Condensed Pyridines; 1. A Convenient Method for Synthesis of Novel 3-Cyanopyridine-2(1H)-selenones and 3-Aminoselenolo [2,3-b]pyridines

Selenium-containing heterocycles: Part 2. Reactions of 3-amino-4,6-dimethyl-selenolo[2,3-b]pyridine-2-carbonitrile and related fused tetracyclic systems

“…8 Heating of compound 11 with equimolar amounts of cyanoacetic acid or benzoic acid hydrazide furnished the 2-(substituted alkyl/phenyl)-7,9-dimethylpyrido [3', temperature 210°C) were recorded on a JEOL JMS600 instrument. 1 H NMR spectra were obtained on a Varian spectrometer (90 MHz) using tetramethylsilane as internal reference. 13 C NMR spectra were recorded on a Mercury-300BB NMR300 at Cairo University.…”

“…A literature survey indicates that only few publications are concerned with the incorporation of a selenium atom in the pyridine ring. [1][2][3][4][5] Consequently, the synthesis of new classes of heterocyclic systems containing the selenolopyridine moiety may be considered to be a virgin research area. Moreover, previous work in our laboratory describes the synthesis of pyrimidoselenolo [2,3-b]quinoline 6 and pyrimidoselenolo [2,3-c]pyridazine derivatives, 7 which indicate that certain compounds bearing the selenophene goal of chemical research.…”

“…Moreover, previous work in our laboratory describes the synthesis of pyrimidoselenolo [2,3-b]quinoline 6 and pyrimidoselenolo [2,3-c]pyridazine derivatives, 7 which indicate that certain compounds bearing the selenophene goal of chemical research. In Part 1 8 we published the synthesis of selenolo [2,3-b]pyridine, pyrido [3',2':4,5]selenolo [3,2-d]pyrimidine, 7,8-dihydro-2,4-dimethylpyrrolo[1,2-a] pyrido [3',2':4,5]selenolo [3,2-d]pyrimidin-10(6H)-one and 7,9-dimethylpyrido [3',2':4,5]selenolo [3,2-d] [1,2,4]triazolo [4,3-c]pyrimidine derivatives. The aforementioned properties of selenium organic compounds prompted further efforts in continuation of our work [6][7][8][9][10] on the quest for novel heterocyclic systems containing selenium exhibiting biological activity, and we report herein new classes of fused selenium-containing derivatives containing the selenolo [2,3-b]pyridine system.…”

Synthesis of 7-acetyl-8-aryl(hetaryl)- 6-hydroxy-1,6-dimethyl-3-selenoxo-2,3,5,6,7,8-hexahydroiso-quinoline-4-carbonitriles by the condensation of 2,4-diacetyl-3-aryl(hetaryl)- 5-hydroxy-5-methyl-cyclohexanones with cyanoselenoacetamide

“…Cyanoselenoacetamide (2) was obtained by the procedure of [6]. 7-Acetyl-6-hydroxy-1,6-dimethyl-8-(pyrid-3-yl)-3-selenoxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile (3a).…”

Simple synthesis of selenium-containing 1,2-dihydro-2-oxonicotinates

“…Purity of the obtained compounds was monitored by TLC on Silufol UV-254 plates, eluting with acetone-hexane (1:1) and using iodine vapor and UV visualization. The cyanoselenoacetamide (1) was prepared by a known method [13]. All of the syntheses were carried out under an argon atmosphere.…”