Conditio Sine Qua Non for de Novo Emergence of New Genes and the Concept of Primordial Building Blocks

Ohno, Susumu; Mori, Nozomu; Matsunaga, Takeshi

doi:10.1007/978-1-4684-5137-5_7

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“…The non-MHC H genes of the central portion of chromosome (Chr) 2 have attracted particular interest because of their associations with and similarities to the MHC (reviewed in Michaelson 1983) and because they include beta 2 microglobulin ([32m) which is considered the prototype of the immunoglobulin family (Ohno et al 1986). The purpose of this communication is to present mapping information on a group of Chr 2 genes whose products are immunologically involved.…”

Section: Introductionmentioning

confidence: 99%

Continued mapping of chromosome 2 genes

et al. 1994

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This report describes our continued efforts to elucidate the genetic fine structure of the central portion of the mouse chromosome (Chr) 2. Mice from our panel of 28 Chr 2 congenic strains were tested: 1) for the presence of the antigens which stimulate Chr 2-reactive lymphocyte clones in mixed lymphocyte reaction (MLR); 2) for the antigens of histocompatibility (H) genes H-42a and H-45a as determined by allograft rejection; and 3) for their ability to respond to the H-Y antigen in a cell-mediated lysis assay. The results obtained in this study have allowed additional mapping of immunologically involved Chr 2 genes. The gene encoding the antigen which stimulates lymphocyte clone 1C11 can be considered wholly different from other Chr2 H genes on the basis of chromosomal recombination. We have assigned the symbol H-48 to this gene. The following gene order has been established: [H-3, B2m, pa], we, [H-42, H-48,] H-45, IR-H-Y, Hd-1, un, H-13, Aw. The order of the bracketed genes is not known. H-44 maps centromeric to IR-H-Y. The genes encoding the antigens that stimulate lymphocyte clones 2G7, 2C10, 1F6, 1B10, and 1H10 map centromeric to H-45.

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Section: Introductionmentioning

confidence: 99%