Condition of Adrenergic Innervation Apparatus of the Thyroid Gland, Blood and Lymph Vessels, and Lymph Nodes during Correction of Hypothyrosis

Абдрешов, С. Н.; Демченко, Г. А.; Mamataeva, A. T.; Atanbaeva, G. K.; Mankibaeva, S. A.; Ахметбаева, Н. А.; Kozhaniyazova, U. N.; Nauryzbai, U. B.

doi:10.1007/s10517-021-05212-5

Cited by 5 publications

(4 citation statements)

References 8 publications

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“…For the development of experimental hypothyroidism, animals received mercazolil at a dose of 20 mg per 100 g of body weight with drinking water for 21 days [8]. To correct thyroid disorders, starting from the 22nd day of the experiment, the animals of the 3rd group received an iodine-containing biologically active additive "Renaissance Plus" balm in powder for 30 days at the rate of 2 μg/100 g of body weight and a decoction of the roots of cinquefoil (Potentilla alba L.) 50 ml per 100 g per day together with drinking water [9,10].…”

Section: Materials and Research Methodsmentioning

confidence: 99%

Morphofunctional State and Microstructure of Regional Lymph Nodes in Experimental Hypothyroidism and Under Correction

Abdreshov,

Kozhaniyazova,

Bgatova

et al. 2023

ArveMED

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Lymph nodes play an important role in the life of humans and animals. In the modern concept, the lymph nodes are the main homeostatic organs of the internal environment of the body, the lymph nodes are part of the lymphatic bed, on the other hand, they are the organs of the lymphoid (immune) system. Purpose: The work presents data on the morphofunctional state and microstructure of regional lymph nodes in experimental hypothyroidism and under correction. Materials and Methods: Experimental hypothyroidism in animals was induced by per os administration of mercazolil at a dose of 20 mg per 100 g of body weight with drinking water for 21 days. To correct thyroid disorders, starting from the 22nd day of the experiment, the animals received for 30 days an iodine-containing dietary supplement "Renaissance Plus" balm in powder at the rate of 2 μg/100 g of body weight and a decoction of the roots of the white cinquefoil (Potentilla alba L.) 50 ml per 100 g per day with drinking water. Results: The results of the study showed that in conditions of hypothyroidism, the lymph node becomes compacted with a decrease in the main structural and functional zones against the background of reduced lymphopoietic function. In the lymphoid nodule, there is a decrease of 1.43 times in the number of lymphoblasts, 1.56 times in the number of medium lymphocytes, 1.50 times in the number of small lymphocytes due to an increase of 1.29 times in the number of macrophages per unit area of the lymphoid nodule in the lymph node. There was a static decrease in the number of small lymphocytes in all structural and functional areas; the number of blasts decreases in the lymphoid nodule and increases in the paracortex and Billroth's strand; the number of macrophages increases in the lymphoid nodule, cerebral sinus, the number of mature plasma cells decreases in the paracortex and Billroth's strand, and there is also inhibition of cellular reactions in the lymph node, which reflects a decrease in the lymphopoietic function of immune activity and as a result of the immunosuppressive action of mercazolil. Conclusions: After an administration of corrigents, the area of the medulla and paracortex was restored to the control level and the ratio of cortical and medulla in the overall structure of the lymph node was leveled.

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Section: Materials and Research Methodsmentioning

confidence: 99%

Morphofunctional State and Microstructure of Regional Lymph Nodes in Experimental Hypothyroidism and Under Correction

Abdreshov,

Kozhaniyazova,

Bgatova

et al. 2023

ArveMED

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“…The lymph nodes experience various protective and adaptive changes, as well as pathogenic changes, because they are the main barrier against the spread of infection from the pathological focus to the bloodstream. Pathogenetic therapy’s ultimate goal of stimulating the body’s natural defenses is achieved by evaluating the lymph nodes’ responses to infectious processes, particularly in light of the growing administration of endolymphatic medication in clinical practice [ 39 , 40 , 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Morphofunctional Alteration of Mesenteric Lymph Nodes in the Inflammation of the Abdominal Cavity

Abdreshov,

Demchenko,

Yeshmukhanbet

et al. 2024

Biology

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This paper provides data regarding the ratios of the functional structures of lymph nodes after inflammation in the abdominal organs. Lymph systems, including lymph nodes, function as filters of tissues and tissue fluids and are places of origin and lymphocyte production for normal physiological functions. They display specific morphological and functional responses in reaction to endogenous and exogenous substances. The morphological pattern of the mesenteric lymph node in experimental rat groups reflects a decrease in its immune function due to the processes of inflammation in the abdominal cavity. These processes work together with the associated organs and their involvement in the abdominal lymph nodes, in which there are discharges of the structure of the paracortical zone under conditions of reduced lymphogenic processes, according to the decrease in the size of the paracortex and the ratios of lymphoid nodes with and without germinal centers. Histological and morphometric analyses show changes in the mesenteric lymph node. These analyses are characterized by changes in the cortical and medullary substances, while the proportion of the cortical structure decreases. We also noted an increase in the number of macrophages in the lymphoid nodes and cerebral sinus, as well as a decrease in the number of mature plasmocytes, the paracortex, and the pulp strands. These changes indicate immunosuppressive effects on the lymph node. Under the conditions of inflammation, the formation of a mixed immune response occurs.

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“…In abdominal inflammation, the lymphatic channel, i.e. the system of lymphatic vessels and lymph nodes, which play an important role in protecting the body from infections and ensuring proper metabolism, may also be affected [4]. Inflammation of the lymphatic channel can lead to its enlargement, soreness and even the formation of purulent foci [5].…”

Section: Introductionmentioning

confidence: 99%

Morphometric changes in the blood and lymphatic channels during inflammation

Abreshov,

Yessenova,

Yeshmukhanbet

et al. 2024

BIO Web Conf.

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When the abdominal cavity is inflamed, the lymphatic channel, i.e. the system of lymph vessels and lymph nodes, which play an important role in protecting the body from infections and ensuring proper metabolism, may be affected. Inflammation of the lymphatic channel can lead to its enlargement, soreness and even the formation of purulent foci. The study of morphometric changes in the lymphatic channel during inflammation is an important task for a more detailed understanding of inflammatory processes occurring in the body. The results of our experiments showed that during inflammatory processes of the abdominal cavity there are changes in the blood and lymphatic vessels. Relative volumes of vessels of different types per unit significantly decreased compared to the indicators of the control group. In submucosa and muscularis the morphometry data confirm the fact of arterial vessels spasm, lymphatic vessel reduction and simultaneous persistent venous vessels expansion. In rats with the developed inflammatory process in lymphatic vessels the expansion of lymphatic slits and significant thickening of the wall of large lymphatic vessels was found, which is associated with an increase in the volume of blood plasma, increasing the load on lymphatic vessels as a drainage system of the body.

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Condition of Adrenergic Innervation Apparatus of the Thyroid Gland, Blood and Lymph Vessels, and Lymph Nodes during Correction of Hypothyrosis

Cited by 5 publications

References 8 publications

Morphofunctional State and Microstructure of Regional Lymph Nodes in Experimental Hypothyroidism and Under Correction

Morphofunctional State and Microstructure of Regional Lymph Nodes in Experimental Hypothyroidism and Under Correction

Morphofunctional Alteration of Mesenteric Lymph Nodes in the Inflammation of the Abdominal Cavity

Morphometric changes in the blood and lymphatic channels during inflammation

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