Conditional survival analysis in Korean patients with gastric cancer undergoing curative gastrectomy

Abstract

BackgroundConditional survival (CS) measures the probability that patients will survive an additional number of years given that they have already survived for a certain period of time.MethodsIn total, 2935 gastric cancer patients who had undergone curative gastrectomy between 1995 and 2011 were enrolled. The Cox proportional hazard regression model was used to evaluate the factors associated with overall survival (OS). Three-year CS estimates at ‘t’ years after surgery were calculated as follows: CS(t) = S(t + 3)/S(t).ResultsThe 1-, 2-, 3-, 4- and 5-year OS rates of the 2935 patients were 96.6 %, 92.0 %, 88.7 %, 85.6 and 82.7 %, respectively. The probability of surviving an additional 3 years on the condition of having already survived 1, 2, 3, 4 and 5 years after surgery were 88.6 %, 89.9 %, 91.0 %, 92.2 % and 93.2 %, respectively. Patients with a higher risk at baseline showed a greater increase in CS over time.ConclusionsCS estimates provide important information about dynamic prognostic changes over time for Korean gastric cancer patients, and as such, can be used to guide long-term follow-up strategies.

Conditional survival of patients with gastric cancer who undergo curative resection: A multi‐institutional analysis in China

“…In our current study, the CDS 3 estimates increased after surgery, and the greatest improvement was observed among patients who initially had unfavorable tumor characteristics. This finding was in accordance with previous studies . For example, patients who had N3b disease had a 44.6% improvement (27.3%‐71.9%) in 5‐year CDS 3 compared with a 6.9% improvement (86.8%‐93.7%) among those who had N0 disease (Fig.…”

“…This finding was in accordance with previous studies. 15,[17][18][19] For example, patients who had N3b disease had a 44.6% improvement (27.3%-71.9%) in 5-year CDS 3 compared with a 6.9% improvement (86.8%-93.7%) among those who had N0 disease (Fig. 3d).…”

“…Conditional survival (CS), which considers the changing hazard rate with increased survival time, provides dynamic risk assessment and more accurate survival information for long‐term prognosis. CS has been applied in the assessment of prognosis for many tumors . Previous studies in Korea, Japan, and the United States evaluated CS in patients with gastric cancer and also provided valuable prognostic information …”

“…15,[17][18][19][20][21][22] Previous studies in Korea, Japan, and the United States evaluated CS in patients with gastric cancer and also provided valuable prognostic information. 15,18,23,24 However, to our knowledge, no previous study has assessed CS among patients with gastric cancer in China. Therefore, the objective of the current study was to estimate the CS of patients with gastric cancer using a large, multi-institutional cohort from China.…”

Characteristics of gastric cancer recurrence five or more years after curative gastrectomy

“…Nonetheless, patients with curative gastrectomy continue to experience recurrence during follow-up. More recent studies have shown that the overall 5-year survival rate of gastric cancer has improved because of curative gastrectomy with chemotherapy (2,3). However, death from gastric cancer is almost entirely caused by recurrent diseases (4).…”