Conditioned place aversion induced by intragastric administration of ethanol in rats

Fidler, Tara L.; Bakner, Lee; Cunningham, Christopher L.

doi:10.1016/j.pbb.2004.01.010

Cited by 56 publications

(48 citation statements)

References 32 publications

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“…Cannabinoids, as well as other drugs of abuse such as nicotine and cocaine, induce aversion in the CPP paradigm. However, this contrasts with the rewarding properties that can be observed with the use of these drugs in different paradigms (Jorenby et al, 1990;Koob, 1992;Fidler et al, 2004).…”

Section: Discussionmentioning

confidence: 90%

Long-Lasting Increase of Alcohol Relapse by the Cannabinoid Receptor Agonist WIN 55,212-2 during Alcohol Deprivation

López-Moreno

González-Cuevas²,

Fonseca³

et al. 2004

J. Neurosci.

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Section: Discussionmentioning

confidence: 90%

Long-Lasting Increase of Alcohol Relapse by the Cannabinoid Receptor Agonist WIN 55,212-2 during Alcohol Deprivation

López-Moreno

González-Cuevas²,

Fonseca³

et al. 2004

J. Neurosci.

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“…While this review integrates findings across both rats and mice, there may be some intrinsic biological differences in response to the reinforcing and aversive effects of ethanol existing between rats and mice. Ethanol-induced CPP is fairly well established among mouse literature (though notably lacking in the C57BL/6J mouse, the prototypical high-drinking strain; see Table 1), but the condition under which rats will exhibit an ethanol CPP remains unclear (Cunningham and Henderson, 2000;Fidler et al, 2004;Tzschentke, 1998). Fidler et al (2004) discusses the role route of administration plays on the development of CPP.…”

Section: Discussionmentioning

confidence: 99%

“…Ethanol-induced CPP is fairly well established among mouse literature (though notably lacking in the C57BL/6J mouse, the prototypical high-drinking strain; see Table 1), but the condition under which rats will exhibit an ethanol CPP remains unclear (Cunningham and Henderson, 2000;Fidler et al, 2004;Tzschentke, 1998). Fidler et al (2004) discusses the role route of administration plays on the development of CPP. Through the implementation of an intragastric route of administration, they support the conclusion that it does not play a role, in contrast with previous work that suggested that the route of administration did play a role in selected lines of rats (Ciccocioppo et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Ethanol drinking in rodents: is free-choice drinking related to the reinforcing effects of ethanol?

Green¹,

Grahame²

2008

Alcohol

178

167

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Many studies have used voluntary ethanol consumption by animals to assess the influence of genetic and environmental manipulations on ethanol drinking. However, the relationship between home cage ethanol consumption and more formal assessments of ethanol-reinforced behavior using operant and instrumental conditioning procedures is not always clear. The present review attempted to evaluate whether there are consistent correlations between mouse and rat home cage ethanol drinking on the one hand, and either operant oral self-administration (OSA), conditioned taste aversion (CTA) or conditioned place preference (CPP) with ethanol on the other. We also review literature on intravenous ethanol self-administration (IVSA). To collect data, we evaluated a range of genetic manipulations that can change both genes and ethanol drinking behavior including selective breeding, transgenic and knock-out models, and inbred and recombinant inbred strain panels. For a genetic model to be included in the analysis, there had to be published data resulting in differences on home cage drinking and data for at least one of the other behavioral measures. A consistent, positive correlation was observed between ethanol drinking and OSA, suggesting that instrumental behavior is closely genetically related to consummatory and ingestive behavior directed at ethanol. A negative correlation was observed between CTA and drinking, suggesting that ethanol's aversive actions may limit oral consumption of ethanol. A more modest, positive relationship was observed between drinking and CPP, and there were not enough studies available to determine a relationship with IVSA. That some consistent outcomes were observed between widely disparate behavioral procedures and genetic populations may increase confidence in the validity of findings from these assays. These findings may also have important implications when researchers decide which phenotypes to use in measuring alcohol-reward relevant behaviors in novel animal models.

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“…or orally by gavage, and outbred rats showed an aversion for the environment associated with ethanol (Asin et al, 1985;Bormann and Cunningham, 1998;Busse et al, 2005;Fidler et al, 2004;Stewart and Grupp, 1981;Stewart et al, 1996;Van der Kooy et al, 1983). Only in three studies, place conditioning was assessed with voluntary ethanol consumption.…”

Section: Discussionmentioning

confidence: 99%

Alcohol Preference Influences the Subthalamic Nucleus Control on Motivation for Alcohol in Rats

Lardeux

Baunez

2007

Neuropsychopharmacol

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In addition to its role in motor and attentional processes, the subthalamic nucleus (STN) has also been recently demonstrated to be involved in motivational function. Indeed, bilateral STN lesions modulate differentially the motivation for natural rewards and drugs of abuse, increasing motivation for food and decreasing motivation for cocaine in rats. Here, we show that in outbred rats, the STN can modulate the motivation for alcohol according to alcohol preference, without affecting alcohol intake. When performed on 'HighDrinker' rats, STN lesions enhanced the breaking point (BP) under a progressive ratio schedule of reinforcement and increased the time spent in the environment previously paired with alcohol access in the place preference paradigm. In contrast, when performed on 'Low-Drinker' rats, STN lesions decreased the BP and increased the time spent in the environment paired with water. These results show that STN lesions enhance the motivation for alcohol in rats showing a high alcohol preference, whereas they decrease it in rats showing a low preference for alcohol. These results suggest that the STN plays a complex role in the reward circuit, that is not limited to a dissociation between motivation for natural rewards and drugs of abuse, but takes other factors, such as alcohol preference, into account.

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Conditioned place aversion induced by intragastric administration of ethanol in rats

Cited by 56 publications

References 32 publications

Long-Lasting Increase of Alcohol Relapse by the Cannabinoid Receptor Agonist WIN 55,212-2 during Alcohol Deprivation

Long-Lasting Increase of Alcohol Relapse by the Cannabinoid Receptor Agonist WIN 55,212-2 during Alcohol Deprivation

Ethanol drinking in rodents: is free-choice drinking related to the reinforcing effects of ethanol?

Alcohol Preference Influences the Subthalamic Nucleus Control on Motivation for Alcohol in Rats

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