Conditional Knock Down Of SOD3 In Smooth Muscle Cells Augments Chronic Hypoxic Pulmonary Vascular Remodeling And Inflammation

Birari, Rahul; Villegas, Leah R.; Locke, Julia; Johnson, R. Daniel; Irwin, David; Majka, Susan M.; Grayck, Eva Nozik

doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4742

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“…Mice carrying an RPE-specific Sod2 knockdown exhibit features of dry AMD including oxidative stress in the RPE and C5 and CD46 deposits in the retina (Seo et al 2012;Mao et al 2014). There are no results describing the effect of Sod3-deficiency on RPE; but a conditional knockdown in smooth muscle cells suggests that it plays an important role in vascular remodeling and inflammation (Birari et al 2012).…”

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confidence: 99%

Interrelation Between Oxidative Stress and Complement Activation in Models of Age-Related Macular Degeneration

Pujol-Lereis

Schäfer

Kuhn

et al. 2015

Advances in Experimental Medicine and Biology

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Millions of individuals older than 50-years suffer from age-related macular degeneration (AMD). Associated with this multifactorial disease are polymorphisms of complement factor genes and a main environmental risk factoroxidative stress. Until now the linkage between these risk factors for AMD has not been fully understood. Recent studies, integrating results on oxidative stress, complement activation, epidemiology and ocular pathology suggested the following sequence in AMD-etiology: initially, chronic oxidative stress results in modification of proteins and lipids in the posterior of the eye; these tissue alterations trigger chronic inflammation, involving the complement system; and finally, invasive immune cells facilitate pathology in the retina. Here, we summarize the results for animal studies which aim to elucidate this molecular interplay of oxidative events and tissue-specific complement activation in the eye.Luciana M. Pujol-Lereis and Nicole Schäfer both have contributed equally to the study.

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confidence: 99%