Conditioned Flavor Aversions: Assessment of Drug‐Induced Suppression of Food Intake

Riley, Anthony L.; Freeman, Kevin B.

doi:10.1002/0471142301.ns0806es29

Cited by 16 publications

(10 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this context, multiple experiential and subject variables have been shown to impact both the aversive and rewarding effects of drugs of abuse and, thus, may serve as predictive factors in determining propensity for abuse (for reviews, see Cunningham et al , 2006, Doremus-Fitzwater et al , 2010, Riley and Freeman, 2004, Tzschentke, 1998, Verendeev and Riley, 2012). …”

Section: Introductionmentioning

confidence: 99%

Sex differences in 3,4-methylenedioxypyrovalerone (MDPV)-induced taste avoidance and place preferences

King

Wakeford

Taylor

et al. 2015

Pharmacology Biochemistry and Behavior

Self Cite

View full text Add to dashboard Cite

Synthetic cathinones, otherwise known as “bath salts”, have gained significant attention in the last few years as a result of increased use and abuse. One such compound, 3,4-methylenedioxypyrovalerone (MDPV), is pharmacologically and behaviorally similar to cocaine and has been shown to possess both aversive and rewarding effects. For a host of other drugs, each of these effects (and their relative balance) can be influenced by a variety of factors, including sex, which in turn impacts drug taking behavior. In this context, the present assessment sought to determine whether males and females differed in MDPV-induced CTA and CPP. Both male and female Sprague-Dawley rats underwent a combined CTA/CPP procedure, in which an injection of one of three doses of MDPV (1.0, 1.8 or 3.2 mg/kg) was paired with both a novel saccharin solution and a novel environment and changes in preferences for these stimuli were examined. Taste avoidance was evident in both sexes, although this avoidance was weaker in females compared to males. MDPV also produced place preferences in all drug-treated animals, but these preferences did not vary as a function of sex. The fact that females showed a weaker avoidance response compared to males (despite comparable preferences) suggests that females may have a heightened susceptibility to use and abuse of MDPV, paralleling results seen with cocaine and other stimulants. The present findings extend the behavioral characterization of MDPV and the factors that may alter its aversive and rewarding effects.

show abstract

Section: Introductionmentioning

confidence: 99%

Sex differences in 3,4-methylenedioxypyrovalerone (MDPV)-induced taste avoidance and place preferences

King

Wakeford

Taylor

et al. 2015

Pharmacology Biochemistry and Behavior

Self Cite

View full text Add to dashboard Cite

show abstract

“…One method that has proven particularly useful for studying the aversive properties of drugs is the conditioned taste aversion procedure (CTA, [28]). In the traditional form of this Pavlovian conditioning paradigm [29, 30], animals’ are given access to a novel tastant (the conditioned stimulus, or CS), followed by exposure to a drug compound (the unconditioned stimulus, or US). The conditioned response (CR) is reflected as reduced consumption (or avoidance) of the CS when it is presented at a later time.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in the effects of ethanol pre-exposure during adolescence on ethanol-induced conditioned taste aversion in adult rats

Sherrill

Berthold

Koss

et al. 2011

Behavioural Brain Research

View full text Add to dashboard Cite

Alcohol use, which typically begins during adolescence and differs between males and females, is influenced by both the rewarding and aversive properties of the drug. One way adolescent alcohol use may modulate later consumption is by reducing alcohol s aversive properties. Here, we used a conditioned taste aversion (CTA) paradigm to determine if pre-exposure to alcohol (ethanol) during adolescence would attenuate ethanol-induced CTA assessed in adulthood in a sex-dependent manner. Male and female Long-Evans rats were given intraperitoneal (i.p.) injections of saline or 3.0 g/kg ethanol in a binge-like pattern during postnatal days (PD) 35–45. In adulthood (> PD 100), rats were given access to 0.1% saccharin, followed by saline or ethanol (1.0 or 1.5 g/kg, i.p.), over four conditioning sessions. We found sex differences in ethanol-induced CTA, with males developing a more robust aversion earlier in conditioning. Sex differences in the effects of pre-exposure were also evident: males, but not females, showed an attenuated CTA in adulthood following ethanol pre-exposure, which occurred approximately nine weeks earlier. Taken together, these findings indicate that males are more sensitive to the aversive properties of ethanol than females. In addition, the ability of pre-exposure to the ethanol US to attenuate CTA is enhanced in males compared to females.

show abstract

“…In other cases, avoidance of particular types of alcohol has more to do with a physical aversion brought on by the experience of getting sick after imbibing. Taste aversion research has documented this finding scientifically (see Riley & Freeman, 2004a, 2004b, for an overview). Alcohol researchers, over the years, have capitalized on this classical conditioning learning theory to develop therapies that use aversion to help problem drinkers avoid alcohol.…”

Section: Introductionmentioning

confidence: 87%

“Queasy does it”: False alcohol beliefs and memories may lead to diminished alcohol preferences

et al. 2013

View full text Add to dashboard Cite

Studies have shown that false memories can be implanted via innocuous suggestions, and that these memories can play a role in shaping people’s subsequent attitudes and preferences. The current study explored whether participants (N=147) who received a false suggestion that they had become ill drinking a particular type of alcohol would increase their confidence that the event had occurred, and whether their new-found belief would subsequently affect their alcohol preferences. Results indicated that participants who received a suggestion that they had gotten sick drinking rum or vodka before the age of 16 reported increased confidence that the suggested experience had occurred. Moreover, participants who received a false alcohol suggestion also showed a strong trend to report diminished preference for the specified type of alcohol after the false suggestion. Implantation of a false memory related to one’s past drinking experiences may influence current drink preferences and could be an important avenue for further exploration in the development of alcohol interventions.

show abstract

Conditioned Flavor Aversions: Assessment of Drug‐Induced Suppression of Food Intake

Cited by 16 publications

References 76 publications

Sex differences in 3,4-methylenedioxypyrovalerone (MDPV)-induced taste avoidance and place preferences

Sex differences in 3,4-methylenedioxypyrovalerone (MDPV)-induced taste avoidance and place preferences

Sex differences in the effects of ethanol pre-exposure during adolescence on ethanol-induced conditioned taste aversion in adult rats

“Queasy does it”: False alcohol beliefs and memories may lead to diminished alcohol preferences

Contact Info

Product

Resources

About