(75 citation statements)

References 210 publications

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“…Although several issues remain unresolved (see above), the data in the present study are consistent with the position that drugs of abuse have multiple stimulus effects (positive and negative) that are differentially associated with specific stimulus events that direct approach and avoidance (see Hunt & Amit, 1987;Riley, 2011;Stolerman, 1992). The fact that such drugs are complex stimuli makes them somewhat unique in controlling behavior, and understanding these multiple properties provides insight into the selective behaviors that they condition and how these multiple properties do and do not interact (see also Verendeev & Riley, 2012).…”

Section: Discussionsupporting

confidence: 87%

A history of morphine-induced taste aversion learning fails to affect morphine-induced place preference conditioning in rats

King

Riley

2013

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Drugs of abuse have both rewarding and aversive effects, as indexed by the fact that they support place preferences and taste aversions, respectively. In the present study, we explored whether having a history with the aversive effects of morphine (via taste aversion conditioning) impacted the subsequent rewarding effects of morphine, as measured in the place preference design. In Experiment 1, rats were exposed to a taste aversion procedure in which saccharin was followed by morphine. Place preference conditioning was then initiated in which animals were injected with morphine and placed on one side of a two-chambered apparatus. Animals with a taste aversion history acquired place preferences to the same degree as controls without such a history, suggesting that morphine's affective properties condition multiple effects, dependent on the specific stimuli present during conditioning. To determine whether these results were a reflection of processes operating in traditional associative conditioning, in a modified blocking procedure, place preference conditioning was attempted in the presence of a taste previously associated with morphine (Exp. 2). Under these conditions, animals still acquired morphine-induced place preferences comparable to those of animals without a morphine or conditioning history. These results are consistent with the position that drugs of abuse have multiple stimulus effects (positive and negative) that are differentially associated with specific stimuli (environmental and taste) that drive different behavioral responses (approach and avoidance).

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Section: Discussionsupporting

confidence: 87%

A history of morphine-induced taste aversion learning fails to affect morphine-induced place preference conditioning in rats

King

Riley

2013

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“…En el caso de G1, al agua se le agregó resultados exitosos (Archer y Sjödén, 1979;De la Casa y Lubow, 1995;García, Kimeldorf y Koelling, 1955;Lin, Arthurs, and Reilly, 2014;Verendeev y Riley, 2012); sin embargo, no se ha probado la eficacia del CAS sobre el consumo de endulzantes naturales, como la estevia, la cual es una planta originaria del sudeste de Paraguay, conocida como "hoja dulce", que es natural como la sacarosa, tiene sabor dulce y no aporta calorías a partir de su consumo (Durán, Rodríguez, Cordón y Record, 2012).…”

Section: Solucionesunclassified

“…No obstante, en el caso de la presente investigación, las diferencias registradas en el efecto del CAS sobre el consumo de sacarosa vs. de estevia parecen recaer particularmente en las propiedades organolépti-cas de dichos endulzantes. La mayoría de los estudios previos utilizaron el CAS aplicado a sabores específicos que no contienen consecuencias postingestivas (García y Bach, 1999;Lin, Arthurs y Reilly, 2014;Verendeev y Riley, 2012). En el presente trabajo, aunque la sacarosa y el estevia tienen sabor dulce, la primera contiene calorías, y la segunda no.…”

Section: Procedimientounclassified

Differential effects of conditioned taste aversion on sucrose and stevia intake / Efectos diferenciales del condicionamiento aversivo a sabores sobre la ingesta de sacarosa y estevia

Moreno

López-Espinoza

Gómez

et al. 2018

Rev. Mex. Trast. Alim.

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The association between a food stimulus and a feeling of discomfort produces a food aversion; this procedure is called aversive taste conditioning (ATC). Since there is no clear evidence about the effects of this procedure on the consumption of sweeteners, the purpose of this study was to examine the effectiveness of ATC to decrease the consumption of two natural sweeteners. Thirty Wistar rats were divided into three groups. In phase 1 all groups were exposed to free food access and each group to a different solution: water + sucrose (G1), water + stevia (G2) and unsweetened water (CG). In phase 2 the experimental groups received an intraperitoneal injection of lithium chloride. In phase 3 the groups returned to the conditions of the first phase. After the ATC, the G1 and G2 significantly decreased their beverage consumption, although it was higher than the consumption of CG. The results are discussed in terms of the association between flavor and energy content, which allows establishing new guidelines in the study of the consumption of sweeteners. It is concluded that procedures such as ATC are effective in the control of some disordered eating behaviors.

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“…Only a very sweet solution of saccharin is consumed reliably on first access by an unfasted rat. Hence the volume consumed of a novel saccharin solution was and still is used to measure the conditioning of aversion by association with poisoning or unfamiliar drug effects (Garcia, Kimeldorf & Koelling, 1955;Massei & Cowan, 2002;Verendeev & Riley, 2012). Saccharin has been mixed with sour or bitter agents in order to suppress its intake sufficiently for nutrient-conditioned preferences to be seen (Pain & Booth 1968;Booth & Davis, 1973).…”

Section: Saccharin Preference As the Model Of Appetitementioning

confidence: 99%

Chemesthesis, Thermogenesis, and Nutrition

Hirsch¹

2015

Nutrition and Sensation

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Conditioned taste aversion and drugs of abuse: History and interpretation

Cited by 95 publications

References 210 publications

A history of morphine-induced taste aversion learning fails to affect morphine-induced place preference conditioning in rats

A history of morphine-induced taste aversion learning fails to affect morphine-induced place preference conditioning in rats

Differential effects of conditioned taste aversion on sucrose and stevia intake / Efectos diferenciales del condicionamiento aversivo a sabores sobre la ingesta de sacarosa y estevia

Chemesthesis, Thermogenesis, and Nutrition

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