Conditioned pathogenicity of microsporum gypseum biochemical mutants

Weigl, E.

doi:10.1007/bf00704315

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…A genetic approach to the pathogenicity in dermatophytes has been recently introduced with the isolation of three avirulent mutants of M. gypseum (183). Two of the mutants (one auxotroph for histidine and inositol; another one, auxotroph for histidine and lysine) expressed virulence when the aminoacids necessary for growth were injected into the place of inoculation, and when the defense mechanisms of the host were altered by means ofimmunosuppresive drugs.…”

Section: 2-linkagesmentioning

confidence: 99%

The cell wall of fungal human pathogens: Its possible role in host-parasite relationshipsA review

San-Blas

1982

Mycopathologia

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The ability of some fungi to cause disease in animals, and particularly in humans, appears to be related to some peculiar trait of their metabolism not shared by taxonomically related species, so that among thousands of species of fungi, only some 100 are considered pathogenic for humans.Recently, there has been an increase in the basic research aimed at elucidating the physiology, biochemistry, and mechanisms of pathogenicity of the fungi in addition to the responses of the infected host. The results from these studies are often difficult to compare because of the lack of reference cultures, and because variability among laboratories are found for many parameters such as origin of isolates, growth conditions, and fractionation procedures used to obtain chemically defined components of cell walls.This review deals with cell wall structures and their influence in host-parasite relationships in those relatively few pathogenic fungi on which substantial literature exists. Serological properties of the walls are included when available. Readers interested in medical and biological aspects of fungi may consult Rippon's (140) and Emmons et al.'s (51) textbooks, among others. Some reviews on microbial surfaces and their relationships to pathogenicity have been published (160 162)2The pathogenic fungi included in this review are classified according to their cell wall structure, following Bartnicki-Garcia's criteria (15) on the distribution of the two major polysaccharides within the fungal cell wall. This classification is based on the fact that fungi may be subdivided into various categories according to the chemical nature of their walls, and that these categories closely parallel conventional taxonomic boundaries. As seen in Table l, this classification is based on dual combinations of those polysaccharides which appear to be the principal component of vegetative walls, disregarding the presence of small amounts of other classifying polysaccharides. The few pathogenic fungi whose cell walls have been studied to some extent belong to Bartnicki-Garcia's categories 5 (chitin-glucan) and 6 (mannan-glucan) ( Table 2). Besides these main polysaccharides, some minor components of the cell wall may also play important roles in pathogenicity, as antigens, or as virulence factors, and they will be mentioned in this review. DermatophytesDermatophytes are a highly specialized group of fungi that, through long evolutionary processes became adapted to invade, colonize, and nourish themselves on the keratinized tissues of animals. The three genera of dermatophytes are: Trichophyton, Microsporum, and Epidermophyton, of which 21, 15, and 1 species, respectively, are currently considered valid members (1) (ln the Vth Panamerican Conference on Mycoses, April 1980, Caracas, these figures were raised to 27, 16, and 2, respectively). Mating studies have revealed that, for some cases, what were considered as single species of Microsporum and Trichophyton, actually represent complexes of more than one species, indis- Mycopathologia7...

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Section: 2-linkagesmentioning

confidence: 99%

The cell wall of fungal human pathogens: Its possible role in host-parasite relationshipsA review

San-Blas

1982

Mycopathologia

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“…Αντίθετα η μελέτη της μολυσματικότητας Microsporum spp. επί ινδοχοίρων έχει δείξει ότι η έλλειψη μιας γλυκοπρωτείνης από το κυτταρικό τοίχωμα (Ν-ακετυλ-γαλακτοζαμίνης) για τη βιοσύνθεση της οποίας είναι απαραίτητη η θειαμίνη, τα κα θιστά ευαίσθητα στην ανοσολογική απάντηση του ξενιστή (Weigl 1980). Εδώ οφείλεται και η αδυναμία των Microsporum cam's και Microsporum spp.…”

Section: Sabouraud Dextrose Agar-dextrose 10 G/lunclassified

Απομονωση Τυποποιηση Δερματοφυτων. Μελετη Συνθηκων Της Σπορογονιας Των

Μαυρουδεασ¹

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ΜΗ ίΥΓΧεΟΗΤΙ, <ΖΙΗ €ρΑΥΡ.ΑΣΘΑΙ ΚΑΙ ΒΙΟΥ ΚΑΙ τεΧΗΗί ΔΟΞΑ-ZOMÊH2, ΠΑΡΑ ρΑΣΓΉ'' ; Α'ΗΘΡ2ΠΟΙΣ είΣ TOH Αΐεΐ ΧΡΟΗΟΗ' ΠΑΡΑΒΑΙΗΟΗΤΙ Δε"KALeDJOPKΟΥΗΤΙ. ΤΑΗΑΗΤΙΑ ΤΟΥΤε2Η ΚΙΑΣ ΚΑΙ ΑΛΛΗΣ ΔΙΑφΘΟΡΑΣ . ΚΑΙ ΣΑΡΚΙΚ2Ν' ΣΧεΣεδΗ ΜεΤΑ ΓΥΗΑΙΚ2Η Η ΑΝΔΡ2Ν £ΛεΥ©εΡ2Η ΚΑΓΔΟΥΛ2Ν. ') } ! \\ Ί J ί •ί .ΤΑ ΤΗΝ (©εΡ.Α ΚΟΙΗ2ΗΙΑΗ ΜΟΥ ΜεΤΑ Τ2Ν ΑΛΛ2Η, ΑΗΘΡ2Π2Ν

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Keratinolytic and keratinophilic fungi of children's sandpits in the city of Turin

Marchisio

1986

Mycopathologia

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Soils rich in keratinic residues constitute a permanent or occasional reservoir for dermatophytes and keratinolytic and keratinophilic fungi, and are a source of potential infection for man and animals. The keratinolytic and keratinophilic mycoflora of 28 sandpits in Turin was studied to evaluate the risk of fungal skin infections that is run by children as they play in public parks and to lay the ground-work for a next epidemiological study of soil- and animal-inhabiting dermatophytes found in cities, and their impact on human dermatophytoses. Fifty seven species were isolated and a high percentage (52%) showed keratinolytic activity. Species of Microsporum, Trichophyton, Mariannaea, Aphanoascus, Chrysosporium, Malbranchea and Geomyces showed the most active keratinolysis.

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Conditioned pathogenicity of microsporum gypseum biochemical mutants

Cited by 5 publications

References 13 publications

The cell wall of fungal human pathogens: Its possible role in host-parasite relationshipsA review

The cell wall of fungal human pathogens: Its possible role in host-parasite relationshipsA review

Απομονωση Τυποποιηση Δερματοφυτων. Μελετη Συνθηκων Της Σπορογονιας Των

Keratinolytic and keratinophilic fungi of children's sandpits in the city of Turin

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