Conditionally immortal neuroepithelial stem cell grafts reverse age-associated memory impairments in rats

Hodges, Helen; Veizovic, T; Bray, Nicholas John; French, S.J.; Rashid, T.; Chadwick, Andrew; Patel, Sara; Gray, Jeffrey A.

doi:10.1016/s0306-4522(00)00408-5

Cited by 43 publications

(31 citation statements)

References 27 publications

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“…Furthermore, there appeared to be an optimal window of time following injury (3-7 days) during which signals were elaborated within the degenerating region and to which NSCs responded with migration and reconstitution of lost neural cells. (Similar observations have been noted by Hodges et al 60 ). Because engrafted donor-derived cells continue to express their LacZ reporter gene, it appeared feasible that desired differentiation, neurite outgrowth, and connectivity of both host and donor-derived cells might be enhanced if donor NSCs were genetically manipulated ex vivo to express certain trophins, cytokines, or other factors.…”

Section: Hypoxic-ischemic Brain Injurysupporting

confidence: 91%

Global gene and cell replacement strategies via stem cells

et al. 2002

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Section: Hypoxic-ischemic Brain Injurysupporting

confidence: 91%

Global gene and cell replacement strategies via stem cells

et al. 2002

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“…99,101 Transplantation of human NSC is associated with cell dispersion into damaged areas of the limbic system, increased hippocampal inhibition, and reduction of spontaneous seizures. Many questions remain to be answered about the ability of SCs to completely differentiate within the host, and to differentiate into region-specific phenotypes rather than glial cells in sclerotic hippocampi, 108 and the long-term integration and survival capacity in the seizure-prone brain of these cells is unknown.…”

Section: Resultsmentioning

confidence: 99%

“…100 Furthermore, differentiation and integration of SC lines into all hippocampal subfields of the aged brain was associated with improvement in spatial learning, which is thought to be hippocampus dependent. 101 These data seem to indicate a potential for using SCs to raise hippocampal inhibition and to restore functional circuitry within seizure damaged areas.…”

Section: Stem/progenitor Cell Transplantsmentioning

confidence: 92%

“…Some investigators have argued that the majority of transplant recipients in clinical settings will in fact be older, intractable patients suffering from neurodegenerative processes 88 and that therefore transplantation studies in aged rats should be explored. 101 A study by Chu et al 55 is notable for reported reduction of recurrent spontaneous seizures, cell dispersion into areas of damage, and enhanced GABAergic inhibition in the damaged hippocampus after transplantation of NSC. In that study, animals experienced 1 hour of continuous seizure induced by LiPC SE.…”

Section: Stem/progenitor Cell Transplantsmentioning

confidence: 99%

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Transplantation of GABA-Producing Cells for Seizure Control in Models of Temporal Lobe Epilepsy

Thompson

2009

Neurotherapeutics

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Summary:A high percentage of patients with temporal lobe epilepsy (TLE) are refractory to conventional pharmacotherapy. The progressive neurodegenerative processes associated with a lifetime of uncontrolled seizures mandate the development of alternative approaches to treat this disease. Transplantation of inhibitory cells has been suggested as a potential therapeutic strategy to achieve seizure suppression in humans with intractable TLE. Preclinical investigations over 20 years have demonstrated that multiple cell types from several sources can produce anticonvulsant, and antiepileptogenic, effects in animal models of TLE. Transplanting GABA-producing cells, in particular, has been shown to reduce seizures in several well-established models. This review addresses experimentation using different sources of transplantable GABAergic cells, highlighting progress with fetal tissue, neural cell lines, and stem cells. Regardless of the source of the GABAergic cells used in seizure studies, common challenges have emerged. Several variables influence the anticonvulsant potential of GABA-producing cells. For example, tissue availability, graft survival, immunogenicity, tumorigenicity, and varying levels of cell migration, differentiation, and integration into functional circuits and the microenvironment provided by sclerotic tissue all contribute to the efficacy of transplanted cells. The challenge of understanding how all of these variables work in concert, in a disease process that has no well-established etiology, suggests that there is still much basic research to be done before rational cell-based therapies can be developed for TLE.

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“…Neurogenesis stimulates learning, social contacts, physical activity, high levels of estrogen, diet, corticosteroids, stress, inflammation and subordinate, inferior position of the individual as an inhibitor. Interestingly, neurogenesis is reduced in depression, and all known anti-depressants, even electroconvulsive therapy, stimulate neurogenesis according to the data obtained in studies [46][47][48][49]. Intraventricular transplantation of human NPC overexpressing choline acetyltransferase sufficiently restored learning and memory ability of AD rats [44].…”

Section: Alzheimer's Diseasementioning

confidence: 96%

Stem cell treatment for age-related neurodegenerative diseases

Nurković¹,

Biševac²,

Mustafić³

et al. 2015

Praxis Med

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SUMMARYThe belief in the inability of neurogenesis, that is the inability to create new neurons after embryonic and early postnatal development of the central nervous system, was rejected in the mid-nineties, when the existence of neurogenesis in restricted areas of CNS adult mammals, including humans, was discovered.Transplantation of stem cells or their derivatives into respective tissues or organs is considered as one of the most promising remedies for many incurable diseases.In this review, we summarized current knowledge and present and future perspectives andchallenges regarding stem cells treatment for Parkinson's and Alzheimer's disease, as the most common age-related neurodegenerative diseases.

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Conditionally immortal neuroepithelial stem cell grafts reverse age-associated memory impairments in rats

Cited by 43 publications

References 27 publications

Global gene and cell replacement strategies via stem cells

Global gene and cell replacement strategies via stem cells

Transplantation of GABA-Producing Cells for Seizure Control in Models of Temporal Lobe Epilepsy

Stem cell treatment for age-related neurodegenerative diseases

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