Condensation von Malonsäure mit aromatischen Aldehyden durch Ammoniak und Amine

Abstract

1)Ich hake es fiir wahrscheinlich, dass die hier beobachteten Reactionen zwischen Benzylideneminen (vielleicht auch allgemeiner: Alkylidenaminen) ond Malonstlure in naher Beziehung stehen zu den Additionsreactionen, welche diese Amine nach Untersuchuogen von R. S c h i f f und C. B e r t i n i (diese Berichte 30, 501 u. 31, 205) rnit dem Ester der Malonsiiure geben.

Synthesis and Molecular Structures of (E)-non-2-enoic Acid and (E)-dec-2-enoic Acid

“…However, until now there has been no X-ray determination of the crystal structure of C9 or its homologue C10. The syntheses of the two unsaturated α,β-carboxylic acids C9 and C10 are conducted by a convenient adapted condensation reaction of malonic acid and the appropriate aldehydes at room temperature in high yields and purities as depicted in Scheme 1 [27][28][29][30]. Scheme 1.…”

Multi-Bond Forming Processes in Efficient Synthesis

“…[108] The use of cycloadditions in MCRs is a particularly effective way of generating complexity in a rapid and convergent manner. [109,110] The Knoevenagel condensation, [111] which generates a hetero-or carbo-diene, has been used to generate reactive intermediates that undergo cycloaddition. [112] Nandaluru and Bodwell have recently used such an approach in the synthesis of cannabinol (Scheme 15).…”

Microwave-Assisted Syntheses in Organic Chemistry

“…The Knoevenagel reaction [32] is a modified aldol condensation between an aldehyde or ketone, and an active methylene group containing compound in the presence of a base catalyst. The reaction is usually followed by a spontaneous dehydration step resulting in an unsaturated product.…”