Conditioned fear response is modulated by a combined action of the hypothalamic–pituitary–adrenal axis and dopamine activity in the basolateral amygdala

Oliveira, Amanda Ribeiro de; Reimer, Adriano E.; Reis, Fernando M. C. V.; Brandão, Marcus Lira

doi:10.1016/j.euroneuro.2012.05.007

Cited by 36 publications

(32 citation statements)

References 56 publications

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“…In contrast, the association between changes in DA transmission and conditioned fear has been previously demonstrated in numerous studies. Thus, recent studies demonstrated that systemic and intra-amygdala injections of sulpiride attenuated the expression of conditioned fear [18]–[20].…”

Section: Introductionmentioning

confidence: 99%

Dopamine D2-Like Receptors Modulate Unconditioned Fear: Role of the Inferior Colliculus

et al. 2014

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BackgroundA reduction of dopamine release or D2 receptor blockade in the terminal fields of the mesolimbic system clearly reduces conditioned fear. Injections of haloperidol, a preferential D2 receptor antagonist, into the inferior colliculus (IC) enhance the processing of unconditioned aversive information. However, a clear characterization of the interplay of D2 receptors in the mediation of unconditioned and conditioned fear is still lacking.MethodsThe present study investigated the effects of intra-IC injections of the D2 receptor-selective antagonist sulpiride on behavior in the elevated plus maze (EPM), auditory-evoked potentials (AEPs) to loud sounds recorded from the IC, fear-potentiated startle (FPS), and conditioned freezing.ResultsIntra-IC injections of sulpiride caused clear proaversive effects in the EPM and enhanced AEPs induced by loud auditory stimuli. Intra-IC sulpiride administration did not affect FPS or conditioned freezing.ConclusionsDopamine D2-like receptors of the inferior colliculus play a role in the modulation of unconditioned aversive information but not in the fear-potentiated startle response.

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Section: Introductionmentioning

confidence: 99%

Dopamine D2-Like Receptors Modulate Unconditioned Fear: Role of the Inferior Colliculus

et al. 2014

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“…Because intra-BNST CGRP infusions increase fos immunoreactivity in the paraventricular nucleus of the hypothalamus (Sink et al 2011)-a nodal point in the HPA axis-and because HPA activity can influence fear learning and expression (Roozendaal 2002;Aerni et al 2004;Donley et al 2005;Schelling et al 2006;Soravia et al 2006;Tronel and Alberini 2007;Taubenfeld et al 2009;Jovanovic et al 2011;Zohar et al 2011;Atsak et al 2012;de Oliveira et al 2013), we also examined the contribution of BNST CGRP receptors to shockinduced corticosterone release.…”

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confidence: 99%

CGRP antagonist infused into the bed nucleus of the stria terminalis impairs the acquisition and expression of context but not discretely cued fear

2013

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Calcitonin gene-related peptide (CGRP) infusions into the bed nucleus of the stria terminalis (BNST) evoke increases in startle amplitude and increases in anxiety-like behavior in the plus maze. Conversely, intra-BNST infusions of the CGRP antagonist CGRP 8 -37 block unconditioned startle increases produced by fox odor. Here we evaluate the contribution of CGRP signaling in the BNST to the development and expression of learned fear. Rats received five pairings of a 3.7-sec light and footshock and were tested for fear-potentiated startle one or more days later. Neither pre-training (Experiment 1) nor pre-test (Experiment 2) infusions of the CGRP antagonist CGRP 8 -37 (800 ng/BNST) disrupted fear-potentiated startle to the 3.7-sec visual cue. However, in both experiments, CGRP 8 -37 infusions disrupted baseline startle increases that occurred when rats were tested in the same context as that in which they previously received footshock (Experiment 3). Intra-BNST CGRP 8 -37 infusions did not disrupt shock-evoked corticosterone release (Experiment 4). These data confirm previous findings implicating BNST CGRP receptors in fear and anxiety. They extend those results by showing an important contribution to learned fear and, specifically, to fear evoked by a shock-associated context rather than a discrete cue. This pattern is consistent with previous models of BNST function that have posited a preferential role in sustained anxiety as opposed to phasic fear responses. More generally, the results add to a growing body of evidence indicating behaviorally, possibly clinically, relevant modulation of BNST function by neuroactive peptides.

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“…A previous study demonstrated that the freezing response was attenuated by removing the adrenal glands in rats 1 h before the test, an effect that was reversed by systemic corticosterone administration . Moreover, metyrapone administration before the test session in nonadrenalectomized rats decreased the duration of conditioned freezing de Oliveira et al 2012). Furthermore, a clinical study reported that metyrapone administration effectively reduced both plasma cortisol concentrations and the strength of an emotional memory in a long-lasting manner, without affecting the retrieval of neutral responses .…”

Section: Discussionmentioning

confidence: 97%

“…Um estudo prévio mostrou que a resposta de congelamento foi atenuada pela remoção das glândulas adrenais de ratos 1 h antes do teste, um efeito revertido pela administração sistêmica de corticosterona . Além disso, a administração de metirapona antes da sessão de teste, em ratos não-adrenalectomizados, também diminuiu o tempo da resposta de congelamento (ROOZENDAALL; BOHUS; DE OLIVEIRA et al, 2012). Ademais, estudos clínicos mostraram que a administração de metirapona foi capaz de reduzir de forma eficiente as concentrações de glicocorticóides plasmáticos e de diminuir a evocação de memórias emocionais de modo duradouro, sem alterar a evocação de respostas de conteúdo neutro .…”

Section: Discussionunclassified

Mediação do medo condicionado contextual por glicocorticóides e mecanismos glutamatérgicos no córtex pré-frontal medial

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Conditioned fear response is modulated by a combined action of the hypothalamic–pituitary–adrenal axis and dopamine activity in the basolateral amygdala

Cited by 36 publications

References 56 publications

Dopamine D2-Like Receptors Modulate Unconditioned Fear: Role of the Inferior Colliculus

Dopamine D2-Like Receptors Modulate Unconditioned Fear: Role of the Inferior Colliculus

CGRP antagonist infused into the bed nucleus of the stria terminalis impairs the acquisition and expression of context but not discretely cued fear

Mediação do medo condicionado contextual por glicocorticóides e mecanismos glutamatérgicos no córtex pré-frontal medial

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