Condensin Smc4 promotes inflammatory innate immune response by epigenetically enhancing NEMO transcription

Wang, Qinlan; Wang, Chunmei; Li, Nan; Liu, Xingguang; Ren, Wenhui; Wang, Qingqing; Cao, Xuetao

doi:10.1016/j.jaut.2018.05.004

Cited by 27 publications

(23 citation statements)

References 42 publications

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“…A total of ten DEGs were identification as hub genes as follows: SMC4, TOP2A, SMC2, KIF11, KIF23, ANLN, ARHGAP11A, SMC3, SMC6, and RAD50. Verónica Dávalos et al suggested that high levels of structural maintenance of chromosomes 2 (SMC2) may be required to allow WNT-driven cell proliferation which contribute a lot to the development of PAH and that SMC2 down-regulate could lead to tumor cell apoptosis [ 20 , 21 ]. Li et al showed the physiological of peroxisome proliferator-activated receptor γ(PPARγ) and DNA damage response (DDR) by using pulmonary arterial hypertension (PAH) as a model that impaired PPARγ signalling pathway related to endothelial cell dysfunction and disrupted PPARγ-UBR5 (MRE11-RAD50-NBS1) interaction, heightened ATM interactor (ATMIN) expression and DNA lesions.…”

Section: Discussionmentioning

confidence: 99%

Identification of novel biomarkers involved in pulmonary arterial hypertension based on multiple-microarray analysis

Chen

Feng

et al. 2020

Bioscience Reports

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Pulmonary arterial hypertension (PAH) is a life-threatening chronic cardiopulmonary disorder. However, studies providing PAH-related gene expression profiles are scarce. To identify hub genes involved in PAH, we investigate two microarray data sets from gene expression omnibus (GEO). A total of 150 differentially expressed genes (DEGs) were identified by limma package. Enriched Gene Ontology (GO) annotations and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of DEGs mostly included mitotic nuclear division, ATPase activity, and Herpes simplex virus one infection. Ten hub genes from three significant modules were ascertained by Cytoscape (CytoHubba). Gene set enrichment analysis (GSEA) plots showed that transcription elongation factor complex was the most significantly enriched gene set positively correlated with the PAH group. At the same time, solute proton symporter activity was the most significantly enriched gene set positively correlated with the control group. Correlation analysis between hub genes suggested that SMC4, TOP2A, SMC2, KIF11, KIF23, ANLN, ARHGAP11A, SMC3, SMC6 and RAD50 may involve in the pathogenesis of PAH. Then, the miRNA-target genes regulation network was performed to unveil the underlying complex association among them. Finally, RNA extracted from monocrotaline (MCT)-induced Rat-PAH model lung artery tissues were to conduct quantitative real-time PCR (qRT-PCR) to validate these hub genes. In conclusion, our study offers new evidence for the underlying molecular mechanisms of PAH as well as attractive targets for diagnosis and treatment of PAH.

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Section: Discussionmentioning

confidence: 99%

Identification of novel biomarkers involved in pulmonary arterial hypertension based on multiple-microarray analysis

Chen

Feng

et al. 2020

Bioscience Reports

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“…In humans, SMC4 regulates the innate immune response, and in Drosophila , Cap-D3 responds to bacterial infection by up-regulating the expression of antimicrobial peptides (Longworth et al. 2012; Wang et al. 2018).…”

Section: Discussionmentioning

confidence: 99%

Recurrent Losses and Rapid Evolution of the Condensin II Complex in Insects

King

Leonard

Cooper

et al. 2019

Molecular Biology and Evolution

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Condensins play a crucial role in the organization of genetic material by compacting and disentangling chromosomes. Based on studies in a few model organisms, the condensins I and II complexes are considered to have distinct functions, with the condensin II complex playing a role in meiosis and somatic pairing of homologous chromosomes in Drosophila. Intriguingly, the Cap-G2 subunit of condensin II is absent in Drosophila melanogaster, and this loss may be related to the high levels of chromosome pairing seen in flies. Here, we find that all three non-SMC subunits of condensin II (Cap-G2, Cap-D3, and Cap-H2) have been repeatedly and independently lost in taxa representing multiple insect orders, with some taxa lacking all three. We also find that all non-Dipteran insects display near-uniform low-pairing levels regardless of their condensin II complex composition, suggesting that some key aspects of genome organization are robust to condensin II subunit losses. Finally, we observe consistent signatures of positive selection in condensin subunits across flies and mammals. These findings suggest that these ancient complexes are far more evolutionarily labile than previously suspected, and are at the crossroads of several forms of genomic conflicts. Our results raise fundamental questions about the specific functions of the two condensin complexes in taxa that have experienced subunit losses, and open the door to further investigations to elucidate the diversity of molecular mechanisms that underlie genome organization across various life forms.

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“…For example, SMC3 is involved in the transport of germinal centers related to B cells and plays an important role in limiting its malignant transformation ( 40 ). Deletion of SMC4 inhibits the production of pro-inflammatory cytokines such as TNF-α and IL-6 in macrophages ( 41 ). In addition, the SMC5/6 complex has been shown to be involved in a range of immune responses induced by Hepatitis B virus (HBV) infection ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance and Integrative Analysis of the SMC Family in Hepatocellular Carcinoma

et al. 2021

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Worldwide, hepatocellular carcinoma (HCC) is one of the most malignant cancers with poor prognosis. The structural maintenance of chromosomes (SMC) gene family has been shown to play important roles in human cancers. Nevertheless, the role of SMC members in HCC is not well-understood. In this study, we comprehensively explored the role of the SMC family in HCC using a series of bioinformatic analysis tools. Studies have demonstrated that the mRNA expression levels of SMC1A, SMC1B, SMC2, SMC4, and SMC6 are significantly overexpressed in HCC, and the protein levels of SMC1A, SMC2, SMC3, SMC4, SMC5, and SMC6 are similarly elevated. Moreover, HCC patients with high SMC2 and SMC4 expression levels exhibit poor survival. Using KEGG and GO analyses, we analyzed the enrichment of gene expression in the biological functions and pathways of the SMC family in HCC. Immune infiltration analysis revealed that the expression of the SMC family is closely associated with B cells, CD4+ T cells, CD8+ T cells, macrophages, neutrophils, and DCs. In conclusion, our findings will enhance a more thorough understanding of the SMC family in HCC progression and provide new directions for the diagnosis and treatment of HCC in the future.

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Condensin Smc4 promotes inflammatory innate immune response by epigenetically enhancing NEMO transcription

Cited by 27 publications

References 42 publications

Identification of novel biomarkers involved in pulmonary arterial hypertension based on multiple-microarray analysis

Identification of novel biomarkers involved in pulmonary arterial hypertension based on multiple-microarray analysis

Recurrent Losses and Rapid Evolution of the Condensin II Complex in Insects

Clinical Significance and Integrative Analysis of the SMC Family in Hepatocellular Carcinoma

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