Conditional knockout of ITGB4 in bronchial epithelial cells directs bronchopulmonary dysplasia
Yu Chen,
Wang Jiang,
Jin‐Mei Wang
et al.
Abstract:Neonatal respiratory system disease is closely associated with embryonic lung development. Our group found that integrin β4 (ITGB4) is downregulated in the airway epithelium of asthma patients. Asthma is the most common chronic respiratory illness in childhood. Therefore, we suspect whether the deletion of ITGB4 would affect fetal lung development. In this study, we characterized the role of ITGB4 deficiency in bronchopulmonary dysplasia (BPD). ITGB4 was conditionally knocked out in CCSP‐rtTA, Tet‐O‐Cre and IT… Show more
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