Abstract:The functions of smooth muscle (sm) Na/Ca exchanger (NCX) in the vasculature are controversial and poorly understood. To determine the possible roles of NCX in the vasculature, we developed a novel mouse model (SM‐NCX1 KO) in which the sm‐specific NCX type‐1 (NCX1) was conditionally knocked out using tamoxifen‐inducible Cre‐loxP recombination technique. SM‐NCX1 KO mice exhibit significantly lower blood pressure (BP) and attenuated Ang II‐salt‐induced hypertension (radio telemetry). Isolated, pressurized mesent… Show more
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