2005
DOI: 10.1016/j.abb.2005.02.022
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Conditional regulation of the human CYP4X1 and CYP4Z1 genes

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Cited by 42 publications
(46 citation statements)
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“…CYP2W1 has been shown to be almost exclusively expressed during embryogenesis and in adult humans it is mainly detected in tumour tissue samples, more frequently from colon and adrenal gland (Karlgren et al, 2005, submitted). With respect to CYP4Z1, it is regulated by the glucocorticoid and progesterone receptors and has been shown to be overexpressed preferentially in breast carcinoma tissue and mammary gland (Rieger et al, 2004;Savas et al, 2005).…”
Section: Oh-docmentioning
confidence: 99%
“…CYP2W1 has been shown to be almost exclusively expressed during embryogenesis and in adult humans it is mainly detected in tumour tissue samples, more frequently from colon and adrenal gland (Karlgren et al, 2005, submitted). With respect to CYP4Z1, it is regulated by the glucocorticoid and progesterone receptors and has been shown to be overexpressed preferentially in breast carcinoma tissue and mammary gland (Rieger et al, 2004;Savas et al, 2005).…”
Section: Oh-docmentioning
confidence: 99%
“…P450 4Z1 mRNA expression is almost undetectable or at a low level in most human tissues, whereas abundant expression is noted in mammary tissue and breast carcinomas. It is still not known which cells express this P450 within breast tissue (Rieger et al, 2004;Savas et al, 2005). Expression has been confirmed in at least two known breast cancer cell lines, T47-D and MCF-7.…”
Section: K Cytochrome P450 4z1mentioning
confidence: 99%
“…Full-length human P450 4X1 cDNA was cloned using human genome and expressed sequence tag databases, and the mRNA was found to be expressed in the trachea and aorta (Savas et al, 2005). The peroxisome proliferator activator receptor ␣ has been reported to be involved in the activation of CYP4X1 gene transcription in a HepG2 cell line (Savas et al, 2005). In human brain, the distribution pattern shows a striking pattern with the highest levels in amygdala (Stark et al, 2008a).…”
Section: J Cytochrome P450 4x1mentioning
confidence: 99%
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