Condition of Endothelial Functions of Vascular Wall in Hypertensive Patients During Dental Implantation

Abstract

Preoperative correction of periodontal vascular endothelial dysfunction in patients with essential hypertension (HD) can improve the efficiency of dental interventions and reduce the incidence of complications during the implantation process. The periodontal status and functional state of the vascular endothelium were examined in 60 patients with essential hypertension, aged 35 to 45, before and after implantation. The first, main group included 40 people with hypertension, who, in preparation for implantation, along with traditional dental treatment, were prescribed an antioxidant drug Mexidol. Patients of the main group were divided into two subgroups: in subgroup A, a solution of Mexidol was used in the form of applications on the mucous membrane of the gums; in subgroup B, the drug was administered both locally and per os. In the second group, in 20 patients with hypertension, surgical intervention was performed after the traditional complex of therapy. The control group consisted of 10 apparently healthy patients of the same age, with normal blood pressure. Endothelial dysfunction was diagnosed by the level of stable end metabolites of nitric oxide. During the initial examination of patients with hypertension, a significant decrease in the content of nitric oxide metabolites in the blood serum was revealed in comparison with the indicators of patients in the control group. After the course of the therapy, the indicators of nitric oxide in the serum of patients with hypertension increased, more significantly in those who received Mexidol, both locally and orally, which was accompanied by a clear improvement in periodontal status and the absence of complications in the postoperative period.