Condition based divergence in synthesis of tetrahydrobenzo[b]pyrans

Green synthesis of 3-methyl-4-(hetero)aryl methylene isoxazole-5(4H)-ones using WEOFPA/glycerol: evaluation of anticancer and electrochemical behaviour properties

“…A literature survey showed that the synthesis of aryl-3-methylisoxazol-5(4 H )-one derivatives was achieved through the coupling of an aromatic aldehyde with ethyl acetoacetate and hydroxylamine hydrochloride (Scheme 1). This reaction has been performed using different reagents 26 and catalysts in basic media, such as sodium silicate, 27 sodium benzoate, 28 sodium azide, 29 sodium saccharin, 30 sodium citrate, 31 sodium sulfide, 32 sodium ascorbate, 33 sodium tetraborate, 34 tartaric acid, 35 potassium phthalimide, 36 mesolite, 37 DOWEX(R) 50 WX 4 , 38 citric acid, 39 choline chloride/urea, 40 nano-MMT-Sn. 41…”

“…A literature survey showed that the synthesis of aryl-3methylisoxazol-5(4H)-one derivatives was achieved through the coupling of an aromatic aldehyde with ethyl acetoacetate and hydroxylamine hydrochloride (Scheme 1). This reaction has been performed using different reagents 26 and catalysts in basic media, such as sodium silicate, 27 sodium benzoate, 28 sodium azide, 29 sodium saccharin, 30 sodium citrate, 31 sodium sulfide, 32 sodium ascorbate, 33 sodium tetraborate, 34 tartaric acid, 35 potassium phthalimide, 36 mesolite, 37 DOWEX(R) 50 WX 4 , 38 citric acid, 39 choline chloride/urea, 40 nano-MMT-Sn. 41 Even though, the above-mentioned catalytic approaches have their own advantages, most of them suffer from limitations, such as the use of hazardous materials (or solvents), expensive catalysts, environmental problems, production of undesirable waste, long reaction times, harsh reaction conditions and low yield product isolation.…”

Sulfonated Graphene‐Oxide as Metal‐Free Efficient Carbocatalyst for the Synthesis of 3‐Methyl‐4‐(hetero)arylmethylene isoxazole‐5(4H)‐ones and Substituted Pyrazole

“…The convenient methodologies demand solid state heating, solid‐state grinding, ultrasonic irradiation, microwave heating, application of visible light in the presence of sodium acetate in ethanol . Nevertheless, different moisture sensitive reagents are also employed for the synthesis of isoxazole derivatives like phthalimide‐N‐oxyl salts, sodium sulphide, boric acid, sulphated polyborate, sodium azide, potassium sorbate, SnII‐montmorillonite, etc . Most of the conditions, however, suffer from drawbacks such as harsh reaction conditions, high temperature, strongly acidic/basic condition, prolonged reaction time, use of homogeneous catalyst, low yield and suffer from rapid loss of catalytic activity.…”

Novel Pyrano[2,3‐d]thiazole and Thiazolo[4,5‐b]pyridine Derivatives: One‐pot Three‐component Synthesis and Biological Evaluation as Anticancer Agents, c‐Met, and Pim‐1 Kinase Inhibitors

“…Condition‐based divergence builds up a way of directing the reaction to be very rapid and resourceful. Moreover, the goal is to obtain compounds with high biological activity so that we can use them to develop the drug and obtain novel medical features . Such (MCRs) often result in high atom economy and high selectivity products…”

“…Moreover, the goal is to obtain compounds with high biological activity so that we can use them to develop the drug and obtain novel medical features. [2] Such (MCRs) often result in high atom economy and high selectivity products. [3] On the other hand, the two main target synthesized products that have acquired much importance because of their diverse pharmaceutical applications were thiazolo [4,5-b]pyridines derivatives and pyrano [2,3-d]thiazoles derivatives.…”