Conditioned learning in alcohol dependence: implications for cue exposure treatment

Drummond, Colin; Cooper, Troy; Glautier, Steven

doi:10.1111/j.1360-0443.1990.tb01685.x

Cited by 198 publications

(120 citation statements)

References 110 publications

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“…This study found that during craving states elicited by a combination of nicotine deprivation and smoking cue exposure, our craving responses tended to covary and thus provided support for an assumption implicit in many theories of craving, such as conditioned withdrawal, conditioned compensatory response, conditioned appetitive motivation, and social learning theory (Drummond, Cooper, & Glautier, 1994;Niaura et al, 1988). As has been suggested with emotional states such as fear, response covariation is more likely to appear during intense, rather than mild, emotional states (Hodgson & Rachman, 1974;Lang, 1984).…”

Section: Discussionmentioning

confidence: 68%

Effects of nicotine deprivation on craving response covariation in smokers.

Sayette

Martin

Hull

et al. 2003

Journal of Abnormal Psychology

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Most models of craving propose that when cravings are strong, diverse responses--thought to index an underlying craving state--covary. Previous studies provided weak support for this hypothesis. The authors tested whether nicotine deprivation affects degree of covariation across multiple measures related to craving. Heavy and light smokers (N = 127) were exposed to smoking cues while either nicotine deprived or nondeprived. Measures included urge ratings, affective valence, a behavioral choice task assessing perceived reinforcement value of smoking, and smoking-related judgment tasks. Results indicated higher correlations in the nicotine-deprived than in nondeprived group. The measures principally responsible for this effect loaded onto a single common Craving factor for nicotine-deprived but not nondeprived smokers. These findings suggest that, under certain conditions, measures of craving-related processes covary.

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Section: Discussionmentioning

confidence: 68%

Effects of nicotine deprivation on craving response covariation in smokers.

Sayette

Martin

Hull

et al. 2003

Journal of Abnormal Psychology

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“…Many studies have indicated that passive exposure to alcohol-or drug-associated environmental cues may elicit alcohol/drug-seeking behavior in human addicts after weeks or months of abstinence (Drummond et al, 1990;George et al, 2001). In line with clinical data, ethanol is a strong reinforcer for laboratory animals (Samson et al, 2000), and alcohol-associated cues elicit drug-seeking behavior in animals trained to self-administer alcohol, even after protracted abstinence (Shalev et al, 2002;Wedzony et al, 2003;Bienkowski et al, 2004).…”

Section: Introductionmentioning

confidence: 89%

Alcohol Relapse Induced by Discrete Cues Activates Components of AP-1 Transcription Factor and ERK Pathway in the Rat Basolateral and Central Amygdala

Radwańska

Wróbel

Korkosz

et al. 2007

Neuropsychopharmacol

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Alcohol-related cues may induce relapse to heavy alcohol drinking and promote molecular adaptations in discrete brain regions. An exact nature of these molecular alterations is still unknown. In the present study, rats trained to self-administer ethanol were tested for cueinduced reinstatement of ethanol seeking after 30 days of abstinence. Next, a detailed immunocytochemical analysis of c-Fos activation was performed within seven nuclei of the amygdala. In the second experiment, c-Fos activation after reinstatement of ethanol seeking induced by discrete cues was compared with the activation pattern of its putative partner (c-Jun) and regulators (extracellular signalregulated kinases and c-Jun N-terminal kinases). Reexposure to ethanol-associated context cues (an extinction session) potentiated c-Fos expression within the basolateral and central amygdala. Repeated presentation of ethanol-associated discrete cues in an extinction/ reinstatement session led to even stronger c-Fos activation in the latter nuclei. In the second experiment, reexposure to the ethanolassociated context and discrete cues activated both c-Jun and extracellular signal-regulated kinases (ERK1/2) in the basolateral amygdala. Our observations suggest that the basolateral and central amygdala may be specifically involved in alcohol-seeking behavior induced by discrete cues.

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“…Experiential exercises, including cue exposure, were also included in the treatment protocol. Cue exposure has been used in other substance-using populations and typically involves presenting substance-associated stimuli without the opportunity to engage in the substance using behaviors (Childress et al, 1993;Drummond, Cooper, & Glautier, 1990). In our protocol, stimuli that were used to elicit cravings included cigarette packs, lighters, and imaginal exposure exercises.…”

Section: Physical Addictionmentioning

confidence: 99%

Distress Tolerance Treatment for Early-Lapse Smokers

et al. 2008

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A significant percentage of individuals attempting smoking cessation lapse within a matter of days, and very few are able to recover to achieve long-term abstinence. This observation suggests that many smokers may have quit-attempt histories characterized exclusively by early lapses to smoking following quit attempts. Recent negative-reinforcement conceptualizations of early lapse to smoking suggest that individuals' reactions to withdrawal and inability to tolerate the experience of these symptoms, rather than withdrawal severity itself, may represent an important treatment target in the development of new behavioral interventions for this subpopulation of smokers. This article presents the theoretical rationale and describes a novel, multicomponent distress-tolerance treatment for earlylapse smokers that incorporates behavioral and pharmacological elements of standard smokingcessation treatment, whereas drawing distress-tolerance elements from exposure-based and Acceptance and Commitment Therapy-based treatment approaches. Preliminary data from a pilot study (N = 16) are presented, and clinical implications are discussed.

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Conditioned learning in alcohol dependence: implications for cue exposure treatment

Cited by 198 publications

References 110 publications

Effects of nicotine deprivation on craving response covariation in smokers.

Effects of nicotine deprivation on craving response covariation in smokers.

Alcohol Relapse Induced by Discrete Cues Activates Components of AP-1 Transcription Factor and ERK Pathway in the Rat Basolateral and Central Amygdala

Distress Tolerance Treatment for Early-Lapse Smokers

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